ENSMUSG00000008575


Mus musculus

Features
Gene ID: ENSMUSG00000008575
  
Biological name :Nfib
  
Synonyms : Nfib / nuclear factor I/B / P97863
  
Possible biological names infered from orthology : O00712
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C3
Gene start: 82290173
Gene end: 82705750
  
Corresponding Affymetrix probe sets: 10514049 (MoGene1.0st)   10514054 (MoGene1.0st)   1416293_at (Mouse Genome 430 2.0 Array)   1427680_a_at (Mouse Genome 430 2.0 Array)   1434101_at (Mouse Genome 430 2.0 Array)   1434102_at (Mouse Genome 430 2.0 Array)   1438244_at (Mouse Genome 430 2.0 Array)   1438245_at (Mouse Genome 430 2.0 Array)   1448288_at (Mouse Genome 430 2.0 Array)   1454834_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102866
Ensembl peptide - ENSMUSP00000102865
Ensembl peptide - ENSMUSP00000102868
Ensembl peptide - ENSMUSP00000123169
Ensembl peptide - ENSMUSP00000102869
Ensembl peptide - ENSMUSP00000052863
Ensembl peptide - ENSMUSP00000067629
NCBI entrez gene - 18028     See in Manteia.
MGI - MGI:103188
RefSeq - XM_017320022
RefSeq - NM_001113209
RefSeq - NM_001113210
RefSeq - NM_001286127
RefSeq - NM_001286131
RefSeq - NM_008687
RefSeq - XM_006537653
RefSeq - XM_006537654
RefSeq - XM_017320021
RefSeq Peptide - NP_001106680
RefSeq Peptide - NP_001273060
RefSeq Peptide - NP_032713
RefSeq Peptide - NP_001106681
RefSeq Peptide - NP_001273056
swissprot - P97863
swissprot - A2ADI3
swissprot - Q6GSP7
swissprot - A2BG77
swissprot - A2BG76
swissprot - I7HIP8
swissprot - A2BG75
Ensembl - ENSMUSG00000008575
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NFIBENSGALG00000005441Gallus gallus
 NFIBENSG00000147862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nfia / Q02780 / Nuclear factor 1 A-type / Q12857* / nuclear factor I A*ENSMUSG0000002856554
Nfix / P70257 / Nuclear factor 1 X-type / Q14938* / nuclear factor I X*ENSMUSG0000000191149
Nfic / P70255 / Nuclear factor 1 C-type / P08651* / nuclear factor I C*ENSMUSG0000005505346


Protein motifs (from Interpro)
Interpro ID Name
 IPR000647  CTF transcription factor/nuclear factor 1
 IPR003619  MAD homology 1, Dwarfin-type
 IPR019548  CTF transcription factor/nuclear factor 1, N-terminal
 IPR019739  CTF transcription factor/nuclear factor 1, conserved site
 IPR020604  CTF transcription factor/nuclear factor 1, DNA-binding domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IBA
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 biological_processGO:0010001 glial cell differentiation IMP
 biological_processGO:0021740 principal sensory nucleus of trigeminal nerve development IMP
 biological_processGO:0021960 anterior commissure morphogenesis IMP
 biological_processGO:0030324 lung development IMP
 biological_processGO:0030900 forebrain development IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0043392 negative regulation of DNA binding ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0060486 Clara cell differentiation IMP
 biological_processGO:0060509 type I pneumocyte differentiation IMP
 biological_processGO:0060510 type II pneumocyte differentiation IMP
 biological_processGO:0060662 salivary gland cavitation IMP
 biological_processGO:0060689 cell differentiation involved in salivary gland development IMP
 biological_processGO:0061141 lung ciliated cell differentiation IMP
 biological_processGO:0071679 commissural neuron axon guidance IMP
 biological_processGO:1902894 negative regulation of pri-miRNA transcription by RNA polymerase II ISO
 biological_processGO:2000791 negative regulation of mesenchymal cell proliferation involved in lung development IMP
 biological_processGO:2000795 negative regulation of epithelial cell proliferation involved in lung morphogenesis IMP
 cellular_componentGO:0001650 fibrillar center ISO
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0044300 cerebellar mossy fiber IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISO
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IMP
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000808 abnormal hippocampus development "improper differentiation of the hippocampus" [tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000814 absent dentate gyrus "lack of the section of the hippocampus normally situated above the gyrus hippocampi and composed of three layers, the molecular, granular, and polymorphic layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:59284]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000848 abnormal pons "malformed band of nerve fibers in the brain connecting the medulla oblongata and the mesencephalon; this region conveys information about movement from the cerebral hemisphere to the cerebellum" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:1776, Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000853 absent cerebellar foliation "missing small branches of the cerebellar lobules" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3, tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nfibtm2Rmg/Nfibtm2Rmg,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Nfibtm1Hsch/Nfib+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfibtm2Rmg/Nfibtm2Rmg,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0001177 atelectasis "collapse of the lung or any portion of the lung, or decreased or absent air in the lung, resulting in loss of lung volume " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Nfibtm1Hsch/Nfib+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001302 eyelids open at birth "widely open eyes instead of closed at perinatal stage" [J:51966]
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001575 cyanosis "a dark bluish or purple skin discoloration resulting from deficient oxygenation of the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60159]
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001943 abnormal respiration "anomaly in the movement of gases into and out of the lung " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0001954 respiratory distress "physical difficulty or inability to breathe" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lcn2tm1Mrgr/Lcn2tm1Mrgr
Genetic Background: involves: 129 * C57BL/6

