Manteia - Molecule gene

ENSMUSG00000043940

Mus musculus

Features

Gene ID:	ENSMUSG00000043940

Biological name :	Wdfy3

Synonyms :	Q6VNB8 / Wdfy3 / WD repeat and FYVE domain containing 3

Possible biological names infered from orthology :	Q8IZQ1

Species:	Mus musculus

Chr. number:	5
Strand:	-1
Band:	E5
Gene start:	101832956
Gene end:	102069921

Corresponding Affymetrix probe sets:	10531794 (MoGene1.0st) 10531796 (MoGene1.0st) 1427456_at (Mouse Genome 430 2.0 Array) 1428517_at (Mouse Genome 430 2.0 Array) 1446109_at (Mouse Genome 430 2.0 Array) 1447433_at (Mouse Genome 430 2.0 Array) 1458952_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000133979 Ensembl peptide - ENSMUSP00000134541 Ensembl peptide - ENSMUSP00000148521 Ensembl peptide - ENSMUSP00000052607 Ensembl peptide - ENSMUSP00000134244 NCBI entrez gene - 72145 See in Manteia. MGI - MGI:1096875 RefSeq - XM_006535228 RefSeq - XM_006535223 RefSeq - XM_006535224 RefSeq - XM_006535225 RefSeq - XM_006535226 RefSeq - XM_006535227 RefSeq - NM_172882 RefSeq - XM_006535220 RefSeq - XM_006535221 RefSeq - XM_006535222 RefSeq Peptide - NP_766470 swissprot - G3UYW1 swissprot - G3UY81 swissprot - A0A1D5RLV7 swissprot - Q6VNB8 Ensembl - ENSMUSG00000043940

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
wdfy3	ENSDARG00000078890	Danio rerio
WDFY3	ENSG00000163625	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Wdfy4 / WD repeat and FYVE domain containing 4 / Q6ZS81* / WDFY family member 4*	ENSMUSG00000051506	32
Lyst / lysosomal trafficking regulator / Q99698*	ENSMUSG00000019726	17
Nbeal1 / neurobeachin like 1 / Q6ZS30*	ENSMUSG00000073664	16
Nbeal2 / Q6ZQA0 / Neurobeachin-like protein 2 / Q6ZNJ1* / neurobeachin like 2*	ENSMUSG00000056724	16
Lrba / LPS responsive beige-like anchor protein / P50851*	ENSMUSG00000028080	13
Nbea / Q9EPN1 / Neurobeachin / Q8NFP9*	ENSMUSG00000027799	13
Nsmaf / O35242 / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*	ENSMUSG00000028245	7
Wdr81 / Q5ND34 / WD repeat domain 81 / Q562E7*	ENSMUSG00000045374	7

Protein motifs (from Interpro)

Interpro ID	Name
IPR000306	FYVE zinc finger
IPR000409	BEACH domain
IPR001680	WD40 repeat
IPR011011	Zinc finger, FYVE/PHD-type
IPR011989	Armadillo-like helical
IPR011993	PH-like domain superfamily
IPR013083	Zinc finger, RING/FYVE/PHD-type
IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
IPR015943	WD40/YVTN repeat-like-containing domain superfamily
IPR016024	Armadillo-type fold
IPR017455	Zinc finger, FYVE-related
IPR017986	WD40-repeat-containing domain
IPR019775	WD40 repeat, conserved site
IPR023362	PH-BEACH domain
IPR031570	Domain of unknown function DUF4704
IPR036322	WD40-repeat-containing domain superfamily
IPR036372	BEACH domain superfamily

