ENSMUSG00000027827


Mus musculus

Features
Gene ID: ENSMUSG00000027827
  
Biological name :Kcnab1
  
Synonyms : Kcnab1 / P63143 / Voltage-gated potassium channel subunit beta-1
  
Possible biological names infered from orthology : potassium voltage-gated channel subfamily A member regulatory beta subunit 1 / Q14722
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: E1
Gene start: 65109384
Gene end: 65378223
  
Corresponding Affymetrix probe sets: 10492402 (MoGene1.0st)   1448468_a_at (Mouse Genome 430 2.0 Array)   1454043_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000047480
NCBI entrez gene - 16497     See in Manteia.
MGI - MGI:109155
RefSeq - XM_006501057
RefSeq - NM_001289450
RefSeq - NM_010597
RefSeq - XM_006501056
RefSeq Peptide - NP_001276379
RefSeq Peptide - NP_034727
swissprot - P63143
Ensembl - ENSMUSG00000027827
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnab1aENSDARG00000008140Danio rerio
 kcnab1bENSDARG00000040741Danio rerio
 KCNAB1ENSGALG00000010269Gallus gallus
 KCNAB1ENSG00000169282Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnab2 / P62482 / Voltage-gated potassium channel subunit beta-2 / Q13303* / potassium voltage-gated channel subfamily A regulatory beta subunit 2*ENSMUSG0000002893171
Kcnab3 / potassium voltage-gated channel subfamily A regulatory beta subunit 3 / O43448*ENSMUSG0000001847069
Q8CG76 / Akr7a5 / Aflatoxin B1 aldehyde reductase member 2 / AKR7A2* / O43488* / aldo-keto reductase family 7 member A2*ENSMUSG0000002874323


Protein motifs (from Interpro)
Interpro ID Name
 IPR005399  Potassium channel, voltage-dependent, beta subunit, KCNAB-related
 IPR005400  Potassium channel, voltage-dependent, beta subunit, KCNAB1
 IPR005983  Potassium channel, voltage-dependent, beta subunit, KCNAB
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055114 oxidation-reduction process ISS
 biological_processGO:0060539 diaphragm development IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IMP
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IEA
 biological_processGO:1902259 regulation of delayed rectifier potassium channel activity IEA
 biological_processGO:1902260 negative regulation of delayed rectifier potassium channel activity IEA
 biological_processGO:1903817 negative regulation of voltage-gated potassium channel activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IEA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0034705 potassium channel complex IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044224 juxtaparanode region of axon IEA
 cellular_componentGO:1990635 proximal dendrite IEA
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015459 potassium channel regulator activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0070402 NADPH binding IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kcnab1tm1Sva/Kcnab1tm1Sva
Genetic Background: B6.129-Kcnab1tm1Sva

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Kcnab1tm1Mes/Kcnab1+,Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0002969 impaired social transmission of food preference "defect in the ability to recall and prefer foods associated with odors recently smelled on the breath of other mice; an indicator of defects in learning and memory of olfactory cues" [J:62218]
Show

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003008 enhanced long term potentiation "greater than the normal persistent robust synaptic response induced by synchronous stimulation of pre- and postsynaptic cells " [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, J:81922]
Show

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Mchr1tm1Yush/Mchr1tm1Yush
Genetic Background: involves: 129 * C57BL/6

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
Show

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

Allelic Composition: Kcnab1tm1Sva/Kcnab1tm1Sva
Genetic Background: B6.129-Kcnab1tm1Sva

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

 MP:0020340 abnormal inhibitory learning "anomaly in the process by which a subject learns to suppress a prior learned response" [http://cognitivedefusion.tumblr.com/post/90402024947/what-is-inhibitory-learning, ORCID: orcid.org/0000-0003-4606-0597, PMID:19321764]
Show

Allelic Composition: Itgamtm1Bll/Itgamtm1Bll
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018470 Kcnab3 / potassium voltage-gated channel subfamily A regulatory beta subunit 3 / O43448*  / complex
 ENSMUSG00000028931 Kcnab2 / P62482 / Voltage-gated potassium channel subunit beta-2 / Q13303* / potassium voltage-gated channel subfamily A regulatory beta subunit 2*  / complex
 ENSMUSG00000027827 Kcnab1 / P63143 / Voltage-gated potassium channel subunit beta-1 / Q14722* / potassium voltage-gated channel subfamily A member regulatory beta subunit 1*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr