ENSMUSG00000028970


Mus musculus

Features
Gene ID: ENSMUSG00000028970
  
Biological name :Abcb1b
  
Synonyms : Abcb1b / ATP-binding cassette, sub-family B (MDR/TAP), member 1B / P06795
  
Possible biological names infered from orthology : ABCB1 / ATP binding cassette subfamily B member 1 / P08183
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 8798147
Gene end: 8866315
  
Corresponding Affymetrix probe sets: 10519555 (MoGene1.0st)   1418872_at (Mouse Genome 430 2.0 Array)   1446701_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000009058
Ensembl peptide - ENSMUSP00000143766
Ensembl peptide - ENSMUSP00000143612
Ensembl peptide - ENSMUSP00000143023
NCBI entrez gene - 18669     See in Manteia.
MGI - MGI:97568
RefSeq - NM_011075
RefSeq Peptide - NP_035205
swissprot - A0A0G2JGL4
swissprot - A0A0G2JF49
swissprot - B2RUR3
swissprot - P06795
Ensembl - ENSMUSG00000028970
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcb4ENSDARG00000010936Danio rerio
 ABCB1ENSGALG00000008912Gallus gallus
 ABCB1ENSG00000085563Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcb1a / P21447 / Multidrug resistance protein 1A / ABCB1* / P08183* / ATP binding cassette subfamily B member 1*ENSMUSG0000004058484
Abcb4 / P21440 / Phosphatidylcholine translocator ABCB4 / P21439* / ATP binding cassette subfamily B member 4*ENSMUSG0000004247670
Abcb5 / B5X0E4 / ATP-binding cassette, sub-family B (MDR/TAP), member 5 / Q2M3G0* / ATP binding cassette subfamily B member 5*ENSMUSG0000007279151
Abcb11 / Q9QY30 / ATP-binding cassette, sub-family B (MDR/TAP), member 11 / O95342* / ATP binding cassette subfamily B member 11*ENSMUSG0000002704848


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0042908 xenobiotic transport IEA
 biological_processGO:0055085 transmembrane transport IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0046581 intercellular canaliculus IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008559 xenobiotic transmembrane transporting ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor,Tg(Thy1-AppDutch)#Jckr/0
Genetic Background: FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-AppDutch)#Jckr

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0008351 decreased gamma-delta intraepithelial T cell number "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pax6tm1Pgr/Pax6+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor
Genetic Background: FVBTac.129P2-Abcb1btm1Bor Abcb1atm1Bor

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor,Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: FVB.129P2-Abcb1btm1Bor Abcb1atm1Bor Abcc2tm1Ahs

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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