ENSMUSG00000028179


Mus musculus

Features
Gene ID: ENSMUSG00000028179
  
Biological name :Cth
  
Synonyms : Cth / Cystathionine gamma-lyase / Q8VCN5
  
Possible biological names infered from orthology : P32929
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H4
Gene start: 157894248
Gene end: 157925077
  
Corresponding Affymetrix probe sets: 10503023 (MoGene1.0st)   1426243_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113672
NCBI entrez gene - 107869     See in Manteia.
MGI - MGI:1339968
RefSeq - NM_145953
RefSeq - XM_006500815
RefSeq Peptide - NP_666065
swissprot - Q8VCN5
Ensembl - ENSMUSG00000028179
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cthENSDARG00000074301Danio rerio
 cthlENSDARG00000032206Danio rerio
 CTHENSGALG00000011331Gallus gallus
 CTHENSG00000116761Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000277  Cys/Met metabolism, pyridoxal phosphate-dependent enzyme
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008652 cellular amino acid biosynthetic process IEA
 biological_processGO:0018272 protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine IEA
 biological_processGO:0019343 cysteine biosynthetic process via cystathionine IEA
 biological_processGO:0019344 cysteine biosynthetic process ISO
 biological_processGO:0019346 transsulfuration IEA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0044524 protein sulfhydration IMP
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0070814 hydrogen sulfide biosynthetic process IEA
 biological_processGO:0071266 "de novo" L-methionine biosynthetic process IBA
 biological_processGO:1904831 positive regulation of aortic smooth muscle cell differentiation IEA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 biological_processGO:2001234 negative regulation of apoptotic signaling pathway IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003962 cystathionine gamma-synthase activity IBA
 molecular_functionGO:0004123 cystathionine gamma-lyase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IBA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0044540 L-cystine L-cysteine-lyase (deaminating) ISO
 molecular_functionGO:0080146 L-cysteine desulfhydrase activity IEA
 molecular_functionGO:0098600 selenomethionine gamma-lyase activity TAS


Pathways (from Reactome)
Pathway description
Degradation of cysteine and homocysteine
Cysteine formation from homocysteine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mbd3l2tm1Gpp/Mbd3l2tm1Gpp
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cthtm1Liwu/Cth+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

 MP:0000753 paralysis "loss of power of voluntary movement in a muscle through injury or disease of its nerve supply" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nr3c1tm2Gsc/Nr3c1tm2Gsc,Stat5btm1Mam/Stat5btm1Mam,Tg(Alb1-cre)7Gsc/0
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * FVB/N

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0004065 susceptibility to induced muscular atrophy "greater than expected wasting of muscle tissue after experimental manipulation (starvation, neurectomy, immobilization, etc)" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cecr2tm2b(EUCOMM)Hmgu/Cecr2+
Genetic Background: C57BL/6N-Cecr2tm2b(EUCOMM)Hmgu/Tcp

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Mbd3l2tm1Gpp/Mbd3l2tm1Gpp
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cthtm1Liwu/Cth+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

Allelic Composition: Cthtm1Iish/Cth+
Genetic Background: B6.129-Cthtm1Iish

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0005571 decreased lactate dehydrogenase level "less than the normal concentration of this enzyme, which catalyzes the interconversion of lactate and pyruvate" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0005591 decreased vasodilation "less than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbd3l2tm1Gpp/Mbd3l2tm1Gpp
Genetic Background: involves: 129S1/Sv

 MP:0006076 abnormal circulating homocysteine level "aberrant concentration in the blood of this amino acid" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Mbd3l2tm1Gpp/Mbd3l2tm1Gpp
Genetic Background: involves: 129S1/Sv

Allelic Composition: Cthtm1Liwu/Cth+
Genetic Background: involves: 129S/SvEvBrd * C57BL/6J

Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0008412 increased cellular sensitivity to oxidative stress "greater incidence of cell death or enhanced production of reactive oxygen species after exposure to a variety of stress conditions including ionizing radiation, exposure to xenobiotics, inflammation, and phagocytosis" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbd3l2tm1Gpp/Mbd3l2tm1Gpp
Genetic Background: involves: 129S1/Sv

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbd3l2tm1Gpp/Mbd3l2tm1Gpp
Genetic Background: involves: 129S1/Sv

 MP:0008943 increased sensitivity to induced cell death "decrease in the exposure level to an agent that is required to induce cessation of function at the cellular level" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0009402 decreased skeletal muscle fiber diameter "decreased width of the cross-sectional distance that extends from one lateral edge of a skeletal muscle fiber, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cthtm1Iish/Cthtm1Iish
Genetic Background: B6.129-Cthtm1Iish

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028179 Cth / Q8VCN5 / Cystathionine gamma-lyase / P32929*  / complex






 

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