ENSMUSG00000040584


Mus musculus

Features
Gene ID: ENSMUSG00000040584
  
Biological name :Abcb1a
  
Synonyms : Abcb1a / Multidrug resistance protein 1A / P21447
  
Possible biological names infered from orthology : ABCB1 / ATP binding cassette subfamily B member 1 / P08183
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: A1
Gene start: 8660077
Gene end: 8748575
  
Corresponding Affymetrix probe sets: 10519527 (MoGene1.0st)   1419758_at (Mouse Genome 430 2.0 Array)   1419759_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000041204
NCBI entrez gene - 18671     See in Manteia.
MGI - MGI:97570
RefSeq - XM_006503556
RefSeq - NM_011076
RefSeq - XM_006503555
RefSeq Peptide - NP_035206
swissprot - P21447
Ensembl - ENSMUSG00000040584
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abcb4ENSDARG00000010936Danio rerio
 ABCB1ENSGALG00000008912Gallus gallus
 ABCB1ENSG00000085563Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abcb1b / P06795 / ATP-binding cassette, sub-family B (MDR/TAP), member 1B / ABCB1* / P08183* / ATP binding cassette subfamily B member 1*ENSMUSG0000002897084
Abcb4 / P21440 / Phosphatidylcholine translocator ABCB4 / P21439* / ATP binding cassette subfamily B member 4*ENSMUSG0000004247674
Abcb5 / B5X0E4 / ATP-binding cassette, sub-family B (MDR/TAP), member 5 / Q2M3G0* / ATP binding cassette subfamily B member 5*ENSMUSG0000007279151
Abcb11 / Q9QY30 / ATP-binding cassette, sub-family B (MDR/TAP), member 11 / O95342* / ATP binding cassette subfamily B member 11*ENSMUSG0000002704849


Protein motifs (from Interpro)
Interpro ID Name
 IPR003439  ABC transporter-like
 IPR003593  AAA+ ATPase domain
 IPR011527  ABC transporter type 1, transmembrane domain
 IPR017871  ABC transporter, conserved site
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036640  ABC transporter type 1, transmembrane domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000086 G2/M transition of mitotic cell cycle ISO
 biological_processGO:0006855 drug transmembrane transport IEA
 biological_processGO:0015893 drug transport IDA
 biological_processGO:0042908 xenobiotic transport IEA
 biological_processGO:0045332 phospholipid translocation IDA
 biological_processGO:0047484 regulation of response to osmotic stress ISO
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0072089 stem cell proliferation ISO
 biological_processGO:0099040 ceramide translocation IDA
 biological_processGO:1901529 positive regulation of anion channel activity ISO
 biological_processGO:2001225 regulation of chloride transport ISO
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IDA
 cellular_componentGO:0046581 intercellular canaliculus IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008559 xenobiotic transmembrane transporting ATPase activity EXP
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0042623 ATPase activity, coupled IDA
 molecular_functionGO:0042626 ATPase activity, coupled to transmembrane movement of substances IEA
 molecular_functionGO:0090554 phosphatidylcholine-translocating ATPase activity IDA
 molecular_functionGO:0090555 phosphatidylethanolamine-translocating ATPase activity IDA
 molecular_functionGO:0099038 ceramide-translocating ATPase activity IDA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000488 abnormal intestinal epithelium morphology "anomalous structure or development of the cellular avascular layer of the digestive tube passing from the stomach to the anus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000491 crypt abscesses "an exudate collection associated with inflammation in the crypts of Lieberkuhn of the intestinal mucosa; often associated with ulcerative colitis" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000511 abnormal intestinal mucosa morphology "structural or developmental anomalies of the mucous lining of the intestine; this consists of epithelium, lamina, propria, and a layer of smooth muscle cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000512 intestinal ulcer "lesions in the mucous lining of the intestine" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

 MP:0000811 hippocampal neuron degeneration "a retrogressive impairment of function or destruction of the neuronal cells in the hippocampus" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:72427]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

 MP:0001386 abnormal maternal nurturing "failure of mothers to tend offspring" [J:39801]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Npc1m1N/Npc1m1N
Genetic Background: involves: 129/Ola * BALB/c

