ENSMUSG00000019726


Mus musculus

Features
Gene ID: ENSMUSG00000019726
  
Biological name :Lyst
  
Synonyms : lysosomal trafficking regulator / Lyst
  
Possible biological names infered from orthology : Q99698
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A1
Gene start: 13590397
Gene end: 13778803
  
Corresponding Affymetrix probe sets: 10403604 (MoGene1.0st)   1421384_at (Mouse Genome 430 2.0 Array)   1425973_at (Mouse Genome 430 2.0 Array)   1434674_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106188
Ensembl peptide - ENSMUSP00000155251
NCBI entrez gene - 17101     See in Manteia.
MGI - MGI:107448
RefSeq - NM_010748
RefSeq - XM_006516561
RefSeq - XM_006516562
RefSeq Peptide - NP_034878
swissprot - G5E8Q0
Ensembl - ENSMUSG00000019726
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lystENSDARG00000008575Danio rerio
 LYSTENSGALG00000032840Gallus gallus
 LYSTENSG00000143669Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wdfy3 / Q6VNB8 / WD repeat and FYVE domain containing 3 / Q8IZQ1*ENSMUSG0000004394016
Nbeal1 / neurobeachin like 1 / Q6ZS30*ENSMUSG0000007366415
Nbeal2 / Q6ZQA0 / Neurobeachin-like protein 2 / Q6ZNJ1* / neurobeachin like 2*ENSMUSG0000005672415
Wdfy4 / WD repeat and FYVE domain containing 4 / Q6ZS81* / WDFY family member 4*ENSMUSG0000005150614
Nbea / Q9EPN1 / Neurobeachin / Q8NFP9*ENSMUSG0000002779913
Lrba / LPS responsive beige-like anchor protein / P50851*ENSMUSG0000002808012
Wdr81 / Q5ND34 / WD repeat domain 81 / Q562E7*ENSMUSG000000453746
Nsmaf / O35242 / neutral sphingomyelinase (N-SMase) activation associated factor / Q92636* / neutral sphingomyelinase activation associated factor*ENSMUSG000000282456


Protein motifs (from Interpro)
Interpro ID Name
 IPR000409  BEACH domain
 IPR001680  WD40 repeat
 IPR011993  PH-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR016024  Armadillo-type fold
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR023362  PH-BEACH domain
 IPR030464  Lysosomal-trafficking regulator
 IPR036322  WD40-repeat-containing domain superfamily
 IPR036372  BEACH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007040 lysosome organization IEA
 biological_processGO:0032510 endosome to lysosome transport via multivesicular body sorting pathway IEA
 biological_processGO:0042267 natural killer cell mediated cytotoxicity IEA
 biological_processGO:0043473 pigmentation IEA
 cellular_componentGO:0015630 microtubule cytoskeleton IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0000322 increased granulocyte number "greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Lystbg-slt/Lystbg-slt
Genetic Background: YZ57/Ch

Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad
Genetic Background: involves: CT/Ch * YZ57/Ch

Allelic Composition: Hps6ru/Hps6ru,Lystbg-slt/Lystbg-slt
Genetic Background: involves: YZ57/Ch

Allelic Composition: Lystbg-slt/Lystbg-slt,Oca2p/Oca2p
Genetic Background: involves: CT/Ch * YZ57/Ch

Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad,Oca2p/Oca2p,Tyrp1b/Tyrp1b
Genetic Background: involves: CT/Ch * YZ57/Ch

Allelic Composition: Lystbg-14J/Lystbg-14J
Genetic Background: C3Fe;B6-Lystbg-14J

Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

Allelic Composition: Lystbg-Btlr/Lystbg-Btlr
Genetic Background: C57BL/6J-Lystbg-Btlr

Allelic Composition: Lystbg-2Btlr/Lystbg-2Btlr
Genetic Background: C57BL/6J-Lystbg-2Btlr

Allelic Composition: Lystbg-10J/Lystbg-10J
Genetic Background: involves: C57BL/6J * LT/Sv * MA/My * TF/Le

Allelic Composition: Lystbg-Lac/Lystbg-Lac
Genetic Background: CBA/CaLac-Lystbg-Lac

Allelic Composition: Lystbg-3Btlr/Lystbg-3Btlr
Genetic Background: C57BL/6J-Lystbg-3Btlr