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006914	autophagy	IEA
biological_process	GO:0007275	multicellular organism development	IEA
biological_process	GO:0035973	aggrephagy	ISO
cellular_component	GO:0005634	nucleus	ISO
cellular_component	GO:0005635	nuclear envelope	ISO
cellular_component	GO:0005730	nucleolus	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005776	autophagosome	ISO
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016234	inclusion body	ISS
cellular_component	GO:0016605	PML body	ISS
cellular_component	GO:0019898	extrinsic component of membrane	ISO
cellular_component	GO:0030424	axon	IEA
cellular_component	GO:0034274	Atg12-Atg5-Atg16 complex	ISO
cellular_component	GO:0042995	cell projection	IEA
cellular_component	GO:0043204	perikaryon	IEA
cellular_component	GO:0097635	extrinsic component of autophagosome membrane	IDA
molecular_function	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity	IDA
molecular_function	GO:0005488	binding	IEA
molecular_function	GO:0005515	protein binding	IEA
molecular_function	GO:0005545	1-phosphatidylinositol binding	ISO
molecular_function	GO:0008289	lipid binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0000790	abnormal stratification in cerebral cortex	"abnormal formation or pattern of the layers of the cerebral cortex " [J:64289, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0000859	abnormal somatosensory cortex morphology	"any malformation or absence of the area of the parietal lobe that lies posterior to the central sulcus and is concerned with receiving and processing general sensations from the body surface" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3⁺ Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0002741	small olfactory bulb	"reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0003077	abnormal cell cycle	"failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0003232	abnormal forebrain development	"anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0003424	premature neuronal precursor differentiation	"earlier than normal transformation of neuronal precursor cells into neurons" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94391]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0004274	abnormal embryonic/fetal subventricular zone morphology	"any structural anomaly in the transient proliferative population of neurons that expands exponentially during late prenatal development; it is a continuous germinal zone distinct from the ventricular zone that surrounds the brain ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0004276	abnormal medial ganglionic eminence morphology	"any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the neocortex; however, hippocampal neurons, thalamus, septum and olfactory bulb neurons are also partly derived from the MGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0004277	abnormal lateral ganglionic eminence morphology	"any structural anomaly of a distinct elevation of a transient proliferating cell mass of the fetal subventricular zone; this mass contributes most of its cells to the striatum; however, neocortex, thalamus, septum and olfactory bulb neurons are also partly derived from the LGE" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0004948	abnormal neuronal precursor proliferation	"any anomaly in the ability of a neuroblast population to undergo rapid expansion by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0004981	decreased neuronal precursor cell number	"reduced number of the neuroblast embryonic cells that develop into nerve cells or neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0006009	abnormal neuronal migration	"defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0006254	thin cerebral cortex	"decreased depth of the mantle covering the surface of the cerebral hemispheres" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:84683]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0008443	absent subplate	"absence of the transient outer neural tube region that contains the first generated post-mitotic neurons that receive synaptic input from thalamic axons and in turn project axons to the developing cortical plate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:8210173]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0008457	abnormal cortical intermediate zone morphology	"any structural anomaly of the region of the developing mammalian cortex that extends between the ventricular zone and the cortical plate (CP); normally, the IZ is a region of tangential migration of cells, and at midgestation, the lower part of the IZ develops into the subventricular zone" [PMID:10632599]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0008458	abnormal cortical ventricular zone morphology	"any structural anomaly of a transient region of the developing cerebral cortex that contains migrating neurons, radial glial cells, and a large population of cycling multipotent neural stem cells that generate newborn neurons" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0008536	enlarged third ventricle	"increased size of the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [MESH:A08.186.211.276.840, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0008540	abnormal cerebrum morphology	"any structural anomaly of the largest part of the brain, derived from the telencephalon, and is composed of a right and a left hemisphere each which contains an outer cerebral cortex and a subcortical basal ganglia; cerebral functions include sensorimotor, emotional, and intellectual activities" [MESH:A08.186.211.730.885.287]	Show Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0008547	abnormal neocortex morphology	"any structural anomaly of the larger part of the mammalian cerebral cortex, distinguished from the allocortex by being composed of a larger number of nerve cells arranged in six layers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MESH:A08.186.211.730.885.213.420]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp} Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3⁺ Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0011089	complete perinatal lethality	"death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0011724	ectopic cortical neuron	"appearance of a cerebral cortical neuron or group of cerebral cortical neurons in a region where it is not normally found" [MGI:csmith]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N Allelic Composition: Wdfy3^{tm1a(KOMP)Mbp}/Wdfy3^{tm1a(KOMP)Mbp} Genetic Background: C57BL/6N-Wdfy3^{tm1a(KOMP)Mbp}
MP:0012139	increased forebrain size	"greater than average size of the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)" [GO:0048853]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0020067	increased neocortex size	"greater than average size of the neocortex" [GOC:NV]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N
MP:0020389	increased radial glial cell number	"increase in the number of the supporting cells of the developing central nervous system that guide neuronal migration during development and exchange metabolites with developing and migrating neurons; these cells differentiate into astrocytes and some neuronal types in the adult" [MGI:anna, PMID:25100583]	Show Allelic Composition: Ddr2^{tm1c(EUCOMM)Wtsi}/Ddr2^{tm1c(EUCOMM)Wtsi},Tg(KRT14-cre)1Amc/0,Tg(MMTV-PyVT)634Mul/0 Genetic Background: involves: C57BL/6 * C57BL/6N * CBA * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

External programs and data are copyrighted by and are the property of their respective authors. The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation
		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr