ENSMUSG00000028411


Mus musculus

Features
Gene ID: ENSMUSG00000028411
  
Biological name :Aptx
  
Synonyms : Aprataxin / Aptx / Q7TQC5
  
Possible biological names infered from orthology : Q7Z2E3
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 40682382
Gene end: 40703194
  
Corresponding Affymetrix probe sets: 10512098 (MoGene1.0st)   1450921_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103738
Ensembl peptide - ENSMUSP00000124264
Ensembl peptide - ENSMUSP00000124769
Ensembl peptide - ENSMUSP00000030119
Ensembl peptide - ENSMUSP00000116966
NCBI entrez gene - 66408     See in Manteia.
MGI - MGI:1913658
RefSeq - XM_011250084
RefSeq - NM_001025444
RefSeq - NM_001025445
RefSeq - NM_025545
RefSeq - XM_006538167
RefSeq - XM_006538168
RefSeq - XM_006538169
RefSeq - XM_006538170
RefSeq - XM_006538171
RefSeq - XM_006538166
RefSeq Peptide - NP_001020615
RefSeq Peptide - NP_001020616
RefSeq Peptide - NP_079821
swissprot - Q7TQC5
swissprot - E0CXB7
Ensembl - ENSMUSG00000028411
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aptxENSDARG00000027143Danio rerio
 APTXENSGALG00000001954Gallus gallus
 APTXENSG00000137074Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pnkp / polynucleotide kinase 3- phosphatase / Q96T60*ENSMUSG0000000296323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR008984  SMAD/FHA domain superfamily
 IPR011146  HIT-like domain
 IPR013087  Zinc finger C2H2-type
 IPR019808  Histidine triad, conserved site
 IPR026963  Aprataxin
 IPR032566  Aprataxin, C2HE/C2H2/C2HC zinc finger
 IPR036265  HIT-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000012 single strand break repair IEA
 biological_processGO:0006266 DNA ligation IDA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006302 double-strand break repair ISO
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0016311 dephosphorylation IEA
 biological_processGO:0031647 regulation of protein stability IEA
 biological_processGO:0042542 response to hydrogen peroxide IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0098506 polynucleotide 3" dephosphorylation IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003684 damaged DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008967 phosphoglycolate phosphatase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0033699 DNA 5"-adenosine monophosphate hydrolase activity IMP
 molecular_functionGO:0046403 polynucleotide 3"-phosphatase activity ISO
 molecular_functionGO:0046872 metal ion binding TAS
 molecular_functionGO:0047485 protein N-terminus binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA
 molecular_functionGO:0120108 DNA-3"-diphospho-5"-guanosine diphosphatase IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0008058 abnormal DNA repair "any anomaly in the process of restoring DNA after damage or replication error" [GO:0006281]
Show

Allelic Composition: Tyrp1B-lt/Tyrp1B-lt
Genetic Background: Not Specified

 MP:0010947 abnormal single-strand DNA break repair "anomaly in the process of repair of single strand breaks in DNA; repair of such breaks is mediated by the same enzyme systems as are used in base excision repair" [GO:0000012]
Show

Allelic Composition: Tyrp1B-lt/Tyrp1B-lt
Genetic Background: Not Specified

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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