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

Allelic Composition: A/?,Lystbg/Lystbg,Tyrp1+/?
Genetic Background: Not Specified

Allelic Composition: a/a,Hps6ru-5J/Hps6ru-5J,Lystbg/Lystbg
Genetic Background: involves: C3H/Rl * C57BL/6J

Allelic Composition: Lystbg-11J/Lystbg-11J
Genetic Background: involves: C57BL/6J

Allelic Composition: Lystbg-8J/Lystbg-8J
Genetic Background: involves: DBA/2J

Allelic Composition: Lystbg-4Btlr/Lystbg-4Btlr
Genetic Background: C57BL/6J-Lystbg-4Btlr

Allelic Composition: Lystbg-7Btlr/Lystbg-7Btlr
Genetic Background: C57BL/6J-Lystbg-7Btlr

Allelic Composition: Lystbg-8Btlr/Lystbg-8Btlr
Genetic Background: C57BL/6J-Lystbg-8Btlr

Allelic Composition: Lystbg-9Btlr/Lystbg-9Btlr
Genetic Background: C57BL/6J-Lystbg-9Btlr

Allelic Composition: Lystbg-10Btlr/Lystbg-10Btlr
Genetic Background: C57BL/6J-Lystbg-10Btlr

 MP:0000372 irregular coat pigmentation "uneven coloration of the hair" [J:65030]
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Allelic Composition: A/?,Lystbg/Lystbg,Tyrp1+/?
Genetic Background: Not Specified

 MP:0000394 absent melanin granules in hair follicle "missing pigment polymers in the hair follicles" [J:18378]
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Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0000423 delayed hair regrowth "slow initiation and asynchrony of the hair growth cycle (anagen) after catagen phase " [J:61509]
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Allelic Composition: Lystbg-slt/Lystbg-slt
Genetic Background: YZ57/Ch

Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad,Oca2p/Oca2p,Tyrp1b/Tyrp1b
Genetic Background: involves: CT/Ch * YZ57/Ch

 MP:0000427 abnormal hair cycle "aberrant growth or asynchronous timing of the hair growth " [J:65302]
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Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad,Oca2p/Oca2p,Tyrp1b/Tyrp1b
Genetic Background: involves: CT/Ch * YZ57/Ch

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0000858 altered metastatic potential 
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0000880 decreased Purkinje cell number "fewer than normal neuronal cells that are located in the interface of the molecular and granular layers of the cerebellar cortex" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:45302]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0000885 ectopic Purkinje cell "Purkinje cell body resides in places other than the Purkinje cell layer in the cerebellum" [MGI:tc, J:60896]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Hps1ep/Hps1ep
Genetic Background: B6.C3Fe-Hps1ep/J

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001243 abnormal dermal layer morphology "malformed or atypical condition of the dermal layer of the skin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0001324 abnormal eye pigmentation "change in the normal black pigmentation of the eye to another color, or lack of color" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg-slt/Lystbg-slt,Oca2p/Oca2p
Genetic Background: involves: CT/Ch * YZ57/Ch

Allelic Composition: Ednrbs/Ednrbs,Lystbg-slt/Lystbg-slt
Genetic Background: involves: C57BL/10Ch * Y257/Ch

Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

Allelic Composition: Lystbg-10J/Lystbg-10J
Genetic Background: involves: C57BL/6J * LT/Sv * MA/My * TF/Le

Allelic Composition: Lystbg-Lac/Lystbg-Lac
Genetic Background: CBA/CaLac-Lystbg-Lac

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

Allelic Composition: A/?,Lystbg/Lystbg,Tyrp1+/?
Genetic Background: Not Specified

Allelic Composition: a/a,Hps6ru-5J/Hps6ru-5J,Lystbg/Lystbg
Genetic Background: involves: C3H/Rl * C57BL/6J

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0001522 impaired swimming "reduced ability or inability to swim" [J:45446, J:39081]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0001525 impaired balance "reduced ability of an animal to maintain equilibrium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:64962, J:17123]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0001760 abnormal urine enzyme level "any change in the level of excretion of enzymes in the urine" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: PrkcbM3Btlr/Prkcb+
Genetic Background: C57BL/6J-PrkcbM3Btlr

Allelic Composition: Lystbg-5Btlr/Lyst+
Genetic Background: C57BL/6J-Lystbg-5Btlr

