ENSMUSG00000055053


Mus musculus

Features
Gene ID: ENSMUSG00000055053
  
Biological name :Nfic
  
Synonyms : Nfic / Nuclear factor 1 C-type / P70255
  
Possible biological names infered from orthology : nuclear factor I C / P08651
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 81396186
Gene end: 81455635
  
Corresponding Affymetrix probe sets: 10371176 (MoGene1.0st)   1422565_s_at (Mouse Genome 430 2.0 Array)   1427665_a_at (Mouse Genome 430 2.0 Array)   1429148_at (Mouse Genome 430 2.0 Array)   1435527_at (Mouse Genome 430 2.0 Array)   1450661_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000152790
Ensembl peptide - ENSMUSP00000113046
Ensembl peptide - ENSMUSP00000114469
Ensembl peptide - ENSMUSP00000020461
Ensembl peptide - ENSMUSP00000077317
Ensembl peptide - ENSMUSP00000100958
NCBI entrez gene - 18029     See in Manteia.
MGI - MGI:109591
RefSeq - XM_006513335
RefSeq - NM_008688
RefSeq - NM_026756
RefSeq Peptide - NP_032714
RefSeq Peptide - NP_081032
swissprot - A0A1Y7VK55
swissprot - P70255
swissprot - F6XYU7
swissprot - Q3UHA6
Ensembl - ENSMUSG00000055053
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nficENSDARG00000043210Danio rerio
 NFICENSGALG00000041643Gallus gallus
 NFICENSG00000141905Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfia / Q02780 / Nuclear factor 1 A-type / Q12857* / nuclear factor I A*ENSMUSG0000002856562
Nfib / P97863 / nuclear factor I/B / O00712*ENSMUSG0000000857560
Nfix / P70257 / Nuclear factor 1 X-type / Q14938* / nuclear factor I X*ENSMUSG0000000191156


Protein motifs (from Interpro)
Interpro ID Name
 IPR000647  CTF transcription factor/nuclear factor 1
 IPR003619  MAD homology 1, Dwarfin-type
 IPR019548  CTF transcription factor/nuclear factor 1, N-terminal
 IPR019739  CTF transcription factor/nuclear factor 1, conserved site
 IPR020604  CTF transcription factor/nuclear factor 1, DNA-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0042475 odontogenesis of dentin-containing tooth IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000116 abnormal tooth development "anomalous formation of the teeth" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0000126 brittle teeth "fragile and likely to break teeth" [J:61509]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0001431 abnormal eating behavior "inability to consume or atypical consumption pattern" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:19212]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0002689 abnormal molar morphology "structural defect of the most posterior teeth located on either side of the jaw, and characterized by a large crown and broad chewing surface" [il:Ira Lu , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0002818 abnormal dentin morphology "defects in the hard portion of the tooth surrounding the pulp, covered by enamel on the crown and cementum on the root" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0004592 small mandible "reduced size of the lower bony framework of the mouth where the inferior teeth are held" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0004791 absent lower incisors "missing the lower pair of long pointed teeth that are the most anterior and prominent in the jaw" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0011165 abnormal tooth root development "aberrant or incomplete formation of the part of a tooth that is implanted in the gum; the root is normally located below the neck of the tooth, covered by cementum rather than enamel, and attached by the periodontal ligament to the alveolar bone" [MGI:anna]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0011166 absent molar root "absence of the part of a molar tooth that is implanted in the gum; mandibular and maxillary molars usually have two and three roots, respectively" [MGI:anna]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0030083 long upper incisors "increased length or overgrowth of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0030136 abnormal lower incisor morphology "any structural anomaly of the lower set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0030137 abnormal upper incisor morphology "any structural anomaly of the upper set of long teeth that are the most anterior and prominent in the jaw" [MGI:anna]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

 MP:0030489 abnormal molar socket morphology "any structural anomaly of any of the cavities or sockets in the alveolar process of the mandible or maxilla, in which the roots of molar teeth are held by fibers of the periodontal ligament" [MGI:anna]
Show

Allelic Composition: Guca1atm1.1Hunt/Guca1atm1.1Hunt
Genetic Background: involves: 129/Sv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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