ENSMUSG00000020262


Mus musculus

Features
Gene ID: ENSMUSG00000020262
  
Biological name :Adarb1
  
Synonyms : Adarb1 / Double-stranded RNA-specific editase 1 / Q91ZS8
  
Possible biological names infered from orthology : adenosine deaminase, RNA specific B1 / P78563
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 77290726
Gene end: 77418270
  
Corresponding Affymetrix probe sets: 10370303 (MoGene1.0st)   1421480_a_at (Mouse Genome 430 2.0 Array)   1434932_at (Mouse Genome 430 2.0 Array)   1443968_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000020496
Ensembl peptide - ENSMUSP00000101046
Ensembl peptide - ENSMUSP00000122102
Ensembl peptide - ENSMUSP00000114608
Ensembl peptide - ENSMUSP00000095976
Ensembl peptide - ENSMUSP00000101044
NCBI entrez gene - 110532     See in Manteia.
MGI - MGI:891999
RefSeq - XM_006513063
RefSeq - XM_006513062
RefSeq - NM_001024837
RefSeq - NM_130895
RefSeq - XM_006513065
RefSeq - XM_006513064
RefSeq Peptide - NP_570965
RefSeq Peptide - NP_001020008
swissprot - Q91ZS8
swissprot - D6RGS1
swissprot - D6RDS5
Ensembl - ENSMUSG00000020262
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 adarb1aENSDARG00000041609Danio rerio
 adarb1bENSDARG00000003544Danio rerio
 ADARB1ENSGALG00000007527Gallus gallus
 ADARB1ENSG00000197381Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Adarb2 / Q9JI20 / adenosine deaminase, RNA-specific, B2 / Q9NS39* / adenosine deaminase, RNA specific B2 (inactive)*ENSMUSG0000005255153
Adar / Q99MU3 / Mus musculus adenosine deaminase, RNA-specific (Adar), transcript variant 4, mRNA. / P55265* / adenosine deaminase, RNA specific*ENSMUSG0000002795132
Adad1 / Q5SUE7 / Adenosine deaminase domain-containing protein 1 / Q96M93* / adenosine deaminase domain containing 1*ENSMUSG0000002771921
Adad2 / adenosine deaminase domain containing 2 / Q8NCV1*ENSMUSG0000002426619
Adat1 / Q9JHI2 / Mus musculus adenosine deaminase, tRNA-specific 1 (Adat1), transcript variant 3, mRNA. / Q9BUB4* / adenosine deaminase, tRNA specific 1*ENSMUSG0000003194915


Protein motifs (from Interpro)
Interpro ID Name
 IPR002466  Adenosine deaminase/editase
 IPR014720  Double-stranded RNA-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006382 adenosine to inosine editing IEA
 biological_processGO:0006396 RNA processing ISS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0007274 neuromuscular synaptic transmission IMP
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0021610 facial nerve morphogenesis IMP
 biological_processGO:0021618 hypoglossal nerve morphogenesis IMP
 biological_processGO:0021965 spinal cord ventral commissure morphogenesis IMP
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0050884 neuromuscular process controlling posture IMP
 biological_processGO:0051726 regulation of cell cycle IEA
 biological_processGO:0060384 innervation IMP
 biological_processGO:0060415 muscle tissue morphogenesis IMP
 biological_processGO:0061744 motor behavior IMP
 biological_processGO:0097049 motor neuron apoptotic process IMP
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003723 RNA binding ISS
 molecular_functionGO:0003725 double-stranded RNA binding ISS
 molecular_functionGO:0003726 double-stranded RNA adenosine deaminase activity ISS
 molecular_functionGO:0004000 adenosine deaminase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
C6 deamination of adenosine
Formation of editosomes by ADAR proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001056 abnormal cranial nerve morphology "any anomaly, deformity, or malformation of any of the twelve nerves that emerge from the cranium as opposed to the spinal nerves" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001071 abnormal facial nerve morphology "malformed or misprojection of motor axons from the pons to the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:29973]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001076 abnormal hypoglossal nerve morphology "malformation or misprojection of motor axons to the tongue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:45302]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002064 seizures "sudden and often acute manifestation of epileptic attack, sometimes convulsive" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Myo7ash1-7J/Myo7ash1-7J
Genetic Background: STOCK Myo7ash1-7J/J

Allelic Composition: Adarb1tm1.1Eme/Adarb1tm1.1Eme
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

 MP:0002184 abnormal innervation "the malformation, misprojection or malfunction of the connection of nerve fibers with a target" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0002885 abnormal AMPA-mediated synaptic currents "change in the measured amplitude or duration of response to stimulation of AMPA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0003084 abnormal skeletal muscle fiber morphology "anomalous structure of the skeletal muscle fibers, the large multinucleated cells that make up the skeletal muscles" [smb:Susan M. Bello, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0003993 abnormal ventral spinal root morphology "any anomaly, deformity, or malformation of the anterior bundle of nerves emerging from the spinal cord to join with the posterior/dorsal nerve bundle at each spinal cord segment to form one of the 31 paired peripheral nerves" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0004263 abnormal limb posture "atypical position of the limbs compared to the normal carriage of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0005113 decreased number of anterior horn cells "fewer than the expected number of cells in the ventral gray column of the spinal cord" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0009413 skeletal muscle fiber atrophy "a wasting of skeletal muscle fibers resulting in a derangement of the skeletal muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(pb)Peli/Gt(ROSA)26Sor+,TgTn(pb-sb-ATP3)S1Brd/0
Genetic Background: involves: 129S7/SvEvBrd * FVB

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Leprdb/Leprdb
Genetic Background: involves: C57BLKS/J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Myo7ash1-7J/Myo7ash1-7J
Genetic Background: STOCK Myo7ash1-7J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000020262 Adarb1 / Q91ZS8 / Double-stranded RNA-specific editase 1 / P78563* / adenosine deaminase, RNA specific B1*  / complex / reaction






 

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