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd

 MP:0002196 acallosal "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002273 abnormal alveolar epithelial cell morphology "any structural anomaly of the cells lining the alveoli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0003005 abnormal hippocampal fimbria "malformations in the flattened band of efferent fibers arising from the subiculum and medial border of the hippocampus, which then thickens to form the fornix and fibers of the hippocampal commissure" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003634 abnormal glia "malformation or absence of non-neuronal cells of the nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003792 abnormal major salivary gland morphology "any structural malformations of the three largest glands of the oral cavity that secrete most of the saliva, including the parotid, submandibular, and sublingual glands " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003935 abnormal craniofacial development "anomaly in the process of forming the face and/or cranium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004882 enlarged lung "increased size of the lung compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfibtm2Rmg/Nfibtm2Rmg,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0008267 abnormal hippocampus CA3 region morphology 
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008268 absent hippocampus CA3 region 
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Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009264 failure of eyelid fusion "the upper and lower thin folds of skin and muscle that cover the exposed portion of the eye do not fuse together during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009520 decreased submandibular gland size "reduced size of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009522 submandibular gland hypoplasia "underdevelopment or reduced size of either of the large major salivary glands situated beneath the mandible, usually due to reduced cell number" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010825 abnormal lung saccule morphology "any structural anomaly of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [GO:0060430, ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfibtm1Hsch/Nfib+
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Nfibtm2Rmg/Nfibtm2Rmg,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0010826 absent lung saccules "absence of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0010827 small lung saccule "reduced size of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011032 impaired branching involved in terminal bronchiole morphogenesis 
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Nfibtm1Rmg/Nfib+
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
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Allelic Composition: Nfibtm2Rmg/Nfibtm2Rmg,Twist2tm1(cre)Dor/Twist2+
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

 MP:0011143 thick lung-associated mesenchyme "increased thickness of the mesenchymal cell layer due to delay or failure of the mesenchymal compartment to thin down during the late stages of embryonic lung development" [MGI:anna]
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Allelic Composition: Nfibtm1Hsch/Nfib+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011163 increased wet-to-dry lung weight ratio "an increase in the ratio of wet lung weight (measured immediately after lung excision) to oven-dried lung weight relative to control samples; may reflect an inability to expel remaining amniotic fluid out of the lungs during or shortly after birth, or increased fluid accumulation (pulmonary edema) and/or tissue damage after lung injury" [MGI:anna]
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Allelic Composition: Hprttm1Detl/Y
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

Allelic Composition: Nfibtm1Hsch/Nfib+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0011380 enlarged brain ventricle "increased size of one or more of the four communicating cavities within the brain that are continuous with the central canal of the spinal cord" [MGI:smb]
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Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0013541 abnormal submandibular gland development "aberrant formation or incomplete differentiation of either of the paired compound tubuloalveolar (aka tubuloacinar) major salivary glands composed of both serous and mucous secretory cells and situated beneath the mandible; in mice, submandibular gland development initiates as a thickening of the oral epithelium; around E12 an initial (single) epithelial bud on a stalk grows into a condensing neural crest-derived mesenchyme; clefts in the epithelium result in 3-5 epithelial buds at E13.5, and branching morphogenesis occurs with continued proliferation, successive rounds of cleft formation, duct elongation, and duct lumen formation, so that by E14 the gland is highly branched (multi-lobed); functional differentiation, with the appearance of proacinar cells and secretory products begins after E15 and continues to birth; acinar differentiation continues postnatally with final differentiation of the granular convoluted tubules at puberty" [MGI:Anna, PMID:17336109]
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Allelic Composition: Nfibtm1Rmg/Nfibtm1Rmg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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