ENSMUSG00000027861


Mus musculus

Features
Gene ID: ENSMUSG00000027861
  
Biological name :Casq2
  
Synonyms : Casq2 / Mus musculus calsequestrin 2 (Casq2), transcript variant 1, mRNA. / O09161
  
Possible biological names infered from orthology : calsequestrin 2 / O14958
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.2
Gene start: 102086415
Gene end: 102146514
  
Corresponding Affymetrix probe sets: 10494804 (MoGene1.0st)   1422529_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000131232
Ensembl peptide - ENSMUSP00000029454
Ensembl peptide - ENSMUSP00000130482
NCBI entrez gene - 12373     See in Manteia.
MGI - MGI:1309469
RefSeq - NM_009814
RefSeq - XM_006500947
RefSeq - NM_001355663
RefSeq Peptide - NP_001342592
RefSeq Peptide - NP_033944
swissprot - E9PZ67
swissprot - O09161
swissprot - F6QYE1
Ensembl - ENSMUSG00000027861
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 casq2ENSDARG00000008982Danio rerio
 CASQ2ENSGALG00000015018Gallus gallus
 CASQ2ENSG00000118729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Casq1 / O09165 / Calsequestrin-1 / P31415*ENSMUSG0000000712260


Protein motifs (from Interpro)
Interpro ID Name
 IPR001393  Calsequestrin
 IPR018233  Calsequestrin, conserved site
 IPR036249  Thioredoxin-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IMP
 biological_processGO:0006937 regulation of muscle contraction TAS
 biological_processGO:0010649 regulation of cell communication by electrical coupling IEA
 biological_processGO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IMP
 biological_processGO:0010881 regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion IMP
 biological_processGO:0043267 negative regulation of potassium ion transport IDA
 biological_processGO:0045214 sarcomere organization IMP
 biological_processGO:0051208 sequestering of calcium ion IEA
 biological_processGO:0051258 protein polymerization IEA
 biological_processGO:0060048 cardiac muscle contraction IEA
 biological_processGO:0060306 regulation of membrane repolarization IDA
 biological_processGO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity IEA
 biological_processGO:0071313 cellular response to caffeine IEA
 biological_processGO:1901017 negative regulation of potassium ion transmembrane transporter activity IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016529 sarcoplasmic reticulum TAS
 cellular_componentGO:0030018 Z disc IDA
 cellular_componentGO:0030314 junctional membrane complex IDA
 cellular_componentGO:0033018 sarcoplasmic reticulum lumen IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Ion homeostasis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
Show

Allelic Composition: Cdkn2atm1Rdp/Cdkn2atm1Rdp,Tg(Tyr-BRAF*V600E)476Fgh/0
Genetic Background: involves: 129/Sv * C57BL/6J * CBA * SJL

Allelic Composition: Casq2tm2.1Sgp/Casq2tm2.1Sgp
Genetic Background: involves: 129

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Bap1tm1a(EUCOMM)Hmgu/Bap1+
Genetic Background: C57BL/6N-Bap1tm1a(EUCOMM)Hmgu/Wtsi

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

 MP:0002625 left ventricle hypertrophy "increased size of the left ventricle" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rdh5tm1Wsb/Rdh5tm1Wsb
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0002953 thick ventricular wall "increased depth of the cardiac wall of the heart ventricles" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003929 decreased heart rate variability "reduced variation of beat-to-beat intervals of the heart, usually indicitive of cardiac disease" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0004088 abnormal sarcoplasmic reticulum morphology "any structural abnormality in the endoplasmic reticulum of skeletal and cardiac muscle, i.e. the complex of vesicles, tubules, and cisternae that form a continuous structure around striated myofibrils, with a repetition of structure within each sarcomere " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Casq2tm2.1Sgp/Casq2tm2.1Sgp
Genetic Background: involves: 129

 MP:0004122 sinus arrhythmia "irregular heartbeat related to abnormal function of the sinoatrial node" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

Allelic Composition: Casq2tm1.1Sgp/Casq2tm1.1Sgp
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrL

 MP:0004485 increased response of heart to induced stress "increase in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0005385 cardiovascular system phenotype 
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0008725 enlarged heart atrium "increased size of one or both of the two upper chambers of the heart, to which the blood returns from the circulation" [MESH:A07.541.358]
Show

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

 MP:0008950 ventricular tachycardia "paroxysmal rapid beating of the heart originating in an ectopic focus in the heart ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

Allelic Composition: Casq2tm1.1Sgp/Casq2tm1.1Sgp
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrL

Allelic Composition: Casq2tm2.1Sgp/Casq2tm2.1Sgp
Genetic Background: involves: 129

 MP:0009732 ventricular premature beat "a heartbeat is initiated by abnormal electrical activation originating in the heart ventricles rather than by the sinoatrial node, the normal heartbeat initiator, before a normal heartbeat would occur" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casq2tm1Jse/Casq2tm1Jse
Genetic Background: involves: FVB/N

Allelic Composition: Casq2tm2Jse/Casq2tm2Jse
Genetic Background: Not Specified

Allelic Composition: Casq2tm1.1Sgp/Casq2tm1.1Sgp
Genetic Background: involves: 129X1/SvJ * C57BL/6NCrL

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Casq2tm1b(KOMP)Wtsi/Casq2+
Genetic Background: C57BL/6N-Casq2tm1b(KOMP)Wtsi/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Cacna1stm1.1(KOMP)Vlcg/Cacna1stm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Cacna1stm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027861 Casq2 / O09161 / Mus musculus calsequestrin 2 (Casq2), transcript variant 1, mRNA. / O14958* / calsequestrin 2*  / -






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr