ENSMUSG00000027613


Mus musculus

Features
Gene ID: ENSMUSG00000027613
  
Biological name :Eif6
  
Synonyms : Eif6 / Eukaryotic translation initiation factor 6 / O55135
  
Possible biological names infered from orthology : AL121753.1 / P56537
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 155819832
Gene end: 155826925
  
Corresponding Affymetrix probe sets: 10488929 (MoGene1.0st)   1427578_a_at (Mouse Genome 430 2.0 Array)   1431582_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029142
Ensembl peptide - ENSMUSP00000123190
Ensembl peptide - ENSMUSP00000120206
Ensembl peptide - ENSMUSP00000115715
Ensembl peptide - ENSMUSP00000105266
NCBI entrez gene - 16418     See in Manteia.
MGI - MGI:1196288
RefSeq - NM_010579
RefSeq Peptide - NP_034709
swissprot - A6PWZ2
swissprot - O55135
swissprot - D6RJJ3
swissprot - Q545K4
swissprot - D6RG53
swissprot - B1AZQ4
Ensembl - ENSMUSG00000027613
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif6ENSDARG00000020232Danio rerio
 EIF6ENSGALG00000033993Gallus gallus
 AL121753.1ENSG00000261582Homo sapiens
 EIF6ENSG00000242372Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002769  Translation initiation factor IF6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000054 ribosomal subunit export from nucleus IEA
 biological_processGO:0000460 maturation of 5.8S rRNA IBA
 biological_processGO:0000470 maturation of LSU-rRNA IBA
 biological_processGO:0006110 regulation of glycolytic process IMP
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation IEA
 biological_processGO:0032868 response to insulin IMP
 biological_processGO:0035195 gene silencing by miRNA ISO
 biological_processGO:0035278 miRNA mediated inhibition of translation ISO
 biological_processGO:0042254 ribosome biogenesis IEA
 biological_processGO:0042256 mature ribosome assembly IEA
 biological_processGO:0042273 ribosomal large subunit biogenesis IEA
 biological_processGO:0042304 regulation of fatty acid biosynthetic process IMP
 biological_processGO:0045652 regulation of megakaryocyte differentiation IMP
 biological_processGO:0045727 positive regulation of translation IMP
 biological_processGO:1902626 assembly of large subunit precursor of preribosome IBA
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005638 lamin filament IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005730 nucleolus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005882 intermediate filament IDA
 cellular_componentGO:0030687 preribosome, large subunit precursor IBA
 molecular_functionGO:0003743 translation initiation factor activity IEA
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0043023 ribosomal large subunit binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0003402 decreased liver weight "reduced average weight of the bile-secreting exocrine gland" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0004046 abnormal mitosis "anomaly in the process of cell division including both division of the nucleus (karyokinesis) and the cytoplasm (cytokinesis) " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0009115 abnormal fat cell morphology "any structural anomaly of a fat-storing cell found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

 MP:0011094 complete embryonic lethality before implantation "death of all organisms of a given genotype in a population between fertilization and implantation (Mus: E0 to less than E4.5)" [MGI:csmith]
Show

Allelic Composition: Pde6brd1/Pde6brgsc1754
Genetic Background: involves: C3H * C57BL/6JJcl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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