ENSMUSG00000021972


Mus musculus

Features
Gene ID: ENSMUSG00000021972
  
Biological name :Hmbox1
  
Synonyms : Hmbox1 / Mus musculus homeobox containing 1 (Hmbox1), transcript variant 3, mRNA. / Q8BJA3
  
Possible biological names infered from orthology : homeobox containing 1 / Q6NT76
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: D1
Gene start: 64811600
Gene end: 64949871
  
Corresponding Affymetrix probe sets: 10420823 (MoGene1.0st)   1436341_at (Mouse Genome 430 2.0 Array)   1443020_at (Mouse Genome 430 2.0 Array)   1452449_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135657
Ensembl peptide - ENSMUSP00000022544
Ensembl peptide - ENSMUSP00000066905
Ensembl peptide - ENSMUSP00000134824
Ensembl peptide - ENSMUSP00000135211
Ensembl peptide - ENSMUSP00000135272
Ensembl peptide - ENSMUSP00000135372
Ensembl peptide - ENSMUSP00000135448
NCBI entrez gene - 219150     See in Manteia.
MGI - MGI:2445066
RefSeq - XM_017315979
RefSeq - XM_006518890
RefSeq - XM_006518892
RefSeq - XM_011245029
RefSeq - XM_011245030
RefSeq - XM_011245031
RefSeq - XM_011245033
RefSeq - XM_011245034
RefSeq - XM_011245035
RefSeq - XM_011245036
RefSeq - XM_011245037
RefSeq - NM_001347627
RefSeq - NM_177338
RefSeq - XM_006518882
RefSeq Peptide - NP_001334555
RefSeq Peptide - NP_001334556
RefSeq Peptide - NP_796312
swissprot - H3BL55
swissprot - H3BK13
swissprot - H3BK67
swissprot - H3BJ31
swissprot - Q8BJA3
swissprot - H3BKF8
swissprot - H3BKM3
Ensembl - ENSMUSG00000021972
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01078261.1ENSDARG00000109287Danio rerio
 hmbox1aENSDARG00000027082Danio rerio
 HMBOX1ENSGALG00000016633Gallus gallus
 HMBOX1ENSG00000147421Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hnf1b / P27889 / Hepatocyte nuclear factor 1-beta / P35680* / HNF1 homeobox B*ENSMUSG0000002067923
Hnf1a / P22361 / Hepatocyte nuclear factor 1-alpha / P20823* / HNF1 homeobox A*ENSMUSG0000002955620


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001387  Cro/C1-type helix-turn-helix domain
 IPR006899  Hepatocyte nuclear factor 1, N-terminal
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II ISO
 biological_processGO:0006278 RNA-dependent DNA biosynthetic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase ISO
 biological_processGO:0035563 positive regulation of chromatin binding IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051973 positive regulation of telomerase activity ISO
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005697 telomerase holoenzyme complex ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016604 nuclear body ISO
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding ISO
 molecular_functionGO:0003720 telomerase activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042162 telomeric DNA binding IDA
 molecular_functionGO:0042802 identical protein binding ISO
 molecular_functionGO:0043565 sequence-specific DNA binding ISO
 molecular_functionGO:0044877 protein-containing complex binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mmp14tm1Stjw/Mmp14tm1Stjw,Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background: involves: C57BL/6 * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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contact: otassy@igbmc.fr