ENSG00000147421


Homo sapiens

Features
Gene ID: ENSG00000147421
  
Biological name :HMBOX1
  
Synonyms : HMBOX1 / homeobox containing 1 / Q6NT76
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: p21.1
Gene start: 28890394
Gene end: 29064764
  
Corresponding Affymetrix probe sets: 219269_at (Human Genome U133 Plus 2.0 Array)   225504_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453185
Ensembl peptide - ENSP00000453211
Ensembl peptide - ENSP00000475196
Ensembl peptide - ENSP00000287701
Ensembl peptide - ENSP00000380516
Ensembl peptide - ENSP00000429767
Ensembl peptide - ENSP00000429854
Ensembl peptide - ENSP00000430059
Ensembl peptide - ENSP00000430110
Ensembl peptide - ENSP00000430238
Ensembl peptide - ENSP00000452827
NCBI entrez gene - 79618     See in Manteia.
RefSeq - NM_001324385
RefSeq - NM_001135726
RefSeq - NM_001324382
RefSeq - NM_001324383
RefSeq - NM_001324384
RefSeq - NM_001324386
RefSeq - NM_001324387
RefSeq - NM_001324388
RefSeq - NM_001324389
RefSeq - NM_001324390
RefSeq - NM_001324391
RefSeq - NM_001324392
RefSeq - NM_001324393
RefSeq - NM_001324394
RefSeq - NM_001324395
RefSeq - NM_024567
RefSeq - XM_005273635
RefSeq - XM_005273641
RefSeq - XM_006716398
RefSeq - XM_017013823
RefSeq - XM_017013824
RefSeq - XM_017013825
RefSeq Peptide - NP_001129198
RefSeq Peptide - NP_001311312
RefSeq Peptide - NP_001311322
RefSeq Peptide - NP_001311323
RefSeq Peptide - NP_001311324
RefSeq Peptide - NP_001317427
RefSeq Peptide - NP_078843
RefSeq Peptide - NP_001311311
RefSeq Peptide - NP_001311313
RefSeq Peptide - NP_001311314
RefSeq Peptide - NP_001311315
RefSeq Peptide - NP_001311316
RefSeq Peptide - NP_001311317
RefSeq Peptide - NP_001311318
RefSeq Peptide - NP_001311319
RefSeq Peptide - NP_001311320
RefSeq Peptide - NP_001311321
swissprot - E5RHH9
swissprot - H0YBM8
swissprot - H0YKJ1
swissprot - H0YLF2
swissprot - E5RGZ2
swissprot - Q6NT76
Ensembl - ENSG00000147421
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01078261.1ENSDARG00000109287Danio rerio
 hmbox1aENSDARG00000027082Danio rerio
 HMBOX1ENSGALG00000016633Gallus gallus
 Hmbox1ENSMUSG00000021972Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HNF1B / P35680 / HNF1 homeobox BENSG0000027541022
HNF1A / P20823 / HNF1 homeobox AENSG0000013510019


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001387  Cro/C1-type helix-turn-helix domain
 IPR006899  Hepatocyte nuclear factor 1, N-terminal
 IPR009057  Homeobox-like domain superfamily
 IPR010982  Lambda repressor-like, DNA-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0006278 RNA-dependent DNA biosynthetic process IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0035563 positive regulation of chromatin binding ISS
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 cellular_componentGO:0000784 nuclear chromosome, telomeric region IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005697 telomerase holoenzyme complex IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016604 nuclear body IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
 molecular_functionGO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IC
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003691 double-stranded telomeric DNA binding IDA
 molecular_functionGO:0003720 telomerase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042162 telomeric DNA binding IMP
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0044877 protein-containing complex binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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