ENSMUSG00000027719


Mus musculus

Features
Gene ID: ENSMUSG00000027719
  
Biological name :Adad1
  
Synonyms : Adad1 / Adenosine deaminase domain-containing protein 1 / Q5SUE7
  
Possible biological names infered from orthology : adenosine deaminase domain containing 1 / Q96M93
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: B
Gene start: 37063527
Gene end: 37121930
  
Corresponding Affymetrix probe sets: 10491678 (MoGene1.0st)   1418682_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029274
Ensembl peptide - ENSMUSP00000115260
Ensembl peptide - ENSMUSP00000121015
NCBI entrez gene - 21744     See in Manteia.
MGI - MGI:103258
RefSeq - XM_017319531
RefSeq - XM_006535435
RefSeq - XM_006535436
RefSeq - XM_006535437
RefSeq - XM_006535438
RefSeq - NM_009350
RefSeq - XM_006535433
RefSeq - XM_006535434
RefSeq Peptide - NP_033376
swissprot - F8WI80
swissprot - F6TQG5
swissprot - Q5SUE7
Ensembl - ENSMUSG00000027719
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adad1ENSDARG00000089181Danio rerio
 ADAD1ENSGALG00000044995Gallus gallus
 ADAD1ENSG00000164113Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adad2 / adenosine deaminase domain containing 2 / Q8NCV1*ENSMUSG0000002426627
Adarb2 / Q9JI20 / adenosine deaminase, RNA-specific, B2 / Q9NS39* / adenosine deaminase, RNA specific B2 (inactive)*ENSMUSG0000005255125
Adar / Q99MU3 / Mus musculus adenosine deaminase, RNA-specific (Adar), transcript variant 4, mRNA. / P55265* / adenosine deaminase, RNA specific*ENSMUSG0000002795124
Adarb1 / Q91ZS8 / Double-stranded RNA-specific editase 1 / P78563* / adenosine deaminase, RNA specific B1*ENSMUSG0000002026224
Adat1 / Q9JHI2 / Mus musculus adenosine deaminase, tRNA-specific 1 (Adat1), transcript variant 3, mRNA. / Q9BUB4* / adenosine deaminase, tRNA specific 1*ENSMUSG0000003194917


Protein motifs (from Interpro)
Interpro ID Name
 IPR002466  Adenosine deaminase/editase
 IPR014720  Double-stranded RNA-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0030154 cell differentiation IEA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0004000 adenosine deaminase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000242 impaired fertilization "defect or reduced ability in the process beginning with penetration of the secondary oocyte by the spermatozoon and completed by fusion of the male and female pronucei" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dcntm1Ioz/Dcn+
Genetic Background: either: C.Cg-Dcntm1Ioz or C3.Cg-Dcntm1Ioz

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Dcntm1Ioz/Dcn+
Genetic Background: either: C.Cg-Dcntm1Ioz or C3.Cg-Dcntm1Ioz

Allelic Composition: Adad1tm1Reb/Adad1tm1Reb
Genetic Background: involves: 129X1/SvJ * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dcntm1Ioz/Dcn+
Genetic Background: either: C.Cg-Dcntm1Ioz or C3.Cg-Dcntm1Ioz

 MP:0002687 oligozoospermia "reduced concentration of spermatozoa " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Dcntm1Ioz/Dcn+
Genetic Background: either: C.Cg-Dcntm1Ioz or C3.Cg-Dcntm1Ioz

 MP:0003020 decreased circulating chloride level "reduced concentration of chlorine salts in the circulation" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

 MP:0005578 teratozoospermia "presence of malformed spermatozoa in the semen; malformations include the physical bending of the sperm to produce kinks or bends" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dcntm1Ioz/Dcn+
Genetic Background: either: C.Cg-Dcntm1Ioz or C3.Cg-Dcntm1Ioz

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Smg9tm1b(EUCOMM)Wtsi/Smg9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Smg9tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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