ENSG00000053371


Homo sapiens

Features
Gene ID: ENSG00000053371
  
Biological name :AKR7A2
  
Synonyms : AKR7A2 / aldo-keto reductase family 7 member A2 / O43488
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p36.13
Gene start: 19303965
Gene end: 19312146
  
Corresponding Affymetrix probe sets: 202139_at (Human Genome U133 Plus 2.0 Array)   214259_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000339084
Ensembl peptide - ENSP00000235835
Ensembl peptide - ENSP00000417891
Ensembl peptide - ENSP00000419936
NCBI entrez gene - 8574     See in Manteia.
OMIM - 603418
RefSeq - NM_001320979
RefSeq - NM_003689
RefSeq Peptide - NP_001307908
RefSeq Peptide - NP_003680
swissprot - V9HWA2
swissprot - H3BLU7
swissprot - H7C4Q7
swissprot - H7C5H7
swissprot - O43488
Ensembl - ENSG00000053371
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 akr7a3ENSDARG00000016649Danio rerio
 ENSGALG00000004005Gallus gallus
 Akr7a5ENSMUSG00000028743Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AKR7L / Q8NHP1 / aldo-keto reductase family 7 like (gene/pseudogene)ENSG0000021145482
AKR7A3 / O95154 / aldo-keto reductase family 7 member A3ENSG0000016248281
KCNAB3 / O43448 / potassium voltage-gated channel subfamily A regulatory beta subunit 3ENSG0000017004924
KCNAB2 / Q13303 / potassium voltage-gated channel subfamily A regulatory beta subunit 2ENSG0000006942424
KCNAB1 / Q14722 / potassium voltage-gated channel subfamily A member regulatory beta subunit 1ENSG0000016928224


Protein motifs (from Interpro)
Interpro ID Name
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process TAS
 biological_processGO:0006081 cellular aldehyde metabolic process TAS
 biological_processGO:0006805 xenobiotic metabolic process TAS
 biological_processGO:0022900 electron transport chain IEA
 biological_processGO:0044597 daunorubicin metabolic process IMP
 biological_processGO:0044598 doxorubicin metabolic process IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0004032 alditol:NADP+ 1-oxidoreductase activity TAS
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009055 electron transfer activity TAS
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019119 phenanthrene-9,10-epoxide hydrolase activity IDA


Pathways (from Reactome)
Pathway description
Aflatoxin activation and detoxification


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000053371 AKR7A2 / O43488 / aldo-keto reductase family 7 member A2  / complex






 

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