ENSMUSG00000034853


Mus musculus

Features
Gene ID: ENSMUSG00000034853
  
Biological name :Acot11
  
Synonyms : Acot11 / acyl-CoA thioesterase 11 / Q8VHQ9
  
Possible biological names infered from orthology : Q8WXI4
  
Species: Mus musculus
  
Chr. number: 4
Strand: -1
Band: C7
Gene start: 106744555
Gene end: 106804998
  
Corresponding Affymetrix probe sets: 10514865 (MoGene1.0st)   1425667_at (Mouse Genome 430 2.0 Array)   1429267_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000099823
Ensembl peptide - ENSMUSP00000125123
Ensembl peptide - ENSMUSP00000124567
Ensembl peptide - ENSMUSP00000124385
Ensembl peptide - ENSMUSP00000123942
Ensembl peptide - ENSMUSP00000069636
NCBI entrez gene - 329910     See in Manteia.
MGI - MGI:1913736
RefSeq - XM_011240556
RefSeq - NM_001347159
RefSeq - NM_025590
RefSeq - XM_006503181
RefSeq Peptide - NP_001334088
RefSeq Peptide - NP_079866
swissprot - E0CYS0
swissprot - Q543P6
swissprot - E0CXP8
swissprot - A2AVR6
swissprot - E0CYA0
swissprot - F6SS52
swissprot - Q8VHQ9
Ensembl - ENSMUSG00000034853
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acot11aENSDARG00000058229Danio rerio
 acot11bENSDARG00000042122Danio rerio
 ACOT11ENSGALG00000010785Gallus gallus
 ACOT11ENSG00000162390Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Acot12 / Q9DBK0 / acyl-CoA thioesterase 12 / Q8WYK0*ENSMUSG0000002162042
Acot7 / Q91V12 / Cytosolic acyl coenzyme A thioester hydrolase / O00154* / acyl-CoA thioesterase 7*ENSMUSG0000002893713


Protein motifs (from Interpro)
Interpro ID Name
 IPR002913  START domain
 IPR006683  Thioesterase domain
 IPR023393  START-like domain superfamily
 IPR029069  HotDog domain superfamily
 IPR033120  Hotdog acyl-CoA thioesterase (ACOT)-type domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006631 fatty acid metabolic process IBA
 biological_processGO:0006637 acyl-CoA metabolic process IBA
 biological_processGO:0009266 response to temperature stimulus IEP
 biological_processGO:0009409 response to cold IEP
 biological_processGO:0035556 intracellular signal transduction NAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0047617 acyl-CoA hydrolase activity TAS
 molecular_functionGO:0052689 carboxylic ester hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Mitochondrial Fatty Acid Beta-Oxidation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000005 increased brown fat amount "increased amount of thermogenic tissue in the body that is composed of cells containing multiple small fat droplets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:14208]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0000186 decreased circulating HDL cholesterol level "lower than average level of high density lipoprotein in blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0004889 increased energy expenditure "increase in the number of calories used per unit time or decrease in weight gain for a given amount of food eaten" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0005281 increased fatty acid level "higher than normal non-circulating level of organic, monobasic acids derived from hydrocarbons; they are saturated and unsaturated" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0005289 increased oxygen consumption "greater than the normal rate at which oxygen enters the blood from alveolar gas; this is equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0005659 resistance to diet-induced obesity "less likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0009116 abnormal brown fat cell morphology "any structural anomaly of cells from the thermogenic form of adipose tissue found in newborns of many species, including humans, and in hibernating mammals; brown fat is capable of rapid liberation of energy and seems to be important in the maintenance of body temperature immediately after birth and upon waking from hibernation; brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria" [CL:0000449, GO:0050873, MESH:A.10.165.114.322]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0009125 decreased brown fat cell lipid droplet size "reduction in the size of the multiple small droplets of triglycerides found in brown adipocytes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0010378 increased respiratory quotient "increase in the ratio of the volume of carbon dioxide released to oxygen consumed by a body tissue or an organism compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0011698 abnormal brown adipose tissue physiology "any functional anomaly in the thermogenic form of adipose tissue that is composed of brown adipocytes" [MGI:smb]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0011699 abnormal brown adipose tissue thermogenesis "any anomaly in the process of heat production in brown adipocytes" [MGI:smb]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0011939 increased food intake "increase in the total number of calories/food amount taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0014171 increased fatty acid oxidation "increased rate or incidence of the process of removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen" [GO:0019395]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

 MP:0030016 increased adipocyte glucose uptake "increased ability of adipocytes to take in glucose" [MGI:anna]
Show

Allelic Composition: Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo/Gt(ROSA)26Sortm1.3(CAG-mTFP1)Imayo
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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