ENSMUSG00000028556


Mus musculus

Features
Gene ID: ENSMUSG00000028556
  
Biological name :Dock7
  
Synonyms : dedicator of cytokinesis 7 / Dock7
  
Possible biological names infered from orthology : Q96N67
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C6
Gene start: 98936671
Gene end: 99120915
  
Corresponding Affymetrix probe sets: 10514590 (MoGene1.0st)   1425315_at (Mouse Genome 430 2.0 Array)   1448892_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030286
Ensembl peptide - ENSMUSP00000145985
Ensembl peptide - ENSMUSP00000145833
Ensembl peptide - ENSMUSP00000145749
Ensembl peptide - ENSMUSP00000145604
Ensembl peptide - ENSMUSP00000119103
Ensembl peptide - ENSMUSP00000117797
Ensembl peptide - ENSMUSP00000114204
Ensembl peptide - ENSMUSP00000075233
NCBI entrez gene - 67299     See in Manteia.
MGI - MGI:1914549
RefSeq - XM_006503308
RefSeq - XM_017320362
RefSeq - XM_006503317
RefSeq - XM_006503315
RefSeq - XM_006503314
RefSeq - XM_006503313
RefSeq - XM_006503311
RefSeq - XM_006503310
RefSeq - NM_001290636
RefSeq - NM_026082
RefSeq - XM_017320363
RefSeq - XM_006503309
RefSeq Peptide - NP_001277565
RefSeq Peptide - NP_080358
swissprot - E9PX48
swissprot - F6ZJ55
swissprot - A0A0U1RNK7
swissprot - A0A0U1RNY4
swissprot - A0A0U1RP53
swissprot - A0A0U1RPH6
swissprot - A2A9M4
swissprot - A2A9M5
swissprot - A2AW79
Ensembl - ENSMUSG00000028556
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock7ENSDARG00000078675Danio rerio
 ENSGALG00000041436Gallus gallus
 ENSGALG00000010967Gallus gallus
 DOCK7ENSG00000116641Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dock6 / Q8VDR9 / Dedicator of cytokinesis protein 6 / Q96HP0* / dedicator of cytokinesis 6*ENSMUSG0000003219865
Dock8 / Q8C147 / Dedicator of cytokinesis protein 8 / Q8NF50* / dedicator of cytokinesis 8*ENSMUSG0000005208556
A2AF47 / Dock11 / Dedicator of cytokinesis protein 11 / Q5JSL3* / dedicator of cytokinesis 11*ENSMUSG0000003109330
Dock10 / dedicator of cytokinesis 10 / Q96BY6*ENSMUSG0000003860828
Dock9 / dedicator of cytokinesis protein 9 isoform 5 / Q9BZ29* / dedicator of cytokinesis 9*ENSMUSG0000002555828


Protein motifs (from Interpro)
Interpro ID Name
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR021816  Dedicator of cytokinesis C/D, N-terminal
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000226 microtubule cytoskeleton organization IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0031175 neuron projection development IEA
 biological_processGO:0033138 positive regulation of peptidyl-serine phosphorylation IEA
 biological_processGO:0045200 establishment of neuroblast polarity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0090630 activation of GTPase activity IEA
 biological_processGO:1904754 positive regulation of vascular associated smooth muscle cell migration IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IEA


Pathways (from Reactome)
Pathway description
MET activates RAP1 and RAC1
NTRK2 activates RAC1
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000371 diluted coat color "a coat color that appears lighter in intensity or paler than normal" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc7a9tm1Nune/Slc7a9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0000373 belly spot "the appearance of a round area of white fur on the belly" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0000569 abnormal digit pigmentation "anomalous coloration of the fingers or toes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0001258 decreased body length "decreased crown to tail distance compared to controls" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0001360 abnormal social investigation "altered behavior of animals to approach and examine other animals" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0001783 decreased white fat amount "reduced quantity of fat-storing cells/tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002095 abnormal skin pigmentation "variation of skin color or complexion" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Snap25tm1.1Bark/Snap25tm1.1Bark
Genetic Background: B6.Cg-Snap25tm1.1Bark

 MP:0002940 variable body spotting "the appearance of patches of white fur at random on the coat" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Slc7a9tm1Nune/Slc7a9+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005175 non-pigmented tail tip "lack of color at the end of the tail " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:83500]
Show

Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0005606 increased bleeding time "greater than the normal duration of blood flow after skin puncture; indicative of platelet and capillary function" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008779 abnormal maternal behavior "any response from the mother inconsistent with ability of young to thrive" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dock7mnlt/Dock7mnlt
Genetic Background: C57BL/6J-Dock7mnlt

 MP:0009557 decreased platelet ADP level "reduced concentration of the major energy source adenosine diphosphate produced by dense bodies located in platelets" [MGI:mberry "Melissa Berry, Genetics Resources Curator"]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0014168 abnormal brown adipose tissue mass "aberrant physical bulk or volume of brown adipose tissue" [MGI:csmith]
Show

Allelic Composition: Rb1tm1Tyj/Rb1tm1Tyj,Rbl1tm1Tyj/Rbl1tm1Tyj
Genetic Background: involves: 129S2/SvPas * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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