ENSMUSG00000028937


Mus musculus

Features
Gene ID: ENSMUSG00000028937
  
Biological name :Acot7
  
Synonyms : Acot7 / Cytosolic acyl coenzyme A thioester hydrolase / Q91V12
  
Possible biological names infered from orthology : acyl-CoA thioesterase 7 / O00154
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: E2
Gene start: 152178134
Gene end: 152271855
  
Corresponding Affymetrix probe sets: 10510687 (MoGene1.0st)   1417094_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030779
Ensembl peptide - ENSMUSP00000074827
Ensembl peptide - ENSMUSP00000101277
Ensembl peptide - ENSMUSP00000129121
NCBI entrez gene - 70025     See in Manteia.
MGI - MGI:1917275
RefSeq - XM_006539169
RefSeq - NM_001146057
RefSeq - NM_001146058
RefSeq - NM_133348
RefSeq Peptide - NP_001139529
RefSeq Peptide - NP_001139530
RefSeq Peptide - NP_579926
swissprot - Q91V12
swissprot - E9PYH2
Ensembl - ENSMUSG00000028937
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acot7ENSDARG00000018653Danio rerio
 ACOT7ENSGALG00000000652Gallus gallus
 ACOT7ENSG00000097021Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acot11 / Q8VHQ9 / acyl-CoA thioesterase 11 / Q8WXI4*ENSMUSG0000003485321
Acot12 / Q9DBK0 / acyl-CoA thioesterase 12 / Q8WYK0*ENSMUSG0000002162020


Protein motifs (from Interpro)
Interpro ID Name
 IPR006683  Thioesterase domain
 IPR029069  HotDog domain superfamily
 IPR033120  Hotdog acyl-CoA thioesterase (ACOT)-type domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006637 acyl-CoA metabolic process IBA
 biological_processGO:0009062 fatty acid catabolic process IDA
 biological_processGO:0015937 coenzyme A biosynthetic process IEA
 biological_processGO:0036114 medium-chain fatty-acyl-CoA catabolic process IEA
 biological_processGO:0036116 long-chain fatty-acyl-CoA catabolic process IEA
 biological_processGO:0051792 medium-chain fatty acid biosynthetic process IEA
 biological_processGO:1900535 palmitic acid biosynthetic process IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0044297 cell body IDA
 molecular_functionGO:0000062 fatty-acyl-CoA binding IEA
 molecular_functionGO:0016290 palmitoyl-CoA hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036042 long-chain fatty acyl-CoA binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0047617 acyl-CoA hydrolase activity IEA
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA
 molecular_functionGO:0102991 myristoyl-CoA hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Mitochondrial Fatty Acid Beta-Oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0001402 hypoactivity "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0001554 increased circulating free fatty acid level "higher than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:65146]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0002183 gliosis "increased growth pattern of neuroglia in a damaged area of the brain or spinal cord" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0002229 CNS neurodegeneration "a retrogressive impairment of function or destruction of neural tissue" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0003949 abnormal circulating lipid level "anomalous concentrations of fat-soluble substances (molecules composed of carbon and hydrogen and are characteristically insoluble in water) in the blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0005317 increased triglyceride level "higher than normal concentration of triacylglycerols " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0008948 decreased neuron number "fewer than normal numbers of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:A08.663]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0009285 increased gonadal fat pad weight "greater than average weight of the encapsulated adipose tissue associated with the ovaries or testes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0009292 increased inguinal fat pad weight 
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0009355 increased liver triglyceride level "higher than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0010024 increased total body fat amount "greater than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

 MP:0020523 decreased susceptibility to induced hypothermia "smaller than expected drop in body temperature in response to treatment (cold-exposure, dietary restriction, ethanol treatment, etc..) designed to induce hypothermia" [MGI:mperry, PMID:24531262]
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Allelic Composition: Cadm4tm1.1Pele/Cadm4tm1.1Pele,Tg(Dhh-cre)1Mejr/0
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028937 Acot7 / Q91V12 / Cytosolic acyl coenzyme A thioester hydrolase / O00154* / acyl-CoA thioesterase 7*  / complex






 

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