ENSMUSG00000028931


Mus musculus

Features
Gene ID: ENSMUSG00000028931
  
Biological name :Kcnab2
  
Synonyms : Kcnab2 / P62482 / Voltage-gated potassium channel subunit beta-2
  
Possible biological names infered from orthology : potassium voltage-gated channel subfamily A regulatory beta subunit 2 / Q13303
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: E2
Gene start: 152390742
Gene end: 152477871
  
Corresponding Affymetrix probe sets: 10518927 (MoGene1.0st)   1416956_at (Mouse Genome 430 2.0 Array)   1425885_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000124588
Ensembl peptide - ENSMUSP00000124156
Ensembl peptide - ENSMUSP00000125058
Ensembl peptide - ENSMUSP00000125270
Ensembl peptide - ENSMUSP00000030768
Ensembl peptide - ENSMUSP00000101273
Ensembl peptide - ENSMUSP00000123939
NCBI entrez gene - 16498     See in Manteia.
MGI - MGI:109239
RefSeq - XM_017319997
RefSeq - NM_010598
RefSeq - XM_006538583
RefSeq - XM_006538584
RefSeq - XM_006538585
RefSeq - XM_006538586
RefSeq - XM_006538587
RefSeq - XM_011250197
RefSeq - XM_011250198
RefSeq - XM_011250199
RefSeq - XM_017319996
RefSeq - NM_001252654
RefSeq - NM_001252655
RefSeq - NM_001252656
RefSeq Peptide - NP_034728
RefSeq Peptide - NP_001239583
RefSeq Peptide - NP_001239584
RefSeq Peptide - NP_001239585
RefSeq Peptide - NP_001342101
swissprot - E0CXI4
swissprot - E0CXZ9
swissprot - P62482
swissprot - Q3UPV6
swissprot - E0CYS2
Ensembl - ENSMUSG00000028931
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 kcnab2aENSDARG00000087247Danio rerio
 kcnab2bENSDARG00000062134Danio rerio
 KCNAB2ENSGALG00000037241Gallus gallus
 KCNAB2ENSG00000069424Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Kcnab1 / P63143 / Voltage-gated potassium channel subunit beta-1 / Q14722* / potassium voltage-gated channel subfamily A member regulatory beta subunit 1*ENSMUSG0000002782778
Kcnab3 / potassium voltage-gated channel subfamily A regulatory beta subunit 3 / O43448*ENSMUSG0000001847068
Q8CG76 / Akr7a5 / Aflatoxin B1 aldehyde reductase member 2 / AKR7A2* / O43488* / aldo-keto reductase family 7 member A2*ENSMUSG0000002874325


Protein motifs (from Interpro)
Interpro ID Name
 IPR005399  Potassium channel, voltage-dependent, beta subunit, KCNAB-related
 IPR005401  Potassium channel, voltage-dependent, beta subunit, KCNAB2
 IPR005983  Potassium channel, voltage-dependent, beta subunit, KCNAB
 IPR023210  NADP-dependent oxidoreductase domain
 IPR036812  NADP-dependent oxidoreductase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IGI
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0050905 neuromuscular process IMP
 biological_processGO:0055114 oxidation-reduction process ISS
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070995 NADPH oxidation ISS
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:1901379 regulation of potassium ion transmembrane transport ISS
 biological_processGO:2000008 regulation of protein localization to cell surface ISS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule ISS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0008076 voltage-gated potassium channel complex ISO
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0031234 extrinsic component of cytoplasmic side of plasma membrane ISS
 cellular_componentGO:0034705 potassium channel complex ISS
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0043679 axon terminus IDA
 cellular_componentGO:0044224 juxtaparanode region of axon IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:1990031 pinceau fiber ISS
 molecular_functionGO:0004033 aldo-keto reductase (NADP) activity ISS
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015459 potassium channel regulator activity ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
Voltage gated Potassium channels
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

Allelic Composition: Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: B6.129S7-Kcnab2tm1Kmc

Allelic Composition: Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0000951 sporadic seizures "occasional seizures occuring at irregular intervals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

Allelic Composition: Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: B6.129S7-Kcnab2tm1Kmc

Allelic Composition: Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Kcnab1tm1Mes/Kcnab1tm1Mes,Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Kcnab1tm1Mes/Kcnab1+,Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

 MP:0003412 abnormal afterhyperpolarization "anomaly in the currents that follow an action potential and influence firing frequency and neuronal integration" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94941]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

 MP:0009454 impaired contextual conditioning "decrease in the ability of an animal to learn and remember an association between an aversive experience (the unconditioned stimulus (US), usually a shock) and the neutral, unchanging environment (the conditioned stimulus (CS), or the environmental context in this case)" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

 MP:0011014 decreased core body temperature "reduced degree of heat natural to the internal center of a living being" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Tc/Tc,tw5/tw5
Genetic Background: mixed

Allelic Composition: Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Kcnab2tm1Kmc/Kcnab2tm1Kmc
Genetic Background: B6.129S7-Kcnab2tm1Kmc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018470 Kcnab3 / potassium voltage-gated channel subfamily A regulatory beta subunit 3 / O43448*  / complex
 ENSMUSG00000027827 Kcnab1 / P63143 / Voltage-gated potassium channel subunit beta-1 / Q14722* / potassium voltage-gated channel subfamily A member regulatory beta subunit 1*  / complex
 ENSMUSG00000028931 Kcnab2 / P62482 / Voltage-gated potassium channel subunit beta-2 / Q13303* / potassium voltage-gated channel subfamily A regulatory beta subunit 2*  / complex






 

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