ENSMUSG00000028080


Mus musculus

Features
Gene ID: ENSMUSG00000028080
  
Biological name :Lrba
  
Synonyms : LPS responsive beige-like anchor protein / Lrba
  
Possible biological names infered from orthology : P50851
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F1
Gene start: 86224680
Gene end: 86782692
  
Corresponding Affymetrix probe sets: 10492890 (MoGene1.0st)   1425717_at (Mouse Genome 430 2.0 Array)   1436690_at (Mouse Genome 430 2.0 Array)   1449099_at (Mouse Genome 430 2.0 Array)   1451887_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148618
Ensembl peptide - ENSMUSP00000103261
Ensembl peptide - ENSMUSP00000141734
Ensembl peptide - ENSMUSP00000142043
Ensembl peptide - ENSMUSP00000142179
NCBI entrez gene - 80877     See in Manteia.
MGI - MGI:1933162
RefSeq - XM_006502354
RefSeq - NM_030695
RefSeq - XM_006502347
RefSeq - XM_006502348
RefSeq - XM_006502349
RefSeq - XM_006502350
RefSeq - XM_006502351
RefSeq - XM_006502352
RefSeq - XM_006502353
RefSeq - NM_001077687
RefSeq - NM_001077688
RefSeq Peptide - NP_109620
RefSeq Peptide - NP_001071155
RefSeq Peptide - NP_001071156
swissprot - E9Q3Y4
swissprot - A0A0A6YXL6
swissprot - Q8BSM6
swissprot - A0A1D5RM41
swissprot - A0A0A6YXX3
Ensembl - ENSMUSG00000028080
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lrbaENSDARG00000031108Danio rerio
 LRBAENSGALG00000010061Gallus gallus
 LRBAENSG00000198589Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nbea / Q9EPN1 / Neurobeachin / Q8NFP9*ENSMUSG0000002779965
Nbeal2 / Q6ZQA0 / Neurobeachin-like protein 2 / Q6ZNJ1* / neurobeachin like 2*ENSMUSG0000005672419
Nbeal1 / neurobeachin like 1 / Q6ZS30*ENSMUSG0000007366418
Wdfy3 / Q6VNB8 / WD repeat and FYVE domain containing 3 / Q8IZQ1*ENSMUSG0000004394016
Lyst / lysosomal trafficking regulator / Q99698*ENSMUSG0000001972616
Wdfy4 / WD repeat and FYVE domain containing 4 / Q6ZS81* / WDFY family member 4*ENSMUSG0000005150615
Nsmaf / O35242 / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*ENSMUSG000000282459
Wdr81 / Q5ND34 / WD repeat domain 81 / Q562E7*ENSMUSG000000453749


Protein motifs (from Interpro)
Interpro ID Name
 IPR000409  BEACH domain
 IPR001680  WD40 repeat
 IPR010508  Domain of unknown function DUF1088
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR023362  PH-BEACH domain
 IPR031570  Domain of unknown function DUF4704
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036372  BEACH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0004973 increased regulatory T cell number "greater number of the specialized subpopulation of T cells that act to suppress activation of the immune system and thus maintain immune system homeostasis and prevent pathological self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0005673 decreased susceptibility to graft versus host disease "less likelihood of developing clinical symptoms of anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the a graft versus host reaction, which is an immunological attack mounted by a graft against the host because of tissue incompatibility when immunologically competent cells are transplanted to an immunologically incompetent host" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator, J:52834]
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Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

 MP:0013663 increased myeloid cell number "greater than the expected number of cells of the myeloid lineage" [CL:0000763]
Show

Allelic Composition: Gnptabtm1Dkji/Gnptabtm1Dkji
Genetic Background: involves: 129 * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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