ENSMUSG00000027751


Mus musculus

Features
Gene ID: ENSMUSG00000027751
  
Biological name :Supt20
  
Synonyms : Q7TT00 / Supt20 / Transcription factor SPT20 homolog
  
Possible biological names infered from orthology : Q8NEM7 / SPT20 homolog, SAGA complex component / SUPT20H
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: C
Gene start: 54692807
Gene end: 54728766
  
Corresponding Affymetrix probe sets: 10492049 (MoGene1.0st)   1421070_at (Mouse Genome 430 2.0 Array)   1434686_at (Mouse Genome 430 2.0 Array)   1435905_at (Mouse Genome 430 2.0 Array)   1443000_at (Mouse Genome 430 2.0 Array)   1443747_at (Mouse Genome 430 2.0 Array)   1449738_s_at (Mouse Genome 430 2.0 Array)   1450116_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143059
Ensembl peptide - ENSMUSP00000143231
Ensembl peptide - ENSMUSP00000143520
Ensembl peptide - ENSMUSP00000143750
Ensembl peptide - ENSMUSP00000142648
Ensembl peptide - ENSMUSP00000142948
Ensembl peptide - ENSMUSP00000029315
Ensembl peptide - ENSMUSP00000131454
NCBI entrez gene - 56790     See in Manteia.
MGI - MGI:1929651
RefSeq - XM_006501809
RefSeq - XM_006501811
RefSeq - XM_006501812
RefSeq - XM_006501813
RefSeq - XM_006501814
RefSeq - XM_006501815
RefSeq - NM_019995
RefSeq - XM_006501810
RefSeq - XM_006501801
RefSeq - XM_006501802
RefSeq - XM_006501803
RefSeq - XM_006501804
RefSeq - XM_006501805
RefSeq - XM_006501806
RefSeq - XM_006501807
RefSeq - XM_006501808
RefSeq Peptide - NP_064379
swissprot - Z4YJG1
swissprot - A0A0G2JE63
swissprot - A0A0G2JEY3
swissprot - A0A0G2JFM5
swissprot - A0A0G2JGD1
swissprot - A0A0G2JGY6
swissprot - Q7TT00
Ensembl - ENSMUSG00000027751
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 supt20ENSDARG00000078658Danio rerio
 SUPT20HENSGALG00000017047Gallus gallus
 Q8NEM7ENSG00000102710Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR021950  Transcription factor Spt20


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007369 gastrulation IEA
 biological_processGO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter IGI
 cellular_componentGO:0000124 SAGA complex IEA
 cellular_componentGO:0001650 fibrillar center IEA
 cellular_componentGO:0070461 SAGA-type complex IEA
 molecular_functionGO:0003712 transcription coregulator activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001680 abnormal mesoderm development "failure or abnormality in the formation of the mesoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001688 abnormal somite development "anomalous formation of any of the paired, metamerically arranged cell masses formed in the embryonic paraxial mesoderm" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001689 incomplete somite formation "arrest of differentiation or patterning of the somites" [J:62882]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0001726 abnormal allantois "malformed fetal membrane which contributes to the formation of the umbilical cord and placenta" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:12622]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbiatm1Stw/Nfkbiatm1Stw
Genetic Background: involves: 129S1/Sv

 MP:0002174 abnormal gastrulation movements "failure of embryonic cells to migrate, or migrate to the appropriate target during the development and invagination of the primary germ layers" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:52418]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0002231 abnormal primitive streak morphology "anomaly in the midline ridge of the embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003054 spina bifida "common congenital midline defect of fusion of the vertebral arch" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0004073 caudal body truncation "caudal part of body truncated with anterior portion relatively normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0004180 failure of initiation of embryo turning "failure to begin the axial rotation of the germ layers of the embryo during the primitive streak/early somite stage (E8.5-E9.5)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0005224 abnormal left-right axis symmetry of the somites "anomaly in the formation or development of the somites in relation to the left and right sides of the body " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0008029 abnormal paraxial mesoderm "failure or abnormality in the formation of the mesoderm lying at either side of the midline embryonic notochord; on segmentation, paraxial mesoderm forms the paired somites" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Rarbtm1Vgi/Rarbtm1Vgi,Rxrbtm1Rev/Rxrbtm1Rev
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011257 abnormal head fold morphology "any structural anomaly of the crescent-shaped, ventrally located fold of the embryonic disc at the future cephalic end of the developing embryo; it constitutes the first body fold, and initiates brain, foregut and heart development" [ISBN:0-683-40008-8, PMID:10791309]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

 MP:0013241 embryo tissue necrosis "morphological changes resulting from pathological death of some or all embryo tissue; usually due to irreversible damage" [MGI:csmith]
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Allelic Composition: Supt20Gt(RRK304)Byg/Supt20Gt(RRK304)Byg
Genetic Background: involves: 129P2/OlaHsd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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