Manteia

ENSMUSG00000001911

Mus musculus

Features

Gene ID:	ENSMUSG00000001911

Biological name :	Nfix

Synonyms :	Nfix / Nuclear factor 1 X-type / P70257

Possible biological names infered from orthology :	nuclear factor I X / Q14938

Species:	Mus musculus

Chr. number:	8
Strand:	-1
Band:	C2
Gene start:	84699876
Gene end:	84800344

Corresponding Affymetrix probe sets:	10580191 (MoGene1.0st) 1423493_a_at (Mouse Genome 430 2.0 Array) 1436363_a_at (Mouse Genome 430 2.0 Array) 1436364_x_at (Mouse Genome 430 2.0 Array) 1451443_at (Mouse Genome 430 2.0 Array) 1459909_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000076005 Ensembl peptide - ENSMUSP00000105384 Ensembl peptide - ENSMUSP00000105386 Ensembl peptide - ENSMUSP00000115691 Ensembl peptide - ENSMUSP00000096669 NCBI entrez gene - 18032 See in Manteia. MGI - MGI:97311 RefSeq - XM_011248326 RefSeq - XM_006530756 RefSeq - XM_006530757 RefSeq - XM_006530758 RefSeq - XM_006530759 RefSeq - XM_006530760 RefSeq - XM_006530761 RefSeq - XM_006530762 RefSeq - XM_006530763 RefSeq - NM_001081981 RefSeq - NM_001081982 RefSeq - NM_001297601 RefSeq - NM_010906 RefSeq - XM_006530755 RefSeq Peptide - NP_035036 RefSeq Peptide - NP_001075450 RefSeq Peptide - NP_001075451 RefSeq Peptide - NP_001284530 swissprot - D3YZ00 swissprot - P70257 swissprot - Q3TYK3 swissprot - E9PUH7 Ensembl - ENSMUSG00000001911

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
nfixa	ENSDARG00000043226	Danio rerio
nfixb	ENSDARG00000061836	Danio rerio
NFIX	ENSG00000008441	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Nfia / Q02780 / Nuclear factor 1 A-type / Q12857* / nuclear factor I A*	ENSMUSG00000028565	71
Nfib / P97863 / nuclear factor I/B / O00712*	ENSMUSG00000008575	56
Nfic / P70255 / Nuclear factor 1 C-type / P08651* / nuclear factor I C*	ENSMUSG00000055053	50

Protein motifs (from Interpro)

Interpro ID	Name
IPR000647	CTF transcription factor/nuclear factor 1
IPR003619	MAD homology 1, Dwarfin-type
IPR019548	CTF transcription factor/nuclear factor 1, N-terminal
IPR019739	CTF transcription factor/nuclear factor 1, conserved site
IPR020604	CTF transcription factor/nuclear factor 1, DNA-binding domain

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA
biological_process	GO:0006260	DNA replication	IEA
biological_process	GO:0006351	transcription, DNA-templated	IEA
biological_process	GO:0006355	regulation of transcription, DNA-templated	IEA
biological_process	GO:0006366	transcription by RNA polymerase II	IEA
biological_process	GO:0021549	cerebellum development	IMP
biological_process	GO:0021680	cerebellar Purkinje cell layer development	IMP
biological_process	GO:0021707	cerebellar granule cell differentiation	IMP
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO
biological_process	GO:0048708	astrocyte differentiation	IMP
cellular_component	GO:0005622	intracellular	IEA
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
molecular_function	GO:0000977	RNA polymerase II regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0001228	transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA
molecular_function	GO:0003677	DNA binding	IEA
molecular_function	GO:0003700	DNA-binding transcription factor activity	IEA

Pathways (from Reactome)

Pathway description

No match

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000060	delayed bone ossification	"late onset of the formation of bone" [J:40203]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000141	abnormal vertebral body morphology	"malformed main portion of the vertebra anterior to the vertebral canal" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55583]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000161	scoliosis	"lateral and rotational curvature of the spine" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:53770, J:66943]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000162	lordosis	"anteriorly convex curvature of the spine, "saddle back" " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:62022]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000434	megacephaly	"an abnormally large size of the head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000440	domed skull		Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000496	abnormal small intestine morphology	"structural or developmental anomalies of the intestinum tenue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000780	abnormal corpus callosum morphology	"malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N Allelic Composition: Nfix^tm1Aes/Nfix⁺ Genetic Background: involves: 129S1/Sv * C57BL/6 Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0000788	abnormal cerebral cortex morphology	"malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]	Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0000807	abnormal hippocampus morphology	"absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]	Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0000812	abnormal dentate gyrus morphology	"absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]	Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0000825	dilated lateral ventricles	"increase over the normal size of the horseshoe-shaped cavities of the cerebrum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:38857]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0000827	dilated third ventricle	"enlarged narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami; its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma; it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0001263	weight loss	"progressive reduction of body weight below normal average for age" [J:45400]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N Allelic Composition: Nfix^tm1Aes/Nfix⁺ Genetic Background: involves: 129S1/Sv * C57BL/6
MP:0001290	delayed eyelid opening	"late average time for the first postnatal eye opening" [J:17792]	Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0001393	ataxia	"inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0001513	limb grasping	"mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0001891	hydroencephaly	"excessive accumulation of cerebrospinal fluid in the brain, especially the cerebral ventricles, often leading to increased brain size and other brain trauma" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0002116	abnormal craniofacial bone morphology	"abnormal development of cranial or facial bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0002152	abnormal brain morphology	"anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002169	no phenotype detected	"normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Eomes^tm1Srnr/Eomes^tm1Srnr,Tbx21^tm1Srnr/Tbx21^tm1Srnr,Tg(Cd4-cre)1Cwi/0 Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
MP:0002176	high brain weight	"greater than average weight of the brain" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0002729	abnormal canal morphology	"any anomaly or malformation of the tubular ducts of the inner ear" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0002835	abnormal cranial suture morphology	"defects of the fibrous joint in the bones of the head" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:62161]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0003419	delayed endochondral bone ossification	"late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0003662	abnormal proliferative zone	"germinal layer of the epiphyseal plate where cells are actively dividing as well as producing extracellular matrix" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:96254]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0004173	abnormal intervertebral disk morphology	"malformation of the cartilagenous and gelatinous structure found between vertebrae" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0004174	abnormal spine curvature	"deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0004684	intervertebral disk degeneration	"retrogressive pathological change of the cartilaginous and gelatinous structure found between vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0004874	abnormal timing of postnatal eyelid opening	"anomaly in the average time for the first postnatal eye opening, or failure of eyes to ever open" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0006398	increased long bone epiphyseal plate size	"greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0008263	abnormal hippocampus CA1 region morphology		Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0008489	postnatal slow weight gain	"the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0008535	enlarged lateral ventricles	"increased size of the cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube; they are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle" [MESH:A08.186.211.276.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nfix^tm1.1Rmg/Nfix^tm1.1Rmg Genetic Background: involves: 129S4/SvJae * C57BL/6 * C57BL/6J
MP:0009346	decreased cancellous bone thickness	"thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0010873	decreased trabecular bone mass	"reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N
MP:0011084	partial lethality at weaning	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms at weaning age" [MGI:csmith]	Show Allelic Composition: Coch^tm1Stw/Coch^tm1Stw,Tmem163^{Tg(ACTB-cre)2Mrt}/? Genetic Background: involves: 129S1/Sv * FVB/N

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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