MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Lbric-J/Lbr+ Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
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MP:0001265 | reduced body size | "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170] |
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Allelic Composition: Lbric-J/Lbr+ Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
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MP:0001402 | hypoactivity | "reduced movement from one place to another" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:64289] |
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+ Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H
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MP:0001406 | abnormal gait | "unusual or distinctive way of walking" [J:65038] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0001407 | short stride length | "reduced average distance between steps" [J:34193] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0001516 | abnormal motor coordination/ balance | "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0002083 | premature death | "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Lbric-J/Lbr+ Genetic Background: (NZW/LacJ x C57BL/6J-Lbric-J/J)F1
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MP:0002690 | akinesia | "absence of movement or loss of the ability to move such as temporary or prolonged paralysis or "freezing in place"" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:82238] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0002757 | reduced vertical activity | "lesser than average time spent jumping or rearing" [J:82829, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0002764 | short tibia | " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+ Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H
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MP:0003186 | abnormal redox activity | "defect in the processes that maintain the redox environment of a cell or compartment within a cell " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi Genetic Background: involves: C57BL/6N
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MP:0003224 | neuron degeneration | "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0003244 | loss of dopaminergic neurons | "loss of the neurons that utilize dopamine as a neurotransmitter, commonly due to an apoptotic event" [RGD:Rat Genome Database submission] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0003313 | abnormal locomotor activation | "altered ability or desire of an animal to initiate locomotor activity" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+ Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H
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MP:0003674 | oxidative stress | "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0004924 | abnormal behavior | "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+ Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H
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MP:0005156 | bradykinesia | "decreased spontaneity and movement" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83301] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0005419 | hypoalbuminemia | "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+ Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H
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MP:0005560 | decreased circulating glucose level | "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+ Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H
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MP:0005567 | decreased circulating total protein level | "less than the average total concentration of these macromolecules in the blood " [RGD:Rat Genome Database submission] |
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+ Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H
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MP:0005643 | decreased dopamine level | "less than the normal concentration of this catecholamine neurotransmitter, dervied from tyrosine and the precursor to norepinephrine and epinephrine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:88298] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0006035 | abnormal mitochondrial morphology | "anomalous structure of the mitochondria" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
Allelic Composition: Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi Genetic Background: involves: C57BL/6N
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MP:0006036 | abnormal mitochondrial physiology | |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0008656 | abnormal interleukin-1 beta secretion | "anomaly in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi Genetic Background: involves: C57BL/6N
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MP:0008658 | decreased interleukin-1 beta secretion | "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600] |
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Allelic Composition: Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi Genetic Background: involves: C57BL/6N
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MP:0008770 | decreased survivor rate | "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"] |
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Allelic Composition: Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi Genetic Background: involves: C57BL/6N
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MP:0011075 | abnormal macrophage activation involved in immune response | "anomaly in the process in which a change in morphology and behavior of a macrophage results from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response" [GO:0002281] |
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Allelic Composition: Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi Genetic Background: involves: C57BL/6N
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MP:0011101 | partial prenatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi Genetic Background: involves: C57BL/6N
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MP:0011633 | abnormal mitochondrial shape | "any anomaly in the characteristic surface outline or contour of a mitochondria" [MGI:csmith] |
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Allelic Composition: Pgam5tm1d(EUCOMM)Wtsi/Pgam5tm1d(EUCOMM)Wtsi Genetic Background: involves: C57BL/6N
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MP:0011635 | abnormal mitochondrial crista morphology | "Any of the inward folds of the mitochondrial inner membrane; crista number, extent, and shape differ in mitochondria from different tissues and organisms; crista appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found; the shape can vary with the respiratory state of the mitochondria" [GO:0030061] |
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Allelic Composition: Arhgap28tm2b(KOMP)Wtsi/Arhgap28tm2b(KOMP)Wtsi Genetic Background: involves: C57BL/6J * C57BL/6N
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MP:0011965 | decreased total retina thickness | "decreased width of the retina through the center plane" [MGI:csmith] |
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Allelic Composition: Pdgfrbtm1b(EUCOMM)Hmgu/Pdgfrb+ Genetic Background: C57BL/6N-Pdgfrbtm1b(EUCOMM)Hmgu/H
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