ENSMUSG00000027951


Mus musculus

Features
Gene ID: ENSMUSG00000027951
  
Biological name :Adar
  
Synonyms : Adar / Mus musculus adenosine deaminase, RNA-specific (Adar), transcript variant 4, mRNA. / Q99MU3
  
Possible biological names infered from orthology : adenosine deaminase, RNA specific / P55265
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 89715022
Gene end: 89753446
  
Corresponding Affymetrix probe sets: 10493565 (MoGene1.0st)   1425405_a_at (Mouse Genome 430 2.0 Array)   1434268_at (Mouse Genome 430 2.0 Array)   1439276_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000112969
Ensembl peptide - ENSMUSP00000096525
Ensembl peptide - ENSMUSP00000103028
Ensembl peptide - ENSMUSP00000029563
Ensembl peptide - ENSMUSP00000113453
NCBI entrez gene - 56417     See in Manteia.
MGI - MGI:1889575
RefSeq - XM_006501754
RefSeq - NM_001038587
RefSeq - NM_001146296
RefSeq - NM_001357958
RefSeq - NM_019655
RefSeq - XM_006501752
RefSeq - XM_006501753
RefSeq Peptide - NP_062629
RefSeq Peptide - NP_001033676
RefSeq Peptide - NP_001139768
RefSeq Peptide - NP_001344887
swissprot - Q99MU3
Ensembl - ENSMUSG00000027951
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adarENSDARG00000012389Danio rerio
 ADARENSGALG00000021475Gallus gallus
 ADARENSG00000160710Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adarb1 / Q91ZS8 / Double-stranded RNA-specific editase 1 / P78563* / adenosine deaminase, RNA specific B1*ENSMUSG0000002026219
Adarb2 / Q9JI20 / adenosine deaminase, RNA-specific, B2 / Q9NS39* / adenosine deaminase, RNA specific B2 (inactive)*ENSMUSG0000005255119
Adad1 / Q5SUE7 / Adenosine deaminase domain-containing protein 1 / Q96M93* / adenosine deaminase domain containing 1*ENSMUSG0000002771912
Adad2 / adenosine deaminase domain containing 2 / Q8NCV1*ENSMUSG0000002426611
Adat1 / Q9JHI2 / Mus musculus adenosine deaminase, tRNA-specific 1 (Adat1), transcript variant 3, mRNA. / Q9BUB4* / adenosine deaminase, tRNA specific 1*ENSMUSG0000003194910


Protein motifs (from Interpro)
Interpro ID Name
 IPR000607  Double-stranded RNA-specific adenosine deaminase (DRADA)
 IPR002466  Adenosine deaminase/editase
 IPR014720  Double-stranded RNA-binding domain
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001649 osteoblast differentiation IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002566 somatic diversification of immune receptors via somatic mutation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006382 adenosine to inosine editing IEA
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006606 protein import into nucleus ISO
 biological_processGO:0006611 protein export from nucleus ISO
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0016553 base conversion or substitution editing IEA
 biological_processGO:0030218 erythrocyte differentiation IMP
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0031054 pre-miRNA processing IEA
 biological_processGO:0035196 production of miRNAs involved in gene silencing by miRNA IMP
 biological_processGO:0035280 miRNA loading onto RISC involved in gene silencing by miRNA IEA
 biological_processGO:0035455 response to interferon-alpha IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0060216 definitive hemopoiesis IMP
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IMP
 biological_processGO:0061484 hematopoietic stem cell homeostasis IMP
 biological_processGO:0098586 cellular response to virus IDA
 biological_processGO:1900369 negative regulation of RNA interference IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0044530 supraspliceosomal complex IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003692 left-handed Z-DNA binding TAS
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003726 double-stranded RNA adenosine deaminase activity ISO
 molecular_functionGO:0004000 adenosine deaminase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
C6 deamination of adenosine
Formation of editosomes by ADAR proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000239 deficiency of myeloid colony forming progenitor cells "lack of precursors of the myeloid cell types" [J:60630, tc:Teresa Chu , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-57J/Kit+
Genetic Background: involves: C58/J

Allelic Composition: Adartm1Phs/Adartm1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Prss16tm1Mal/Prss16+,Rag2tm1Fwa/Rag2tm1Fwa,Tg(TcraH-Y,TcrbH-Y)1Pas/?
Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: KitW-57J/Kit+
Genetic Background: involves: C58/J

Allelic Composition: Adartm1Phs/Adartm1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Adartm1.1Knk/Adartm1.1Knk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000600 liver hypoplasia "reduced size of liver due to decreased cell number " [J:57631]
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Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca

 MP:0000601 small liver "reduced size of the liver" [J:23170]
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Allelic Composition: KitW-57J/Kit+
Genetic Background: involves: C58/J

Allelic Composition: Adartm1Phs/Adartm1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001570 abnormal circulating enzyme level "aberrent concentration in the blood of any of the proteins that act as catalysts for biological reactions" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: KitW-57J/Kit+
Genetic Background: involves: C58/J

Allelic Composition: Adartm1Phs/Adartm1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0001722 pale yolk sac "bloodless yolk sac" [J:62571]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002944 increased lactate dehydrogenase level "greater than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:87714]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0003720 abnormal neural tube closure "abnormal invagination and fusion of the neuroepithelial layer in early development" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:99099]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0003795 abnormal bone structure 
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Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: KitW-57J/Kit+
Genetic Background: involves: C58/J

Allelic Composition: Adartm1Phs/Adartm1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

 MP:0004229 abnormal embryonic erythropoiesis "anomaly in the development of primarily large, nucleated erythroblasts occurring in blood islands in the yolk sac, generally occurs from E7-E11 in the mouse and through 10 weeks in humans" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0004258 abnormal placenta size "anomaly in the size or shape of the organ of metabolic interchange between fetus and mother" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0004808 abnormal hematopoietic stem cell morphology "any structural anomaly of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca

Allelic Composition: Adartm1.1Phs/Adartm2Phs,Tg(Tal1-cre/ERT)42-056Jrg/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Adartm1Knk/Adartm1Knk,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Akt3Nmf350/Akt3+
Genetic Background: C57BL/6J-Akt3Nmf350

 MP:0008550 abnormal circulating interferon-beta level "anomaly in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca

 MP:0008573 increased circulating interferon-alpha level "increase in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Runx1tm2(Runx1)Toku/Runx1tm2(Runx1)Toku
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pax3Sp-2J/Pax3Sp-2J
Genetic Background: either: C3H/HeJ-Pax3Sp-2J or (involves: C3H/HeJ * C57BL/6J)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Plp1tm1Frca/Y
Genetic Background: B6.129-Plp1tm1Frca

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: KitW-57J/Kit+
Genetic Background: involves: C58/J

Allelic Composition: Adartm1Phs/Adartm1Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Adartm2Phs/Adartm2Phs
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * NMRI

Allelic Composition: Adartm1.1Knk/Adartm1.1Knk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Adartm1Olds/Adartm1Olds
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Adartm2Knk/Adar+
Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0013293 embryonic lethality prior to tooth bud stage "death prior to the appearance of tooth buds (Mus: E12-E12.5)" [MGI:smb]
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Allelic Composition: Adartm1b(EUCOMM)Wtsi/Adartm1b(EUCOMM)Wtsi
Genetic Background: B6N(Cg)-Adartm1b(EUCOMM)Wtsi/J

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Adartm1.1Knk/Adartm1.1Knk
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027951 Adar / Q99MU3 / Mus musculus adenosine deaminase, RNA-specific (Adar), transcript variant 4, mRNA. / P55265* / adenosine deaminase, RNA specific*  / reaction / complex






 

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