ENSMUSG00000020679


Mus musculus

Features
Gene ID: ENSMUSG00000020679
  
Biological name :Hnf1b
  
Synonyms : Hepatocyte nuclear factor 1-beta / Hnf1b / P27889
  
Possible biological names infered from orthology : HNF1 homeobox B / P35680
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 83850063
Gene end: 83905819
  
Corresponding Affymetrix probe sets: 10379765 (MoGene1.0st)   1421224_a_at (Mouse Genome 430 2.0 Array)   1451687_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000103748
Ensembl peptide - ENSMUSP00000117036
Ensembl peptide - ENSMUSP00000123297
Ensembl peptide - ENSMUSP00000021016
Ensembl peptide - ENSMUSP00000103749
NCBI entrez gene - 21410     See in Manteia.
MGI - MGI:98505
RefSeq - XM_006532796
RefSeq - NM_001291268
RefSeq - NM_001291269
RefSeq - NM_009330
RefSeq - XM_006532791
RefSeq - XM_006532793
RefSeq - XM_006532794
RefSeq Peptide - NP_033356
RefSeq Peptide - NP_001278197
RefSeq Peptide - NP_001278198
swissprot - F6XBL0
swissprot - P27889
swissprot - A0A0A0MQH4
Ensembl - ENSMUSG00000020679
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hnf1baENSDARG00000006615Danio rerio
 hnf1bbENSDARG00000022295Danio rerio
 HNF1BENSGALG00000005504Gallus gallus
 HNF1BENSG00000275410Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hnf1a / P22361 / Hepatocyte nuclear factor 1-alpha / P20823* / HNF1 homeobox A*ENSMUSG0000002955654
Hmbox1 / Q8BJA3 / Mus musculus homeobox containing 1 (Hmbox1), transcript variant 3, mRNA. / Q6NT76* / homeobox containing 1*ENSMUSG0000002197217


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR006897  Hepatocyte nuclear factor 1, beta isoform, C-terminal
 IPR006899  Hepatocyte nuclear factor 1, N-terminal
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily
 IPR023219  Hepatocyte nuclear factor 1, N-terminal domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0001706 endoderm formation ISO
 biological_processGO:0001714 endodermal cell fate specification IMP
 biological_processGO:0001822 kidney development ISS
 biological_processGO:0001826 inner cell mass cell differentiation IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007219 Notch signaling pathway IDA
 biological_processGO:0007492 endoderm development IMP
 biological_processGO:0009743 response to carbohydrate IEA
 biological_processGO:0009749 response to glucose IMP
 biological_processGO:0009952 anterior/posterior pattern specification IMP
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0030073 insulin secretion IMP
 biological_processGO:0030111 regulation of Wnt signaling pathway IMP
 biological_processGO:0030902 hindbrain development IMP
 biological_processGO:0031018 endocrine pancreas development ISS
 biological_processGO:0032922 circadian regulation of gene expression IEA
 biological_processGO:0035565 regulation of pronephros size ISO
 biological_processGO:0039020 pronephric nephron tubule development ISO
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042663 regulation of endodermal cell fate specification IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISS
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0048557 embryonic digestive tract morphogenesis IMP
 biological_processGO:0048598 embryonic morphogenesis IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IMP
 biological_processGO:0048793 pronephros development ISO
 biological_processGO:0048806 genitalia development ISS
 biological_processGO:0050673 epithelial cell proliferation IMP
 biological_processGO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter ISO
 biological_processGO:0060429 epithelium development IMP
 biological_processGO:0060677 ureteric bud elongation IMP
 biological_processGO:0060993 kidney morphogenesis IGI
 biological_processGO:0061017 hepatoblast differentiation IMP
 biological_processGO:0061296 negative regulation of mesenchymal cell apoptotic process involved in mesonephric nephron morphogenesis IMP
 biological_processGO:0065004 protein-DNA complex assembly IEA
 biological_processGO:0070365 hepatocyte differentiation IEA
 biological_processGO:0072095 regulation of branch elongation involved in ureteric bud branching IMP
 biological_processGO:0072164 mesonephric tubule development IGI
 biological_processGO:0072176 nephric duct development IMP
 biological_processGO:0072177 mesonephric duct development IMP
 biological_processGO:0072179 nephric duct formation IMP
 biological_processGO:0072181 mesonephric duct formation IMP
 biological_processGO:1900212 negative regulation of mesenchymal cell apoptotic process involved in metanephros development IMP
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005667 transcription factor complex IPI
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IBA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0003700 DNA-binding transcription factor activity ISO
 molecular_functionGO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0046982 protein heterodimerization activity IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000519 hydronephrosis "dilation of the pelvis and calices of one or both kidneys" [J:56641]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0000611 jaundice "clinical manifestation of hyperbilirubinemia, with deposition of bile pigments in the skin, resulting in yellowish staining of the skin and mucous membranes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

