ENSMUSG00000028936


Mus musculus

Features
Gene ID: ENSMUSG00000028936
  
Biological name :Rpl22
  
Synonyms : P67984 / ribosomal protein L22 / Rpl22
  
Possible biological names infered from orthology : P35268
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 152325742
Gene end: 152334071
  
Corresponding Affymetrix probe sets: 10510720 (MoGene1.0st)   1416603_at (Mouse Genome 430 2.0 Array)   1448398_s_at (Mouse Genome 430 2.0 Array)   1453118_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099480
Ensembl peptide - ENSMUSP00000118787
Ensembl peptide - ENSMUSP00000140276
NCBI entrez gene - 19934     See in Manteia.
MGI - MGI:99262
RefSeq - NM_001277114
RefSeq - NM_001277113
RefSeq - NM_009079
RefSeq Peptide - NP_001264042
RefSeq Peptide - NP_001264043
RefSeq Peptide - NP_033105
swissprot - P67984
swissprot - Q4VAG4
Ensembl - ENSMUSG00000028936
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpl22ENSDARG00000070437Danio rerio
 RPL22ENSG00000116251Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9D7S7 / Rpl22l1 / ribosomal protein L22 like 1 / Q6P5R6*ENSMUSG0000003922170


Protein motifs (from Interpro)
Interpro ID Name
 IPR002671  Ribosomal protein L22e


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002181 cytoplasmic translation IBA
 biological_processGO:0006412 translation IEA
 biological_processGO:0046632 alpha-beta T cell differentiation IMP
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005840 ribosome ISS
 cellular_componentGO:0022625 cytosolic large ribosomal subunit IBA
 cellular_componentGO:0031012 extracellular matrix ISO
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0003735 structural constituent of ribosome IBA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000704 abnormal thymus development "anomaly in the formation and/or differentiation of the thymus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0001825 arrested T cell development "failure of T cell formation to proceed past a defined stage" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grem1ld-J/Grem1ld-J
Genetic Background: involves: CBA/Ca

Allelic Composition: Rpl22tm1.1Psam/Rpl22+,Tg(Amh-cre)8815Reb/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

Allelic Composition: Rpl22tm1.2Psam/Rpl22tm1.2Psam
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cr2tm1.1Jhws/Cr2tm1.1Jhws
Genetic Background: Not Specified

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

Allelic Composition: Rpl22Gt(YHB332)Byg/Rpl22Gt(YHB332)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005089 decreased double-negative T cell count "reduced numbers of the subset of T cells found in the thymus that express neither CD4 nor CD8 " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0006387 abnormal T cell number "deviation from the normal count of T cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0006413 increased T cell apoptosis "increase in the number of T cells undergoing programmed cell death" [MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: a/a,Hps6ru/Hps6ru
Genetic Background: B6.Cg-Hps6ru

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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