ENSMUSG00000028565


Mus musculus

Features
Gene ID: ENSMUSG00000028565
  
Biological name :Nfia
  
Synonyms : Nfia / Nuclear factor 1 A-type / Q02780
  
Possible biological names infered from orthology : nuclear factor I A / Q12857
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: C6
Gene start: 97772734
Gene end: 98118874
  
Corresponding Affymetrix probe sets: 10506031 (MoGene1.0st)   10506050 (MoGene1.0st)   1421162_a_at (Mouse Genome 430 2.0 Array)   1421163_a_at (Mouse Genome 430 2.0 Array)   1427733_a_at (Mouse Genome 430 2.0 Array)   1438236_at (Mouse Genome 430 2.0 Array)   1446990_at (Mouse Genome 430 2.0 Array)   1456087_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102672
Ensembl peptide - ENSMUSP00000102677
Ensembl peptide - ENSMUSP00000130032
Ensembl peptide - ENSMUSP00000122641
Ensembl peptide - ENSMUSP00000114880
Ensembl peptide - ENSMUSP00000074899
Ensembl peptide - ENSMUSP00000099856
NCBI entrez gene - 18027     See in Manteia.
MGI - MGI:108056
RefSeq - XM_006502841
RefSeq - XM_006502845
RefSeq - XM_006502844
RefSeq - XM_006502843
RefSeq - XM_006502842
RefSeq - NM_001122952
RefSeq - NM_001122953
RefSeq - NM_010905
RefSeq Peptide - NP_001116424
RefSeq Peptide - NP_001116425
RefSeq Peptide - NP_035035
swissprot - Q02780
swissprot - B1AUC0
swissprot - B1AUB6
swissprot - F7CDR2
swissprot - B1AUB8
swissprot - B1AUB9
Ensembl - ENSMUSG00000028565
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NFIAENSGALG00000010924Gallus gallus
 NFIAENSG00000162599Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfix / P70257 / Nuclear factor 1 X-type / Q14938* / nuclear factor I X*ENSMUSG0000000191169
Nfib / P97863 / nuclear factor I/B / O00712*ENSMUSG0000000857561
Nfic / P70255 / Nuclear factor 1 C-type / P08651* / nuclear factor I C*ENSMUSG0000005505354


Protein motifs (from Interpro)
Interpro ID Name
 IPR000647  CTF transcription factor/nuclear factor 1
 IPR003619  MAD homology 1, Dwarfin-type
 IPR019548  CTF transcription factor/nuclear factor 1, N-terminal
 IPR019739  CTF transcription factor/nuclear factor 1, conserved site
 IPR020604  CTF transcription factor/nuclear factor 1, DNA-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0060074 synapse maturation IMP
 biological_processGO:0072189 ureter development IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0030054 cell junction ISO
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding IDA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008134 transcription factor binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Nfiatm1Rmg/Nfia+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000520 absent kidney "missing paired organs that excrete urine" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49471]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Drd2tm1(IL2RA)Koba/Drd2+
Genetic Background: B6.129P2-Drd2tm1(IL2RA)Koba

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg
Genetic Background: B6.129P2-Nfiatm1Rmg

 MP:0000825 dilated lateral ventricles "increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000827 dilated third ventricle "enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000857 abnormal cerebellar foliation "malformation of small offshoots of the cerebellar lobules" [Principles of Neural Science:ISBN 0-8385-8034-3, J:52951]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0000889 abnormal cerebellar molecular layer "any malformation or absence of the outermost layer of the cerebral cortex that contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001891 hydroencephaly "excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg
Genetic Background: B6.129P2-Nfiatm1Rmg

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003586 ureter dilation "abnormal distention of the ureter due to accumulation of fluid" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Nfiatm1Rmg/Nfia+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nfiatm1Rmg/Nfia+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg
Genetic Background: B6.129P2-Nfiatm1Rmg

 MP:0003651 abnormal axon outgrowth "defect/abnormality in the ability of an axon to extend from a neuron cell body" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:96121]
Show

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg
Genetic Background: B6.129P2-Nfiatm1Rmg

 MP:0003672 abnormal ureter development "anomalous differentiation of the tube that conducts the urine from the renal pelvis to the bladder" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96485]
Show

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

Allelic Composition: Nfiatm1Rmg/Nfia+,Tg(Hoxb7-EGFP)33Cos/?
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0003718 maternal effect "expression of a phenotypic trait in an female animal s offspring that is dependent on the maternal genotype" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0004017 duplex kidney "a kidney that is split into two separate collecting systems; there may be a duplex ureter or a single ureter; may present unilaterally or bilaterally" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Gnetm1Mhzg/Gnetm1Mhzg
Genetic Background: involves: C57BL/6J

 MP:0008221 abnormal hippocampal commissure morphology "any structural anomaly of the triangular subcallosal plate of commissural fibers resulting from the converging of the right and left fornix bundles which exchange numerous fibers and which curve back in the contralateral fornix to end in the hippocampus of the opposite side" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg
Genetic Background: B6.129P2-Nfiatm1Rmg

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Nfiatm1Rmg/Nfiatm1Rmg
Genetic Background: B6.129P2-Nfiatm1Rmg

 MP:0011488 abnormal ureterovesical junction morphology "any structural anomaly of the valve-like structure found at the site of entry of the ureter into the urinary bladder, normally displays an oblique angulation through the detrusor to avoid reflux of urine up the ureters and the kidney" [MGI:csmith]
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Allelic Composition: Nfiatm1Rmg/Nfia+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011493 double ureter "two ureters open separately into the renal pelvis superiorly and drain separately into the urinary bladder or genital tract; if two ureteral buds arise from the Wolffian duct, a duplex kidney with complete ureteral duplication ensues" [http://emedicine.medscape.com/article/378075-overview, MGI:anna]
Show

Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

Allelic Composition: Nfiatm1Rmg/Nfia+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011495 abnormal head shape "any anomaly in the characteristic surface outline or contour of a head of an organism" [MGI:csmith]
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Allelic Composition: Ndntm2Stw/Ndn+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0012545 syringomyelia "a condition whereby a fluid-filled cyst or cavity (syrinx) develops within the spinal cord" [MGI:anna]
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Allelic Composition: Pitx2tm3.1Jfm/Pitx2tm3.1Jfm
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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