 MP:0001696 failure to gastrulate "inability to differentiate and invaginate the primary germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:34458]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001724 abnormal extraembryonic endoderm formation "malformation of the endoderm of the extraembryonic tissue that appears prior to gastrulation and performs critical functions during embryogenesis including nutrient uptake and transport from the mother to the embryo" [J:62628]
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Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002084 abnormal developmental patterning "abnormal systematic arrangement of the developing body along an axis" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002085 abnormal embryonic tissue morphology "structural abnormality or development of any embryonic tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002135 abnormal kidney morphology "abnormal development of the kidney resulting in structural abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0002138 abnormal liver/biliary system morphology "structural abnormality or aberrant development of any of the tissues of the liver or biliary system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002139 abnormal liver/biliary system physiology "altered function of the liver not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0002582 disorganized extraembryonic tissue "a lack of the regular arrangement of the membranes involved with the embryo s protection and nutrition" [J:40596, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002663 failure to form blastocele "developmental anomaly resulting in the absence of the cavity in the blastula of the developing embryo" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:19904]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0002703 abnormal renal tubules "anomalous structure or development of the loops of Henle and collecting ducts in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Hnf1btm1Ics/Hnf1b+,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0002718 abnormal inner cell mass "malformed or absent cells of the blastocyst that develop into the body of the embryo" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

 MP:0003252 abnormal bile duct physiology "anomalous action or function of the channels that secrete bile from the liver to the gall bladder and intestines" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003325 decreased liver function "reduced normal function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [ncbi:Matthew Mailman, NCBI request, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0003886 abnormal embryonic epiblast morphology "anomaly in the development/organization of the tissue that gives rise to the ectoderm, endoderm and mesoderm of the embryo proper" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

 MP:0003988 disorganized embryonic tissue "a lack of the regular arrangement of any embryonic tissues" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:58080]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0004755 abnormal loop of Henle "any structural anomaly of the section of the renal tubule in the kidney medulla with a hairpin bend; consists of a descending limb and an ascending limb, and is situated between the proximal convoluted tubule to the distal convoluted tubule; it functions to reabsorb water and ions from the urine" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0005084 abnormal gall bladder morphology "anomalous structure or development of the organ which serves as a storage reservoir for bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005344 increased circulating bilirubin level "greater than the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:85204]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0005415 intrahepatic cholestasis "impariment of bile flow due to injury to the hepatocytes, bile canaliculi, or the intrahepatic bile ducts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009493 abnormal cystic duct morphology "any structural anomaly of the tubular structure that conducts gall bladder contents from the gall bladder to the common bile duct" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009497 abnormal intrahepatic bile duct morphology "any structural anomaly of the passages within the liver for the conveyance of bile" [MESH:A03.159.183.158]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009498 abnormal extrahepatic bile duct morphology "any structural anomaly of the passages external to the liver for the conveyance of bile" [MESH:A03.159.183.079]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0009500 abnormal interlobular bile duct morphology "any structural anomaly of the canals that carry bile in the liver between the intralobular ducts and the biliary ductules; interlobular bile ducts are part of the interlobular portal triad" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Skiltm2Spw/Skiltm2Spw
Genetic Background: either: (involves: 129S1/Sv * 129X1/SvJ) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Gsk3btm1Grc/Gsk3b+
Genetic Background: involves: 129S6/SvEvTac

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

Allelic Composition: Hnf1btm2Mya/Hnf1btm2Mya
Genetic Background: involves: 129S2/SvPas

 MP:0011183 abnormal primitive endoderm morphology "any structural anomaly of the monolayer of cells derived from and located on the surface of inner cell mass, directly facing the blastocoele, and is separated from the more centrally located epiblast by basal lamina; the primitive endoderm give rises to the visceral endoderm and the parietal endoderm" [PMID:21123814]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
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Allelic Composition: Krt25Re/Krt25+
Genetic Background: Not Specified

 MP:0011198 absent proamniotic cavity "absence of the cavity of the developing embryo that is formed within the epiblast tissue prior to the closing of the proamniotic canal by the amniotic folds" [ISBN:0-12-402035-6]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

 MP:0011207 absent ectoplacental cavity "absence of the closed space within the ectoplacental cone, formed by the fusion of the parts of the amniotic fold that separate it from the amniotic cavity" [ISBN:0-12-402035-6]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

 MP:0011364 abnormal metanephros morphology "any structural anomaly of the primordium of the permanent kidney, which develops later than and caudal to the mesonephros, from the mesonephric duct and nephrogenic cord; the metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine" [GO:0001656]
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Allelic Composition: Hnf1btm1Ics/Hnf1btm1Sce,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0011682 renal glomerulus cysts "abnormal membranous sacs in any portion of the renal glomerulus" [MGI:csmith]
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Allelic Composition: Hnf1btm1Ics/Hnf1btm1Sce,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Hnf1btm1Ics/Hnf1b+,Wnt4tm2(EGFP/cre)Svo/Wnt4+
Genetic Background: involves: 129P2/OlaHsd

 MP:0012158 absent visceral endoderm "absence of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [MGI:anna]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

 MP:0012162 absent parietal endoderm "absence of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [MGI:anna]
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Allelic Composition: Hnf1btm1Sce/Hnf1btm1Sce
Genetic Background: either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * C57BL/6J) or (involves: 129P2/OlaHsd * C57BL/6J * DBA/2)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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