ENSG00000169282


Homo sapiens

Features
Gene ID: ENSG00000169282
  
Biological name :KCNAB1
  
Synonyms : KCNAB1 / potassium voltage-gated channel subfamily A member regulatory beta subunit 1 / Q14722
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: q25.31
Gene start: 156037701
Gene end: 156539138
  
Corresponding Affymetrix probe sets: 208213_s_at (Human Genome U133 Plus 2.0 Array)   210078_s_at (Human Genome U133 Plus 2.0 Array)   210079_x_at (Human Genome U133 Plus 2.0 Array)   210471_s_at (Human Genome U133 Plus 2.0 Array)   231524_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418956
Ensembl peptide - ENSP00000418048
Ensembl peptide - ENSP00000419952
Ensembl peptide - ENSP00000484368
Ensembl peptide - ENSP00000420755
Ensembl peptide - ENSP00000420221
Ensembl peptide - ENSP00000305858
Ensembl peptide - ENSP00000374285
Ensembl peptide - ENSP00000374287
NCBI entrez gene - 7881     See in Manteia.
OMIM - 601141
RefSeq - XM_017007174
RefSeq - NM_001308217
RefSeq - NM_001308222
RefSeq - NM_003471
RefSeq - NM_172159
RefSeq - NM_172160
RefSeq - XM_011513115
RefSeq - XM_011513116
RefSeq - XM_011513117
RefSeq - XM_017007171
RefSeq - XM_017007172
RefSeq - XM_017007173
RefSeq Peptide - NP_001295146
RefSeq Peptide - NP_003462
RefSeq Peptide - NP_751891
RefSeq Peptide - NP_751892
RefSeq Peptide - NP_001295151
swissprot - H7C4S9
swissprot - A0A087X1P8
swissprot - Q14722
swissprot - C9JQ60
swissprot - C9JBV8
swissprot - B7Z8E5
swissprot - F8W6W4
Ensembl - ENSG00000169282
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnab1aENSDARG00000008140Danio rerio
 kcnab1bENSDARG00000040741Danio rerio
 KCNAB1ENSGALG00000010269Gallus gallus
 Kcnab1ENSMUSG00000027827Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
KCNAB2 / Q13303 / potassium voltage-gated channel subfamily A regulatory beta subunit 2ENSG0000006942468
KCNAB3 / O43448 / potassium voltage-gated channel subfamily A regulatory beta subunit 3ENSG0000017004962
AKR7A2 / O43488 / aldo-keto reductase family 7 member A2ENSG0000005337121
AKR7A3 / O95154 / aldo-keto reductase family 7 member A3ENSG0000016248221
AKR7L / Q8NHP1 / aldo-keto reductase family 7 like (gene/pseudogene)ENSG0000021145420


Protein motifs (from Interpro)
Interpro ID Name
 IPR005399  Potassium channel, voltage-dependent, beta subunit, KCNAB-related
 IPR005400  Potassium channel, voltage-dependent, beta subunit, KCNAB1
 IPR005983  Potassium channel, voltage-dependent, beta subunit, KCNAB
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007519 skeletal muscle tissue development IEA
 biological_processGO:0007611 learning or memory IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0045445 myoblast differentiation IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055114 oxidation-reduction process ISS
 biological_processGO:0060539 diaphragm development IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1901016 regulation of potassium ion transmembrane transporter activity IEA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport IDA
 biological_processGO:1902259 regulation of delayed rectifier potassium channel activity ISS
 biological_processGO:1902260 negative regulation of delayed rectifier potassium channel activity IEA
 biological_processGO:1903817 negative regulation of voltage-gated potassium channel activity IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0008076 voltage-gated potassium channel complex IMP
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane IDA
 cellular_componentGO:0032839 dendrite cytoplasm IEA
 cellular_componentGO:0034705 potassium channel complex IDA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044224 juxtaparanode region of axon IEA
 cellular_componentGO:1990635 proximal dendrite IEA
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity ISS
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0015459 potassium channel regulator activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019904 protein domain specific binding IPI
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0070402 NADPH binding IDA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000170049 KCNAB3 / O43448 / potassium voltage-gated channel subfamily A regulatory beta subunit 3  / complex
 ENSG00000069424 KCNAB2 / Q13303 / potassium voltage-gated channel subfamily A regulatory beta subunit 2  / complex
 ENSG00000169282 KCNAB1 / Q14722 / potassium voltage-gated channel subfamily A member regulatory beta subunit 1  / complex






 

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