ENSMUSG00000027671


Mus musculus

Features
Gene ID: ENSMUSG00000027671
  
Biological name :Actl6a
  
Synonyms : actin-like 6A / Actl6a / Q9Z2N8
  
Possible biological names infered from orthology : O96019
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: A3
Gene start: 32706298
Gene end: 32726973
  
Corresponding Affymetrix probe sets: 10491385 (MoGene1.0st)   1416569_at (Mouse Genome 430 2.0 Array)   1429883_at (Mouse Genome 430 2.0 Array)   1456730_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029214
Ensembl peptide - ENSMUSP00000141657
Ensembl peptide - ENSMUSP00000141543
Ensembl peptide - ENSMUSP00000141354
Ensembl peptide - ENSMUSP00000114317
NCBI entrez gene - 56456     See in Manteia.
MGI - MGI:1861453
RefSeq - XM_006535503
RefSeq - NM_019673
RefSeq Peptide - NP_062647
swissprot - A0A0A6YWR1
swissprot - D3YVN1
swissprot - A0A0A6YW15
swissprot - Q505L1
swissprot - Q9Z2N8
swissprot - A0A0A6YWG8
Ensembl - ENSMUSG00000027671
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 actl6aENSDARG00000070828Danio rerio
 ACTL6AENSGALG00000009061Gallus gallus
 ACTL6AENSG00000136518Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Actl6b / Q99MR0 / actin-like 6B / O94805*ENSMUSG0000002971283


Protein motifs (from Interpro)
Interpro ID Name
 IPR004000  Actin family
 IPR004001  Actin, conserved site
 IPR029912  Actin-like protein 6A


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003407 neural retina development IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006338 chromatin remodeling IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0040008 regulation of growth IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling IEA
 biological_processGO:0043967 histone H4 acetylation IEA
 biological_processGO:0043968 histone H2A acetylation IEA
 biological_processGO:1903146 regulation of autophagy of mitochondrion ISO
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion ISO
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016514 SWI/SNF complex IEA
 cellular_componentGO:0031011 Ino80 complex IEA
 cellular_componentGO:0035267 NuA4 histone acetyltransferase complex IEA
 cellular_componentGO:0071564 npBAF complex IEA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
RMTs methylate histone arginines
UCH proteinases
DNA Damage Recognition in GG-NER
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0000334 decreased granulocyte number "fewer than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

Allelic Composition: Actl6atm1.1Grc/Actl6a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0002872 polycythemia "an excess of circulating red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0003179 decreased platelet count "fewer than the normal numbers of the non-nucleated cells found in the blood and involved in blood coagulation " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, hdene:Howard Dene , Mouse Genome Informatics Curator, J:93052]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

Allelic Composition: Actl6atm1.1Grc/Actl6a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA

 MP:0004810 decreased hematopoietic stem cell number "reduced cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0008255 decreased megakaryocyte cell number "reduced number of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

Allelic Composition: Actl6atm1.1Grc/Actl6a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA

 MP:0008973 decreased erythroid progenitor cell number "reduced numbers of progenitors of the erythrocyte lineage" [CL:0000038, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Actl6atm1.1Grc/Actl6a+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * CBA

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

 MP:0011903 decreased hematopoietic stem cell proliferation "reduction in the expansion rate of a hematopoietic stem cell population by cell division" [MGI:csmith]
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Allelic Composition: Esr1tm4.2Ksk/Esr1tm4.2Ksk
Genetic Background: involves: C57BL/6 * C57BL/6NTac * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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