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0001862 interstitial pneumonia "disorder of the lower respiratory tract, primarily affecting the alveolar wall, but may also involve the small airways and blood vessels of the lung parencyma; this is usually inflammatory in nature" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Foxq1sa/Foxq1sa,Lystbg/Lystbg
Genetic Background: involves: 101/Rl * C3H/Rl * C57BL10/Rl

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
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Allelic Composition: Hps1ep/Hps1ep
Genetic Background: B6.C3Fe-Hps1ep/J

 MP:0002021 increased incidence of induced tumors "higher than normal frequency of tumor incidence induced by a carcinogen or mutagen" [J:44427]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002060 abnormal skin morphology "malformation or atypical structure of the membranous protective covering of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:56777]
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Allelic Composition: Bmp2tm1Jfm/Bmp2tm1Jfm,Nkx2-5tm1(cre)Rjs/Nkx2-5+
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002075 abnormal coat color "irregular or unusual pigmentation pattern of the hair in relation to control animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Hps6ru-5J/Hps6ru-5J,Lystbg/Lystbg
Genetic Background: involves: C3H/Rl * C57BL/6J

Allelic Composition: Lystbg-11J/Lystbg-11J
Genetic Background: involves: C57BL/6J

Allelic Composition: Lystbg-8J/Lystbg-8J
Genetic Background: involves: DBA/2J

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: MitfMi-ws/MitfMi-ws
Genetic Background: involves: C57BL/6

Allelic Composition: Lystbg-10J/Lystbg-10J
Genetic Background: involves: C57BL/6J * LT/Sv * MA/My * TF/Le

 MP:0002166 altered tumor susceptibility/resistance "greater than or less than the average number of tumors, usually a specific type, arising in a given strain when compared to controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002339 abnormal lymph node morphology "anomalous structure, size, or celluarity of the oval or bean shaped bodies located along the lymphatic system" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rag2tm1Fwa/Rag2tm1Fwa,Tg(Tcra51-11.5,Tcrb51-11.5)AR206Ayr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * C57BL/6NTac * DBA/2

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0002406 increased susceptibility to infection "greater likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Lystbg/Lystbg,Prkdcscid/Prkdcscid
Genetic Background: Not Specified

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-Btlr/Lystbg-Btlr
Genetic Background: C57BL/6J-Lystbg-Btlr

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-Btlr/Lystbg-Btlr
Genetic Background: C57BL/6J-Lystbg-Btlr

Allelic Composition: Lystbg-2Btlr/Lystbg-2Btlr
Genetic Background: C57BL/6J-Lystbg-2Btlr

Allelic Composition: Lystbg-6Btlr/Lystbg-6Btlr
Genetic Background: C57BL/6J-Lystbg-6Btlr

 MP:0002441 abnormal granulocyte morphology/development "anomalous structure, differentiation, or number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Grid2Lc/Grid2+
Genetic Background: B6CBACa Aw-J/A-Grid2Lc/J

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0002460 decreased circulating immunoglobulin concentration "less than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0002619 abnormal lymphocyte morphology/development "anomalous structure, differentiation, or number of the white blood cells formed in the body s lymphoid tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002761 abnormal hippocampal mossy fiber morphology "absence or misprojection of axons of neuronal cells in the dentate gyrus" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:4978]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002762 ectopic granule cells "granule cell body resides in a place other than the external or internal granule layer of the cerebellum" [J:4978]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002763 ectopic Bergmann glia cells "mispositioned astrocyte-type glia cell associated with Purkinje cells in the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:4978]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002877 abnormal melanocyte morphology "malformation of the cells that produce pigment " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0003172 abnormal lysosome physiology "ability of lysosomes to produce enzymes necessary for digestion of exogenous material is impaired" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg/Lystbg
Genetic Background: B6.C3Rl-Lystbg/J

