ENSMUSG00000029556


Mus musculus

Features
Gene ID: ENSMUSG00000029556
  
Biological name :Hnf1a
  
Synonyms : Hepatocyte nuclear factor 1-alpha / Hnf1a / P22361
  
Possible biological names infered from orthology : HNF1 homeobox A / P20823
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: F
Gene start: 114948980
Gene end: 114971094
  
Corresponding Affymetrix probe sets: 10532907 (MoGene1.0st)   1421234_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000031535
Ensembl peptide - ENSMUSP00000135539
Ensembl peptide - ENSMUSP00000135678
NCBI entrez gene - 21405     See in Manteia.
MGI - MGI:98504
RefSeq - XM_011248192
RefSeq - NM_009327
RefSeq Peptide - NP_033353
swissprot - H3BKV2
swissprot - P22361
swissprot - H3BL72
Ensembl - ENSMUSG00000029556
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HNF1AENSGALG00000006968Gallus gallus
 HNF1AENSG00000135100Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hnf1b / P27889 / Hepatocyte nuclear factor 1-beta / P35680* / HNF1 homeobox B*ENSMUSG0000002067948
Hmbox1 / Q8BJA3 / Mus musculus homeobox containing 1 (Hmbox1), transcript variant 3, mRNA. / Q6NT76* / homeobox containing 1*ENSMUSG0000002197214


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR006897  Hepatocyte nuclear factor 1, beta isoform, C-terminal
 IPR006898  Hepatocyte nuclear factor 1, alpha isoform C-terminal
 IPR006899  Hepatocyte nuclear factor 1, N-terminal
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR023219  Hepatocyte nuclear factor 1, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001779 natural killer cell differentiation ISO
 biological_processGO:0001824 blastocyst development IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001890 placenta development IGI
 biological_processGO:0006338 chromatin remodeling IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IMP
 biological_processGO:0006357 regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006633 fatty acid biosynthetic process IMP
 biological_processGO:0006699 bile acid biosynthetic process IMP
 biological_processGO:0006783 heme biosynthetic process IMP
 biological_processGO:0006979 response to oxidative stress IMP
 biological_processGO:0008104 protein localization IMP
 biological_processGO:0008203 cholesterol metabolic process IMP
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0015721 bile acid and bile salt transport IMP
 biological_processGO:0015908 fatty acid transport IMP
 biological_processGO:0016573 histone acetylation IMP
 biological_processGO:0030073 insulin secretion ISO
 biological_processGO:0030111 regulation of Wnt signaling pathway IGI
 biological_processGO:0030326 embryonic limb morphogenesis IGI
 biological_processGO:0031018 endocrine pancreas development IMP
 biological_processGO:0035623 renal glucose absorption IDA
 biological_processGO:0042593 glucose homeostasis IDA
 biological_processGO:0043691 reverse cholesterol transport IMP
 biological_processGO:0045453 bone resorption IGI
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046323 glucose import IDA
 biological_processGO:0046883 regulation of hormone secretion IMP
 biological_processGO:0048341 paraxial mesoderm formation IGI
 biological_processGO:0048608 reproductive structure development IMP
 biological_processGO:0050796 regulation of insulin secretion IMP
 biological_processGO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter ISO
 biological_processGO:0060395 SMAD protein signal transduction IDA
 cellular_componentGO:0001750 photoreceptor outer segment IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005667 transcription factor complex IPI
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0045120 pronucleus IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001221 transcription cofactor binding IEA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISO
 molecular_functionGO:0046983 protein dimerization activity ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0000473 abnormal stomach glandular epithelium morphology "malformation of the gland-containing epithelial layer of the stomach" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:tc, J:54637]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
Show

Allelic Composition: Hnf1atm2Ylee/Hnf1atm2Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001156 abnormal spermatogenesis "incomplete maturation or aberrant formation of the male gametes" [J:58959]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0001433 polyphagia "eating to excess" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001762 polyuria "increased volume of urine produced and excreted" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001924 infertility "inability to produce live offspring" [J:47225]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm2Ylee/Hnf1atm2Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002566 abnormal sexual interaction "altered initiation, failure of initiation or incomplete mating behavior" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcmt1tm1Shs/Pcmt1tm1Shs
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002628 fatty liver "an accumulation of fat deposits in the liver " [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm2Ylee,Speer6-ps1Tg(Alb-cre)21Mgn/?
Genetic Background: involves: 129X1/SvJ * C57BL/6 * DBA

 MP:0002901 hyperphosphaturia "an increase of excretion of phosphates in the urine" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002985 abnormal urine calcium level "any change in the level of excretion of calcium in the urine" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0003325 decreased liver function "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0003339 decreased number of pancreatic beta cells "fewer than normal number of the cells of the pancreas that secrete insulin" [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0003893 increased hepatocyte proliferation "anomalous growth and reproduction of hepatocyte cells of the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0003982 increased cholesterol level "greater than normal concentration in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004701 decreased circulating insulin-like growth factor I level "reduced blood concentration of this polypeptide hormone with growth-regulating, insulin-like, and mitogenic activities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005123 increased circulating growth hormone level "greater than the expected blood concentration of the hormone that promotes body growth, fat mobilization, and inhibition of glucose utilization" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0005215 abnormal islet of Langerhans morphology "anomalous morphology of these structures that are scattered throughout the pancreas and comprise its endocrine portion; within each islet there are three cell types: alpha, beta, and delta " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0005309 increased circulating ammonia level "significantly elevated levels of ammonia or its compounds in blood; often associated with liver failure and hepatic encephalopathy " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83263]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0005343 increased circulating aspartate transaminase level "greater than normal concentration in the blood of this enzyme, which catalyzes the reversible transfer of an amine group from l-glutamic acid to oxaloacetic acid, forming alpha-ketoglutaric acid and l-aspartic acid; aids in diagnosis of viral hepatitis and myocardial infarction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0005448 abnormal energy balance "aberrant intake or expenditure of calories as compared to the normal state" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0005528 decreased glomerular filtration rate "less than the normal volume of water filtered out of the plasma through glomerular capillary walls into thte Bowman s capsule per unit time" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0005558 decreased creatinine clearance "less than the normal amount of this creatine metabolite filtered by the kidneys in a specific period of time; indicative of kidney function" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0009810 increased urine uric acid level "greater concentration in the urine of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm1.1Ylee/Hnf1atm1.1Ylee
Genetic Background: involves: 129X1/SvJ * C57BL/6J

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0011447 abnormal renal glucose reabsorption "any anomaly in the process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron" [GO:0035623]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0011765 oroticaciduria "increased level of orotic acid, an intermediate of pyrimidine synthesis, in the urine" [MGI:anna]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0020401 argininuria "excretion of excessive amounts of arginine in the urine" [HP:0003268]
Show

Allelic Composition: Adamts1tm1Mlia/Adamts1tm1Mlia
Genetic Background: involves: 129X1/SvJ * BALB/c

Allelic Composition: Hnf1atm2Mya/Hnf1atm2Mya
Genetic Background: involves: 129S2/SvPas

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr