ENSMUSG00000028676


Mus musculus

Features
Gene ID: ENSMUSG00000028676
  
Biological name :Srsf10
  
Synonyms : Q9R0U0 / serine/arginine-rich splicing factor 10 / Srsf10
  
Possible biological names infered from orthology : O75494 / serine and arginine rich splicing factor 10
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D3
Gene start: 135855747
Gene end: 135869908
  
Corresponding Affymetrix probe sets: 10407993 (MoGene1.0st)   10509113 (MoGene1.0st)   1418526_at (Mouse Genome 430 2.0 Array)   1418527_a_at (Mouse Genome 430 2.0 Array)   1423982_at (Mouse Genome 430 2.0 Array)   1449121_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000095455
Ensembl peptide - ENSMUSP00000099603
Ensembl peptide - ENSMUSP00000101479
Ensembl peptide - ENSMUSP00000114564
NCBI entrez gene - 14105     See in Manteia.
MGI - MGI:1333805
RefSeq - XM_011250188
RefSeq - NM_001080387
RefSeq - NM_001284195
RefSeq - NM_001284196
RefSeq - NM_010178
RefSeq Peptide - NP_001271125
RefSeq Peptide - NP_034308
RefSeq Peptide - NP_001073856
RefSeq Peptide - NP_001271124
swissprot - Q3TFP0
swissprot - Q3UA07
swissprot - Q9R0U0
Ensembl - ENSMUSG00000028676
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srsf10bENSDARG00000086411Danio rerio
 SRSF10ENSGALG00000004133Gallus gallus
 O75494ENSG00000188529Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srsf2 / Q62093 / Serine/arginine-rich splicing factor 2 / Q01130* / serine and arginine rich splicing factor 2*ENSMUSG0000003412034
Q8C8K3 / Srsf12 / Serine/arginine-rich splicing factor 12 / Q8WXF0* / serine and arginine rich splicing factor 12*ENSMUSG0000005467925
4930595M18Rik / RIKEN cDNA 4930595M18 geneENSMUSG0000006067323


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR034476  Serine/arginine-rich splicing factor 10
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000375 RNA splicing, via transesterification reactions IDA
 biological_processGO:0000398 mRNA splicing, via spliceosome ISO
 biological_processGO:0006355 regulation of transcription, DNA-templated NAS
 biological_processGO:0006376 mRNA splice site selection ISO
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006406 mRNA export from nucleus NAS
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0016482 cytosolic transport IDA
 biological_processGO:0043484 regulation of RNA splicing IEA
 biological_processGO:0048024 regulation of mRNA splicing, via spliceosome ISO
 biological_processGO:0048025 negative regulation of mRNA splicing, via spliceosome IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0016607 nuclear speck ISO
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0051082 unfolded protein binding NAS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0003103 liver degeneration "deterioration of the liver due to injury or disease, often accompanied by loss of function" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91653]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0004062 dilated right atrium "an expansion in the volume of the right upper chamber of the heart" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0004201 fetal growth retardation "slow or limited development during the fetal period (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0005329 abnormal cardiac muscle morphology "anomalous structure of the involuntary muscle comprising the myocardium " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0010403 atrial septal defect "abnormal communications between the two upper chambers of the heart, including such defects in any or all of the ostium primum, ostium secundum, sinus venosus, and coronary sinus regions" [MESH:C14.240.400.560.375]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0010413 complete atrioventricular septal defect "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

 MP:0011109 partial lethality throughout fetal growth and development "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Lama2dy-8J/Lama2dy-8J
Genetic Background: C57BL/6J-Lama2dy-8J/GrsrJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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