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Npc1m1N/Npc1m1N
Genetic Background: involves: 129/Ola * BALB/c

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0002461 increased circulating immunoglobulin concentration "greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002497 increased IgE "greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002816 colitis "local accumulation of fluid, plasma proteins, and leukocytes in the colon region of the large intestine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0002822 catalepsy "a condition characterized by inactivity, lack of response to stimuli, and a tendency to maintain an immobile posture; the limbs tend to remain in whatever position they are placed (waxy rigidity); occurs with some psychoses, nervous system drug toxicity, and other conditions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

 MP:0003304 large intestinal inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the large intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0003329 amyloid beta deposits 
Show

Allelic Composition: Tet2tm1.1Mjxu/Tet2+
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor,Tg(Thy1-AppDutch)#Jckr/0
Genetic Background: FVB.Cg-Abcb1btm1Bor Abcb1atm1Bor Tg(Thy1-AppDutch)#Jckr

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0004611 increased susceptibility to ototoxicity-induced hearing loss "greater than normal reduction in hearing sensitivity following exposure to an ototoxic compound, such as aminoglycoside-induced hearing loss mediated via a glutamate excitotoxic process" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor
Genetic Background: FVBTac.129P2-Abcb1btm1Bor Abcb1atm1Bor

 MP:0004842 abnormal large intestine crypts of Lieberkuhn morphology "any structural anomaly in the tubular intestinal glands found in the mucosal membranes of the large intestine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0004999 abnormal blood-inner ear barrier function "anomaly in the function of the group of barriers and transport systems which regulate the transport of various substances from blood to inner ear tissue and maintain the microhomeostasis and functional integrity of the inner ear; the endothelial cells of the inner ear blood capillaries, linked to each other by tight junctions, represent the main component of the blood-inner ear barrier" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor
Genetic Background: FVBTac.129P2-Abcb1btm1Bor Abcb1atm1Bor

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

 MP:0005037 mucous diarrhea "presence of considerable mucous in the stools" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71506]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0005167 abnormal blood-brain barrier "anomaly in the structure or function of the group of barriers and transport systems in the brain capillary endothelium that controls the entrance of substances into the brain extracellular space from the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

 MP:0008267 abnormal hippocampus CA3 region morphology 
Show

Allelic Composition: Wfs1tm1Yoka/Wfs1tm1Yoka
Genetic Background: B6.Cg-Wfs1tm1Yoka

 MP:0008351 decreased gamma-delta intraepithelial T cell number "reduced number of a gamma-delta T cell present in columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [CL:0000801, ISBN:0781735149]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0008401 abnormal CD8 positive, alpha-beta intraepithelial T cell morphology "any structural anomaly of a CD8-positive, alpha-beta T cell of the columnar epithelia such as in the gastrointestinal tract; intraepithelial T cells often have distinct developmental pathways and activation requirements" [ISBN:0781735149]
Show

Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008501 increased IgG2b level "greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Wt1tm2Hst/Wt1+
Genetic Background: chimera involves: 129P2/OlaHsd * C57BL/6JLac * CBA/CaLac

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Abcb1amds/Abcb1amds
Genetic Background: involves: CF-1

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

 MP:0008875 abnormal pharmacokinetics of xenobiotics "any anomaly in the absorbtion, distribution, metabolism or elimination of a foreign compound" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor
Genetic Background: FVBTac.129P2-Abcb1btm1Bor Abcb1atm1Bor

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor
Genetic Background: FVBTac.129P2-Abcb1atm1Bor

Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Abcb1btm1Bor/Abcb1btm1Bor,Abcc2tm1Ahs/Abcc2tm1Ahs
Genetic Background: FVB.129P2-Abcb1btm1Bor Abcb1atm1Bor Abcc2tm1Ahs

 MP:0010027 increased liver cholesterol level "greater than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Abcb1atm1Bor/Abcb1atm1Bor,Npc1m1N/Npc1m1N
Genetic Background: involves: 129/Ola * BALB/c

 MP:0013803 increased IgG2 level "greater than normal immunoglobulin class G2 level" [MGI:Annie_Speak]
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Allelic Composition: Tbptm1.1Xjl/Tbp+
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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