ENSMUSG00000027968


Mus musculus

Features
Gene ID: ENSMUSG00000027968
  
Biological name :Larp7
  
Synonyms : La-related protein 7 / Larp7 / Q05CL8
  
Possible biological names infered from orthology : La ribonucleoprotein domain family member 7 / Q4G0J3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: G2
Gene start: 127536714
Gene end: 127553349
  
Corresponding Affymetrix probe sets: 10502029 (MoGene1.0st)   10514383 (MoGene1.0st)   1428310_at (Mouse Genome 430 2.0 Array)   1429558_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000143331
Ensembl peptide - ENSMUSP00000029588
NCBI entrez gene - 28036     See in Manteia.
MGI - MGI:107634
RefSeq - NM_138593
RefSeq Peptide - NP_613059
swissprot - A0A0G2JFW4
swissprot - Q05CL8
Ensembl - ENSMUSG00000027968
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 larp7ENSDARG00000017315Danio rerio
 LARP7ENSGALG00000012048Gallus gallus
 LARP7ENSG00000174720Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Gm12666 / LARP7* / Q4G0J3* / La ribonucleoprotein domain family member 7*ENSMUSG0000006610744
Larp6 / Q8BN59 / La-related protein 6 / Q9BRS8* / La ribonucleoprotein domain family member 6*ENSMUSG0000003483916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR002344  Lupus La protein
 IPR006630  La-type HTH domain
 IPR014886  La protein, RNA-binding domain
 IPR034887  LARP7, RNA recognition motif 1
 IPR034910  LARP7, RNA recognition motif 2
 IPR034946  La-related protein 7, La domain
 IPR035979  RNA-binding domain superfamily
 IPR036388  Winged helix-like DNA-binding domain superfamily
 IPR036390  Winged helix DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IGI
 biological_processGO:0006396 RNA processing IEA
 biological_processGO:0035562 negative regulation of chromatin binding IGI
 biological_processGO:0036093 germ cell proliferation IMP
 biological_processGO:1900087 positive regulation of G1/S transition of mitotic cell cycle IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008390 abnormal primordial germ cell proliferation "anomaly in the ability of the primordial germ cell population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008392 decreased primordial germ cell number "reduced number of a mesodermally-derived, most primitive undifferentiated sex cell, that originates in the allantois and migrates through the hindgut and into the gonadal ridge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Mthfrtm1Rzn/Mthfrtm1Rzn
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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