 MP:0003173 decreased lysosomal enzyme secretion "production of glycoprotein hydrolytic enzymes is decreased compared to normal" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0003727 abnormal retinal layer morphology "malformation in any of the layers that make up the retina" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004221 abnormal iridocorneal angle "any structural abnormality of the acute angle occurring between the iris and the cornea at the periphery of the anterior chamber of the eye" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0004381 abnormal hair follicle melanocyte morphology "any structural anomaly of the cells that produce pigment in the hair follicles" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0004725 decreased platelet serotonin level "reduced concentration of serotonin in the platelets; this biochemical messenger and regulator, found in the CNS, gastrointestinal tract, and produced by platelets mediates neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0004844 abnormal vestibuloocular reflex "any anomaly in the nystagmus or deviation of the eyes in response to stimulation of the vestibular system in which impulses are conveyed from the semicircular canals and the otolithic membrane to the oculomotor nerve; this stimulation may occur by angular acceleration or deceleration or by irrigation of the ear with hot or cold water; normally, this reflex functions to maintain a stable retinal image during head rotation by generating appropriate compensatory eye movements" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hps1ep/Hps1ep
Genetic Background: B6.C3Fe-Hps1ep/J

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lystbg/Lystbg
Genetic Background: B6.C3Rl-Lystbg/J

Allelic Composition: Lystbg-Lac/Lystbg-Lac
Genetic Background: CBA/CaLac-Lystbg-Lac

 MP:0005059 lysosomal protein accumulation "buildup of protein in the lysosome" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005060 accumulation of giant lysosomes in kidney/renal tubule cells "buildup of contents in lysosomes in cells of the kidney tubules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5590]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005061 abnormal eosinophil morphology "structural anomaly of the granular leukocytes having a two-lobed nucleus and cytoplasm containing coarse, round granules that are uniform in size and stainable by eosin" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005070 defective NK cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:6213]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005071 enlarged melanin granules in hair follicle "increased size of the pigment particles in the hair follicle" [J:5078]
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Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0005075 abnormal melanosome morphology "anomalous structure of these tissue-specific cytoplasmic organelles within which melanin pigments are synthesized and stored" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

Allelic Composition: a/a,Lystbg/Lystbg,Tyrc/Tyrc
Genetic Background: involves: C3H/Rl * C57BL/6J

Allelic Composition: a/a,Lystbg/Lystbg,Oca2p-J/Oca2p-J
Genetic Background: involves: C3H/HeJ * C3H/Rl * C57BL/6J

Allelic Composition: a/a,Hps6ru/Hps6ru,Lystbg/Lystbg
Genetic Background: involves: C3H/Rl * C57BL/6J

 MP:0005077 abnormal melanogenesis "failure of or anomaly in the biosynthetic pathway of melanin formation in cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:5346]
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Allelic Composition: a/a,Lystbg/Lystbg,Tyrc/Tyrc
Genetic Background: involves: C3H/Rl * C57BL/6J

Allelic Composition: a/a,Hps6ru/Hps6ru,Lystbg/Lystbg
Genetic Background: involves: C3H/Rl * C57BL/6J

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0005100 abnormal choroid pigmentation "anomalous coloring of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-slt/Lystbg-slt
Genetic Background: YZ57/Ch

 MP:0005101 abnormal ciliary body pigmentation "anomalous coloring of the thickened portion of the vascular tunic, which lies between the choroid and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-slt/Lystbg-slt
Genetic Background: YZ57/Ch

 MP:0005102 abnormal iris pigmentation "anomalous coloring of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-slt/Lystbg-slt
Genetic Background: YZ57/Ch

Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-slt/Lystbg-slt
Genetic Background: YZ57/Ch

Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0005114 premature hair loss "release of fur at an earlier than expected time" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-slt/Lystbg-slt
Genetic Background: YZ57/Ch

Allelic Composition: Lystbg-slt/Lystbg-slt,Myo5ad/Myo5ad,Oca2p/Oca2p,Tyrp1b/Tyrp1b
Genetic Background: involves: CT/Ch * YZ57/Ch

 MP:0005172 lack of eye pigmentation "visual organs are devoid of coloring pigment in relation to control animals, usually resulting in a red or pink color" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
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Allelic Composition: Mertktm1Grl/Mertktm1Grl,Tyro3tm1Grl/Tyro3tm1Grl
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hps6ru/Hps6ru,Lystbg-slt/Lystbg-slt
Genetic Background: involves: YZ57/Ch

Allelic Composition: Lystbg-10J/Lystbg-10J
Genetic Background: involves: C57BL/6J * LT/Sv * MA/My * TF/Le

