ENSMUSG00000052085


Mus musculus

Features
Gene ID: ENSMUSG00000052085
  
Biological name :Dock8
  
Synonyms : Dedicator of cytokinesis protein 8 / Dock8 / Q8C147
  
Possible biological names infered from orthology : dedicator of cytokinesis 8 / Q8NF50
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: B
Gene start: 24999529
Gene end: 25202432
  
Corresponding Affymetrix probe sets: 10462140 (MoGene1.0st)   1431961_at (Mouse Genome 430 2.0 Array)   1433437_at (Mouse Genome 430 2.0 Array)   1439226_at (Mouse Genome 430 2.0 Array)   1449419_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000025831
NCBI entrez gene - 76088     See in Manteia.
MGI - MGI:1921396
RefSeq - XM_011247397
RefSeq - NM_028785
RefSeq - XM_006527435
RefSeq Peptide - NP_083061
swissprot - Q8C147
Ensembl - ENSMUSG00000052085
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock8ENSDARG00000055225Danio rerio
 ENSGALG00000035473Gallus gallus
 ENSGALG00000010156Gallus gallus
 DOCK8ENSG00000107099Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dock7 / dedicator of cytokinesis 7 / Q96N67*ENSMUSG0000002855657
Dock6 / Q8VDR9 / Dedicator of cytokinesis protein 6 / Q96HP0* / dedicator of cytokinesis 6*ENSMUSG0000003219852
A2AF47 / Dock11 / Dedicator of cytokinesis protein 11 / Q5JSL3* / dedicator of cytokinesis 11*ENSMUSG0000003109329
Dock9 / dedicator of cytokinesis protein 9 isoform 5 / Q9BZ29* / dedicator of cytokinesis 9*ENSMUSG0000002555829
Dock10 / dedicator of cytokinesis 10 / Q96BY6*ENSMUSG0000003860828


Protein motifs (from Interpro)
Interpro ID Name
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021816  Dedicator of cytokinesis C/D, N-terminal
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001771 immunological synapse formation IMP
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0036336 dendritic cell migration IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0061485 memory T cell proliferation IEA
 biological_processGO:0070233 negative regulation of T cell apoptotic process IMP
 biological_processGO:1903905 positive regulation of establishment of T cell polarity IMP
 biological_processGO:1990869 cellular response to chemokine IEA
 biological_processGO:2000406 positive regulation of T cell migration IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0031256 leading edge membrane IEA
 cellular_componentGO:0031258 lamellipodium membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity ISO
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000920 abnormal myelination "atypical or altered myelination in axon sheaths" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Dock8pri/Dock8pri
Genetic Background: C57BL/6JAnu-Dock8pri

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cdo1tm1Mhst/Cdo1tm1Mhst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

Allelic Composition: Dock8m1Btlr/Dock8m1Btlr
Genetic Background: C57BL/6J-Dock8m1Btlr

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J

Allelic Composition: Dock8m2Anu/Dock8m2Anu
Genetic Background: C57BL/6NCrlAnu-Dock8m2Anu

 MP:0001830 decreased activated T cell number "reduced numbers of effector T cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Rasgrp1tm1Jstn/Rasgrp1tm1Jstn
Genetic Background: involves: 129P3/J

Allelic Composition: Dock8m2Anu/Dock8m2Anu
Genetic Background: C57BL/6NCrlAnu-Dock8m2Anu

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Cdo1tm1Mhst/Cdo1tm1Mhst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0004978 decreased B-1 B cell number "reduced number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dock8pri/Dock8pri
Genetic Background: C57BL/6JAnu-Dock8pri

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Dock8pri/Dock8pri
Genetic Background: C57BL/6JAnu-Dock8pri

Allelic Composition: Dock8cpm/Dock8pri
Genetic Background: C57BL/6J-Dock8cpm/Dock8pri

Allelic Composition: Dock8m1Anu/Dock8m1Anu
Genetic Background: C57BL/6NCrlAnu-Dock8m1Anu

Allelic Composition: Dock8m2Anu/Dock8m2Anu
Genetic Background: C57BL/6NCrlAnu-Dock8m2Anu

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Cdo1tm1Mhst/Cdo1tm1Mhst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdo1tm1Mhst/Cdo1tm1Mhst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cdo1tm1Mhst/Cdo1tm1Mhst,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Dock8pri/Dock8pri
Genetic Background: C57BL/6JAnu-Dock8pri

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Dock8pri/Dock8pri
Genetic Background: C57BL/6JAnu-Dock8pri

Allelic Composition: Dock8cpm/Dock8pri
Genetic Background: C57BL/6J-Dock8cpm/Dock8pri

Allelic Composition: Dock8tm1Ysfk/Dock8tm1Ysfk
Genetic Background: B6.Cg-Dock8tm1Ysfk

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
Show

Allelic Composition: Dock8m2Anu/Dock8m2Anu
Genetic Background: C57BL/6NCrlAnu-Dock8m2Anu

 MP:0008200 decreased follicular dendritic cell number "reduced number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200]
Show

Allelic Composition: Dock8tm1Ysfk/Dock8tm1Ysfk
Genetic Background: B6.Cg-Dock8tm1Ysfk

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cyp26b1tm1Ptk/Cyp26b1tm1Ptk,Plekha5Tg(AMH-cre)1Flor/0
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Dock8pri/Dock8pri
Genetic Background: C57BL/6JAnu-Dock8pri

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
Show

Allelic Composition: Ncr1m1J/Ncr1m1J,Pepcb/Pepcb,Ptprca/Ptprca
Genetic Background: B6.SJL-Ptprca Pepcb/BoyJ

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
Show

Allelic Composition: Dock8m1Btlr/Dock8m1Btlr
Genetic Background: C57BL/6J-Dock8m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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