ENSMUSG00000028233


Mus musculus

Features
Gene ID: ENSMUSG00000028233
  
Biological name :Tgs1
  
Synonyms : Q923W1 / Tgs1 / Trimethylguanosine synthase
  
Possible biological names infered from orthology : Q96RS0 / trimethylguanosine synthase 1
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A1
Gene start: 3574875
Gene end: 3616619
  
Corresponding Affymetrix probe sets: 10503085 (MoGene1.0st)   1421904_at (Mouse Genome 430 2.0 Array)   1421905_at (Mouse Genome 430 2.0 Array)   1439710_at (Mouse Genome 430 2.0 Array)   1446164_at (Mouse Genome 430 2.0 Array)   1450400_at (Mouse Genome 430 2.0 Array)   1450401_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054112
NCBI entrez gene - 116940     See in Manteia.
MGI - MGI:2151797
RefSeq - NM_054089
RefSeq - XM_006537558
RefSeq Peptide - NP_473430
swissprot - Q923W1
Ensembl - ENSMUSG00000028233
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 lynENSDARG00000107511Danio rerio
 TGS1ENSGALG00000015340Gallus gallus
 TGS1ENSG00000137574Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019012  RNA cap guanine-N2 methyltransferase
 IPR029063  S-adenosyl-L-methionine-dependent methyltransferase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001510 RNA methylation IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0009452 7-methylguanosine RNA capping IEA
 biological_processGO:0032259 methylation IEA
 biological_processGO:0036261 7-methylguanosine cap hypermethylation IEA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0015030 Cajal body IEA
 molecular_functionGO:0008168 methyltransferase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0071164 RNA trimethylguanosine synthase activity IEA


Pathways (from Reactome)
Pathway description
snRNP Assembly
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003694 failure to hatch from the zona pellucida "the embryo fails to break out of the thick solid transparent outer membrane that surrounds the developing ovum and embryo prior to implantation, may be seen in vivo or in cultured embryos" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004957 abnormal blastocyst morphology "any structural anomaly of the preimplantation embryo of mammals consisting of a hollow sphere of cells with an outer cell layer (trophoblast) that forms the placenta, a fluid-filled cavity (blastocoele), and a cluster of cells on the interior (the inner cell mass) that forms the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011707 impaired fibroblast cell migration "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith]
Show

Allelic Composition: Lepob/Lepob,Sesn2Gt(RRJ141)Byg/Sesn2Gt(RRJ141)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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