ENSMUSG00000034120


Mus musculus

Features
Gene ID: ENSMUSG00000034120
  
Biological name :Srsf2
  
Synonyms : Q62093 / Serine/arginine-rich splicing factor 2 / Srsf2
  
Possible biological names infered from orthology : Q01130 / serine and arginine rich splicing factor 2
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: E2
Gene start: 116849901
Gene end: 116853094
  
Corresponding Affymetrix probe sets: 10393395 (MoGene1.0st)   1415807_s_at (Mouse Genome 430 2.0 Array)   1427504_s_at (Mouse Genome 430 2.0 Array)   1427816_at (Mouse Genome 430 2.0 Array)   1452439_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090059
Ensembl peptide - ENSMUSP00000120086
Ensembl peptide - ENSMUSP00000134907
Ensembl peptide - ENSMUSP00000140016
NCBI entrez gene - 20382     See in Manteia.
MGI - MGI:98284
RefSeq - XM_011248835
RefSeq - NM_011358
RefSeq Peptide - NP_035488
swissprot - Q62093
swissprot - H3BJA4
Ensembl - ENSMUSG00000034120
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srsf2aENSDARG00000057484Danio rerio
 srsf2bENSDARG00000103893Danio rerio
 SRSF2ENSG00000161547Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9R0U0 / Srsf10 / serine/arginine-rich splicing factor 10 / O75494* / serine and arginine rich splicing factor 10*ENSMUSG0000002867640
4930595M18Rik / RIKEN cDNA 4930595M18 geneENSMUSG0000006067334
Q8C8K3 / Srsf12 / Serine/arginine-rich splicing factor 12 / Q8WXF0* / serine and arginine rich splicing factor 12*ENSMUSG0000005467924


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR003954  RNA recognition motif domain, eukaryote
 IPR034893  Serine/arginine-rich splicing factor 2-like
 IPR035979  RNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IEA
 biological_processGO:0000381 regulation of alternative mRNA splicing, via spliceosome IDA
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0033197 response to vitamin E IEA
 biological_processGO:0043484 regulation of RNA splicing IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005681 spliceosomal complex IDA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0035061 interchromatin granule IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005080 protein kinase C binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0036002 pre-mRNA binding IDA


Pathways (from Reactome)
Pathway description
Cleavage of Growing Transcript in the Termination Region
Transport of Mature mRNA derived from an Intron-Containing Transcript
mRNA Splicing - Major Pathway
mRNA Splicing - Minor Pathway
mRNA 3-end processing


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0000715 decreased thymocyte number "fewer than expected number of precursors to T cells; these cells are lymphoid cells found in the thymus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

Allelic Composition: Srsf2tm1Xdfu/Srsf2+,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * ICR

 MP:0001545 abnormal hematopoietic system physiology "anomalous function of the fluid and/or its suspended elements that circulate(s) through the heart, arteries, capillaries, and veins" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Srsf2tm1Xdfu/Srsf2tm1Xdfu,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0001601 abnormal myelopoiesis "atypical process of bone marrow cell formation and/or bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001603 failure of myelopoiesis "missing the process of bone marrow cell formation and/or the formation of bone marrow-derived blood cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:60896]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001606 impaired hematopoiesis "atypical process of blood cell formation with the result of fewer of these cells being formed" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Srsf2tm1Xdfu/Srsf2tm1Xdfu,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0002357 abnormal spleen white pulp morphology "anomalous structure or formation of the splenic area consisting of lymph nodules and diffuse lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0002811 macrocytic anemia "anemia in which the circulating erythrocyte corpuscular volume is larger than normal" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0004956 decreased thymus weight "reduction in the average weight of the primary lymphoid organ that is required for maturation of T cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Srsf2tm1Xdfu/Srsf2+,Tg(Lck-cre)I57Jxm/?
Genetic Background: involves: 129S4/SvJae * 129X1/SvJ * ICR

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0005065 abnormal neutrophil morphology "structural anomaly of the granular leukocytes that have a three- to five-lobed nucleus and a cytoplasm that contains inconspicuous granules stainable by neutral dyes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0005090 increased double-negative T cells count "greater than expected numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0005598 decreased ventricle muscle contractility "reduced ability of the heart ventricle muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0008028 pregnancy-related premature death "death occuring before the normal life span of an organism, occuring during pregnancy, parturition or lactation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Myl2tm1(cre)Krc/Myl2+,Srsf2tm1Xdfu/Srsf2tm1Xdfu
Genetic Background: involves: 129S4/SvJae

 MP:0008801 abnormal erythroid progenitor cell morphology "any structural anomaly of a progenitor cell committed to the erythroid lineage" [CL:0000038]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0010763 abnormal hematopoietic stem cell physiology "any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dchs1tm1.2Irv/Dchs1tm1.2Irv
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0013741 absent thymus corticomedullary boundary " complete absence or loss of the dense region demarcating the thymus medulla from the surrounding cortex that is characterized by numerous blood vessels (predominantly arterioles) with some perivascular connective tissue, mature and immature T lymphocytes, dendritic cells, variable numbers of perivascular B-lymphocytes and plasma cells; normally, this is the site of entry of bone marrow stem cells and exit of mature, functional T cells" [MGI:Anna, PMID:17067941]
Show

Allelic Composition: Crhr1tm1Wrst/Crhr1+
Genetic Background: either: (involves: 129P2/OlaHsd * 129P/Ola) or (involves: 129P2/OlaHsd * CD-1)

 MP:0013776 bone marrow failure "inherited or acquired dysfunction of hematopoietic stem cells that can result in abnormalities in one or more of the stem cell lineages (erythroid, myeloid, megakaryocytic)" [http://emedicine.medscape.com/article/199003-overview, MGI:llw2]
Show

Allelic Composition: Srsf2tm1Xdfu/Srsf2tm1Xdfu,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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