Allelic Composition: Lystbg-Lac/Lystbg-Lac
Genetic Background: CBA/CaLac-Lystbg-Lac

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

Allelic Composition: a/a,Hps6ru-5J/Hps6ru-5J,Lystbg/Lystbg
Genetic Background: involves: C3H/Rl * C57BL/6J

 MP:0005194 abnormal anterior uvea morphology "anomalous structure of any of the parts of the front, or ventral, portion of the vascular, pigmentary, or middle coat of the eye, including the ciliary body and the iris" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0005199 abnormal iris pigment epithelium "anomaly in the epithelial layer of the iris composed of cells containing pigment granules " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0005205 abnormal eye anterior chamber "anomaly of the space in the eye, filled with aqueous humor, and bounded anteriorly by the cornea and a small portion of the sclera and posteriorly by a small portion of the ciliary body, the iris, and part of the crystalline lens" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0005208 abnormal iris stroma morphology "structural anomaly of the lamellated connective tissue of the iris" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0005398 decreased susceptibility to fungal infection "reduced likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0005408 hypopigmentation "dilution of the pigment in the body" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Lystbg-11J/Lystbg-11J
Genetic Background: involves: C57BL/6J

Allelic Composition: Lystbg-8J/Lystbg-8J
Genetic Background: involves: DBA/2J

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0006027 impaired alveologenesis "a block or reduction in the generation of alveoli" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:85546]
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Allelic Composition: Lystbg/Lystbg
Genetic Background: B6.C3Rl-Lystbg/J

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0008020 abnormal dermal mast cell morphology "any structural anomaly in cells located in connective tissue of the dermis that contain numerous basophilic granules and release substances such as heparin and histamine in response to injury or inflammation" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-grey/Lystbg-grey
Genetic Background: C57BL/6-Lystbg-grey

 MP:0008041 absent NK T cells "absence of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Lystbg-Lac/Lystbg-Lac
Genetic Background: CBA/CaLac-Lystbg-Lac

 MP:0008044 increased NK cell number "greater number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009273 abnormal hair shaft melanin granule shape "the form of pigment polymers in the hair shaft differs compared to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009379 abnormal foot pigmentation "anomaly in the coloration of the foot" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Lystbg-Btlr/Lystbg-Btlr
Genetic Background: C57BL/6J-Lystbg-Btlr

 MP:0009434 paraparesis "a weakness affecting lower limbs" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: C3.Cg-Lystbg-2J/J

 MP:0009448 decreased platelet ATP level "reduced concentration of the major energy source adenosine triphosphate produced by dense bodies located in platelets" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0009557 decreased platelet ADP level "reduced concentration of the major energy source adenosine diphosphate produced by dense bodies located in platelets" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
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Allelic Composition: Lystbg-J/Lystbg-J
Genetic Background: C57BL/6J-Lystbg-J/J

 MP:0009746 enhanced behavioral response to xenobiotic "increased sensitivity to a foreign compound capable of inducing the appearance of behavioral response, such as consumption preference, induced hyperactivity or stereotypic behavior, or reduced dosage threshold for the appearance of the behavioral response" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010011 ectopic hippocampus pyramidal cells "the hippocampus pyramidal cell body resides in places other than the pyramidal cell layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Lysttm1b(EUCOMM)Wtsi/Lysttm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Lysttm1b(EUCOMM)Wtsi/Tcp

 MP:0010192 abnormal retinal melanin granule morphology "any structural anomaly of the pigment particles in the retina" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
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Allelic Composition: a/a,Tyrp1b/Tyrp1b
Genetic Background: involves: C57BL/6J

Allelic Composition: a/a,Lystbg/Lystbg,Tyrc/Tyrc
Genetic Background: involves: C3H/Rl * C57BL/6J

Allelic Composition: a/a,Hps6ru/Hps6ru,Lystbg/Lystbg
Genetic Background: involves: C3H/Rl * C57BL/6J

Allelic Composition: a/a,Lystbg/Lystbg,Tyrp1b/Tyrp1b
Genetic Background: involves: C3H/Rl * C57BL/6J

 MP:0010193 abnormal choroid melanin granule morphology "any structural anomaly of the pigment particles in the choroid" [ISBN-13:978-1-4051-2034-0 "The Pigmentary System, Second Edition"]
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Allelic Composition: a/a,Tyrp1b/Tyrp1b
Genetic Background: involves: C57BL/6J

