ENSG00000085563


Homo sapiens

Features
Gene ID: ENSG00000085563
  
Biological name :ABCB1
  
Synonyms : ABCB1 / ATP binding cassette subfamily B member 1 / P08183
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q21.12
Gene start: 87503633
Gene end: 87713323
  
Corresponding Affymetrix probe sets: 209993_at (Human Genome U133 Plus 2.0 Array)   209994_s_at (Human Genome U133 Plus 2.0 Array)   243951_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444095
Ensembl peptide - ENSP00000478255
Ensembl peptide - ENSP00000265724
Ensembl peptide - ENSP00000399419
NCBI entrez gene - 5243     See in Manteia.
OMIM - 171050
RefSeq - NM_000927
RefSeq - NM_001348944
RefSeq - NM_001348945
RefSeq - NM_001348946
RefSeq Peptide - NP_001335873
RefSeq Peptide - NP_000918
RefSeq Peptide - NP_001335875
RefSeq Peptide - NP_001335874
swissprot - P08183
swissprot - E7EWT8
swissprot - A4D1D2
Ensembl - ENSG00000085563
  
Related genetic diseases (OMIM): 120080 - {Colchicine resistance}, 120080
  612244 - {Inflammatory bowel disease 13}, 612244
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcb4ENSDARG00000010936Danio rerio
 ABCB1ENSGALG00000008912Gallus gallus
 Abcb1aENSMUSG00000040584Mus musculus
 Abcb1bENSMUSG00000028970Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABCB4 / P21439 / ATP binding cassette subfamily B member 4ENSG0000000547176
ABCB5 / Q2M3G0 / ATP binding cassette subfamily B member 5ENSG0000000484654
ABCB11 / O95342 / ATP binding cassette subfamily B member 11ENSG0000007373451


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR030258  Multidrug resistance protein 1
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle IDA
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0042493 response to drug TAS
 biological_processGO:0042908 xenobiotic transport IEA
 biological_processGO:0045332 phospholipid translocation IDA
 biological_processGO:0047484 regulation of response to osmotic stress IMP
 biological_processGO:0055085 transmembrane transport TAS
 biological_processGO:0072089 stem cell proliferation IMP
 biological_processGO:0099040 ceramide translocation IDA
 biological_processGO:1901529 positive regulation of anion channel activity IMP
 biological_processGO:2001225 regulation of chloride transport IMP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane TAS
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005215 transporter activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding TAS
 molecular_functionGO:0008559 xenobiotic transmembrane transporting ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances TAS
 molecular_functionGO:0090554 phosphatidylcholine-translocating ATPase activity IDA
 molecular_functionGO:0090555 phosphatidylethanolamine-translocating ATPase activity IDA
 molecular_functionGO:0099038 ceramide-translocating ATPase activity IDA


Pathways (from Reactome)
Pathway description
Abacavir transmembrane transport
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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