ENSG00000163625


Homo sapiens

Features
Gene ID: ENSG00000163625
  
Biological name :WDFY3
  
Synonyms : Q8IZQ1 / WDFY3 / WD repeat and FYVE domain containing 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: q21.23
Gene start: 84669610
Gene end: 84966391
  
Corresponding Affymetrix probe sets: 212598_at (Human Genome U133 Plus 2.0 Array)   212602_at (Human Genome U133 Plus 2.0 Array)   212606_at (Human Genome U133 Plus 2.0 Array)   238660_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000426813
Ensembl peptide - ENSP00000295888
Ensembl peptide - ENSP00000422741
Ensembl peptide - ENSP00000424987
Ensembl peptide - ENSP00000425699
NCBI entrez gene - 23001     See in Manteia.
OMIM - 617485
RefSeq - XM_017007909
RefSeq - XM_011531763
RefSeq - XM_011531764
RefSeq - XM_011531765
RefSeq - XM_011531766
RefSeq - XM_017007906
RefSeq - XM_017007907
RefSeq - XM_017007908
RefSeq - NM_014991
RefSeq - XM_005262858
RefSeq - XM_011531757
RefSeq - XM_011531759
RefSeq - XM_011531760
RefSeq - XM_011531761
RefSeq - XM_011531762
RefSeq Peptide - NP_055806
swissprot - A0A1D5RMR8
swissprot - H0Y9T6
swissprot - D6RJE4
swissprot - A0A024RDI0
swissprot - Q8IZQ1
swissprot - H0YAD8
Ensembl - ENSG00000163625
  
Related genetic diseases (OMIM): 617520 - ?Microcephaly 18, primary, autosomal dominant, 617520
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wdfy3ENSDARG00000078890Danio rerio
 Wdfy3ENSMUSG00000043940Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
WDFY4 / Q6ZS81 / WDFY family member 4ENSG0000012881532
LYST / Q99698 / lysosomal trafficking regulatorENSG0000014366917
NBEAL2 / Q6ZNJ1 / neurobeachin like 2ENSG0000016079616
NBEAL1 / Q6ZS30 / neurobeachin like 1ENSG0000014442616
NBEA / Q8NFP9 / neurobeachinENSG0000017291513
LRBA / P50851 / LPS responsive beige-like anchor proteinENSG0000019858913
WDR81 / Q562E7 / WD repeat domain 81ENSG000001677168
NSMAF / Q92636 / neutral sphingomyelinase activation associated factorENSG000000356817


Protein motifs (from Interpro)
Interpro ID Name
 IPR000306  FYVE zinc finger
 IPR000409  BEACH domain
 IPR001680  WD40 repeat
 IPR011011  Zinc finger, FYVE/PHD-type
 IPR011042  Six-bladed beta-propeller, TolB-like
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR016024  Armadillo-type fold
 IPR017455  Zinc finger, FYVE-related
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR023362  PH-BEACH domain
 IPR031570  Domain of unknown function DUF4704
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036372  BEACH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0035973 aggrephagy IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005635 nuclear envelope IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005776 autophagosome IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016234 inclusion body IDA
 cellular_componentGO:0016605 PML body IEA
 cellular_componentGO:0019898 extrinsic component of membrane IDA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0034274 Atg12-Atg5-Atg16 complex IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0097635 extrinsic component of autophagosome membrane IEA
 molecular_functionGO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005545 1-phosphatidylinositol binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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