ENSMUSG00000028318


Mus musculus

Features
Gene ID: ENSMUSG00000028318
  
Biological name :Polr1e
  
Synonyms : Polr1e / polymerase (RNA) I polypeptide E / Q8K202
  
Possible biological names infered from orthology : Q9GZS1 / RNA polymerase I subunit E
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: B1
Gene start: 45018583
Gene end: 45036565
  
Corresponding Affymetrix probe sets: 10504518 (MoGene1.0st)   1419058_at (Mouse Genome 430 2.0 Array)   1435057_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029999
Ensembl peptide - ENSMUSP00000059941
Ensembl peptide - ENSMUSP00000103444
Ensembl peptide - ENSMUSP00000121007
NCBI entrez gene - 64424     See in Manteia.
MGI - MGI:1929022
RefSeq - NM_022811
RefSeq - NM_001285800
RefSeq Peptide - NP_001272729
RefSeq Peptide - NP_073722
swissprot - Q8K202
swissprot - Q3V1B9
swissprot - G8JL51
Ensembl - ENSMUSG00000028318
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 polr1eENSDARG00000006434Danio rerio
 POLR1EENSGALG00000005395Gallus gallus
 POLR1EENSG00000137054Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009668  RNA polymerase I associated factor, A49-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000183 chromatin silencing at rDNA TAS
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006360 transcription by RNA polymerase I IEA
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005736 DNA-directed RNA polymerase I complex IDA
 molecular_functionGO:0001054 RNA polymerase I activity IBA
 molecular_functionGO:0001179 RNA polymerase I transcription factor binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003899 DNA-directed 5"-3" RNA polymerase activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Chain Elongation
RNA Polymerase I Transcription Termination


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0003345 decreased number of ribs "fewer than normal numbers of the pairs of bony structures that make up the body wall" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pitpnm1tm1a(EUCOMM)Wtsi/Pitpnm1tm1a(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Pitpnm1tm1a(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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