Allelic Composition: a/a,Lystbg/Lystbg,Tyrc/Tyrc
Genetic Background: involves: C3H/Rl * C57BL/6J

Allelic Composition: a/a,Lystbg/Lystbg,Oca2p-J/Oca2p-J
Genetic Background: involves: C3H/HeJ * C3H/Rl * C57BL/6J

Allelic Composition: a/a,Lystbg/Lystbg,Tyrp1b/Tyrp1b
Genetic Background: involves: C3H/Rl * C57BL/6J

 MP:0010766 abnormal NK cell physiology "any functional anomaly of a lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors, and also regulate immune responses via cytokine release and direct contact with other cells" [GOC:add, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15771571]
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Allelic Composition: Lystbg/Lystbg
Genetic Background: B6.C3Rl-Lystbg/J

Allelic Composition: Lystbg-Btlr/Lystbg-Btlr
Genetic Background: C57BL/6J-Lystbg-Btlr

Allelic Composition: Lystbg-2Btlr/Lystbg-2Btlr
Genetic Background: C57BL/6J-Lystbg-2Btlr

 MP:0010815 enlarged alveolar lamellar bodies "increased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0010922 alveolitis "inflammation of the small sac-like dilations of the distal airspace of the lung; acute pulmonary alveolitis involves exudate into the pulmonary alveoli and impaired gas exchange" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Ntrk2tm1Kln/Ntrk2tm1Kln,Ntrk3tm1Kln/Ntrk3tm1Kln
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011277 decreased tail pigmentation "visually detectable dilution of pigment present on the tail surface" [MGI:csmith]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

Allelic Composition: Lystbg-Btlr/Lystbg-Btlr
Genetic Background: C57BL/6J-Lystbg-Btlr

Allelic Composition: Lystbg-10J/Lystbg-10J
Genetic Background: involves: C57BL/6J * LT/Sv * MA/My * TF/Le

Allelic Composition: Lystbg-Lac/Lystbg-Lac
Genetic Background: CBA/CaLac-Lystbg-Lac

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

Allelic Composition: A/?,Lystbg/Lystbg,Tyrp1+/?
Genetic Background: Not Specified

 MP:0011279 decreased ear pigmentation "visually detectable dilution of pigment present in the outer ear" [MGI:csmith]
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Allelic Composition: Lystbg-16J/Lystbg-16J
Genetic Background: B6.129S7-Rag1tm1Mom/J

Allelic Composition: Lystbg-Btlr/Lystbg-Btlr
Genetic Background: C57BL/6J-Lystbg-Btlr

Allelic Composition: Lystbg-10J/Lystbg-10J
Genetic Background: involves: C57BL/6J * LT/Sv * MA/My * TF/Le

Allelic Composition: Lystbg-Lac/Lystbg-Lac
Genetic Background: CBA/CaLac-Lystbg-Lac

Allelic Composition: Lystbg-2J/Lystbg-2J
Genetic Background: Not Specified

Allelic Composition: A/?,Lystbg/Lystbg,Tyrp1+/?
Genetic Background: Not Specified

 MP:0012431 increased lymphoma incidence "greater than the expected number of neoplasms characterized by a proliferation of malignant lymphocytes in lymphoid tissue in a specific population in a given time period" [http://orcid.org/0000-0001-5208-3432, MGI:csmith]
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Allelic Composition: Golga3Tg(06MGMT)T604Kccri/Golga3Tg(06MGMT)T604Kccri
Genetic Background: involves: C3H * C57BL/6

 MP:0014130 thymus cysts "presence of fluid-filled spaces lined by epithelium within the thymus; thymic cysts are rare mediastinal lesions and are thought to result from the congenital persistence of thymopharyngeal tracts and acquired, progressive cystic degeneration of thymic (Hassall) corpuscles and epithelial reticulum of the thymus; congenital cysts are unilocular, whereas acquired cysts are usually multilocular and result as a consequence of inflammatory processes" [http://www.pedsradiology.com/historyanswer.aspx?qid=408&fid=1, PMID:23050117]
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Allelic Composition: Lystbg-J/Lystbg-J,Prkdcscid/Prkdcscid
Genetic Background: B6.Cg-Lystbg-J Prkdcscid/Sz

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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