ENSMUSG00000028427


Mus musculus

Features
Gene ID: ENSMUSG00000028427
  
Biological name :Aqp7
  
Synonyms : Aqp7 / Aquaporin-7 / O54794
  
Possible biological names infered from orthology : AL845331.2 / O14520
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 41033074
Gene end: 41048139
  
Corresponding Affymetrix probe sets: 10512145 (MoGene1.0st)   1418848_at (Mouse Genome 430 2.0 Array)   1418849_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030136
Ensembl peptide - ENSMUSP00000093007
NCBI entrez gene - 11832     See in Manteia.
MGI - MGI:1314647
RefSeq - XM_006537563
RefSeq - NM_007473
RefSeq - XM_006537559
RefSeq - XM_006537560
RefSeq - XM_006537562
RefSeq Peptide - NP_031499
swissprot - O54794
swissprot - Q5DX24
Ensembl - ENSMUSG00000028427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aqp7ENSDARG00000026787Danio rerio
 ENSGALG00000018534Gallus gallus
 AL845331.2ENSG00000259916Homo sapiens
 AQP7ENSG00000165269Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aqp3 / Q8R2N1 / Aquaporin-3 / Q92482* / aquaporin 3 (Gill blood group)*ENSMUSG0000002843541
Aqp9 / Q9JJJ3 / Aquaporin-9 / O43315*ENSMUSG0000003220438


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR015686  Aquaporin 7
 IPR023271  Aquaporin-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006833 water transport TAS
 biological_processGO:0015793 glycerol transport IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070295 renal water absorption IGI
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0046930 pore complex IEA
 molecular_functionGO:0015250 water channel activity TAS
 molecular_functionGO:0015254 glycerol channel activity ISO
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0015288 porin activity IEA


Pathways (from Reactome)
Pathway description
Transport of glycerol from adipocytes to the liver by Aquaporins
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000189 hypoglycemia "low levels of plasma glucose in the circulating blood; this generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Chuktm1Ver/Chuktm1Ver
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp7tm1.1Suc/Aqp7tm1.1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0003058 increased insulin secretion "greater than normal release of this hormone secreted by beta cells of the pancreas, that promotes glucose utilization, protein synthesis, and the formation and storage of neutral lipids " [MeSH:National Library of Medicine - Medical Subject Headings, 2003, RGD:Rat Genome Database submission]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003440 decreased glycerol level "lower than normal concentration of glycerol" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0003441 increased glycerol level "higher than normal concentration of glycerol" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0003442 decreased circulating glycerol level "lower than normal concentration of glycerol in the blood" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: MitfMi-b/Mitf+
Genetic Background: involves: 101/Rl * C3H/Rl

 MP:0003927 enhanced cellular glucose import "improved ability of a cell to take in glucose from the environment" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: C1galt1ptl1/C1galt1ptl1,Rag1tm1Bal/Rag1tm1Bal
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005670 abnormal white fat physiology "functional aberration in the connective tissue consisting of fat-storing cells and arranged in lobular groups or along minor blood vessels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0006094 adipocyte hypertrophy "increase in the size of fat cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:90802]
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Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0009172 small pancreatic islets "decrease in the size of the clusters of hormone-producing cells that are scattered throughout the pancreas" [MA:0000127, MESH:A03.734.414]
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Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009177 decreased pancreatic alpha cell number "reduction in the number of the cells of the pancreas that secrete glucagon" [MESH:A03.734.414.065]
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Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009186 decreased PP cell number "reduced number of the polygonal pancreatic polypeptide producing cells in the islets of Langerhans in the pancreas" [CL:0000696, MESH:A03.734.414.587]
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Allelic Composition: Aqp7tm1Chan/Aqp7tm1Chan
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Stk11tm1Keis/Stk11tm1Keis,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: FVB

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Blnktm1Dkit/Blnktm1Dkit,Prkcdtm1Kin/Prkcdtm1Kin
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028427 Aqp7 / O54794 / Aquaporin-7 / O14520* / AL845331.2*  / complex






 

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