ENSMUSG00000028435


Mus musculus

Features
Gene ID: ENSMUSG00000028435
  
Biological name :Aqp3
  
Synonyms : Aqp3 / Aquaporin-3 / Q8R2N1
  
Possible biological names infered from orthology : aquaporin 3 (Gill blood group) / Q92482
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: A5
Gene start: 41092722
Gene end: 41098183
  
Corresponding Affymetrix probe sets: 10512156 (MoGene1.0st)   1422007_at (Mouse Genome 430 2.0 Array)   1422008_a_at (Mouse Genome 430 2.0 Array)   1447727_at (Mouse Genome 430 2.0 Array)   1450460_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000055110
NCBI entrez gene - 11828     See in Manteia.
MGI - MGI:1333777
RefSeq - NM_016689
RefSeq Peptide - NP_057898
swissprot - Q8R2N1
Ensembl - ENSMUSG00000028435
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 aqp3aENSDARG00000003808Danio rerio
 aqp3bENSDARG00000069518Danio rerio
 AQP3ENSGALG00000002452Gallus gallus
 AQP3ENSG00000165272Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Aqp9 / Q9JJJ3 / Aquaporin-9 / O43315*ENSMUSG0000003220443
Aqp7 / O54794 / Aquaporin-7 / O14520* / AL845331.2*ENSMUSG0000002842742


Protein motifs (from Interpro)
Interpro ID Name
 IPR000425  Major intrinsic protein
 IPR022357  Major intrinsic protein, conserved site
 IPR023271  Aquaporin-like
 IPR023275  Aquaporin 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002684 positive regulation of immune system process IEA
 biological_processGO:0006833 water transport IDA
 biological_processGO:0015793 glycerol transport IDA
 biological_processGO:0015840 urea transport IMP
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0042476 odontogenesis IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0070295 renal water absorption IMP
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0090650 cellular response to oxygen-glucose deprivation IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 molecular_functionGO:0015250 water channel activity TAS
 molecular_functionGO:0015254 glycerol channel activity IEA
 molecular_functionGO:0015267 channel activity IEA


Pathways (from Reactome)
Pathway description
Vasopressin regulates renal water homeostasis via Aquaporins
Passive transport by Aquaporins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0000465 gastrointestinal hemorrhage "bleeding in the stomach and/or the intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0001426 polydipsia "excessive thirst that is relatively prolonged" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask,Aqp5tm1Ask/Aqp5tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0002378 abnormal gut-associated lymphoid tissue morphology "anomalous structure or development of the regional immune system located in the gut" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0002965 hyperalbuminemia "blood albumin concentration above the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0002988 decreased urine osmolarity "reduction in the concentration of ions in the urine compared to normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:83000]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Aqp3tm1Ask/Aqp3tm1Ask,Aqp4tm1Ask/Aqp4tm1Ask
Genetic Background: involves: C57BL/6J

 MP:0005553 increased circulating creatinine level "greater than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0005568 increased circulating total protein level "greater than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission]
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Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0008789 abnormal olfactory epithelium morphology "any structural anomaly in the epithelial cells that line the interior of the nose" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Aqp1tm1Ask/Aqp1tm1Ask
Genetic Background: involves: C57BL/6J * CD-1

 MP:0008997 increased blood osmolality "increase in the concentration of ions in the blood compared to the normal state" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/App+
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0010180 increased susceptibility to weight loss "greater decrease in body weight over time when compared to the average decrease in weight in response to dietary modification, fasting or caloric restriction" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * Jcl:ICR

 MP:0011443 abnormal renal water transport "any anomaly in the directed movement of water (H2O) by the kidney" [GO:0003097]
Show

Allelic Composition: Apoetm1Lmh/Apoe+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028435 Aqp3 / Q8R2N1 / Aquaporin-3 / Q92482* / aquaporin 3 (Gill blood group)*  / complex






 

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