ENSMUSG00000029920


Mus musculus

Features
Gene ID: ENSMUSG00000029920
  
Biological name :Smarcad1
  
Synonyms : Q04692 / Smarcad1 / SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  
Possible biological names infered from orthology : Q9H4L7
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: C1
Gene start: 65042583
Gene end: 65116061
  
Corresponding Affymetrix probe sets: 10538755 (MoGene1.0st)   1435651_a_at (Mouse Genome 430 2.0 Array)   1452276_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000144776
Ensembl peptide - ENSMUSP00000145340
Ensembl peptide - ENSMUSP00000145262
Ensembl peptide - ENSMUSP00000145228
Ensembl peptide - ENSMUSP00000145195
Ensembl peptide - ENSMUSP00000145152
Ensembl peptide - ENSMUSP00000031984
Ensembl peptide - ENSMUSP00000144767
NCBI entrez gene - 13990     See in Manteia.
MGI - MGI:95453
RefSeq - XM_011241205
RefSeq - XM_006505513
RefSeq - XM_006505512
RefSeq - XM_006505510
RefSeq - NM_001253392
RefSeq - NM_001355250
RefSeq - XM_006505509
RefSeq - NM_007958
RefSeq Peptide - NP_001240321
RefSeq Peptide - NP_001342179
RefSeq Peptide - NP_031984
swissprot - Q04692
swissprot - A0A0N4SVV9
swissprot - A0A0N4SUP7
swissprot - A0A0N4SUQ5
swissprot - A0A0N4SVP9
swissprot - A0A0N4SVS7
Ensembl - ENSMUSG00000029920
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 B0R061ENSDARG00000014041Danio rerio
 E7F1C4ENSDARG00000073721Danio rerio
 SMARCAD1ENSGALG00000037339Gallus gallus
 Q9H4L7ENSG00000163104Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000330  SNF2-related, N-terminal domain
 IPR001650  Helicase, C-terminal
 IPR003892  Ubiquitin system component Cue
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000018 regulation of DNA recombination ISS
 biological_processGO:0000729 DNA double-strand break processing IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0043044 ATP-dependent chromatin remodeling IEA
 biological_processGO:0051304 chromosome separation IEA
 biological_processGO:0070932 histone H3 deacetylation IEA
 biological_processGO:0070933 histone H4 deacetylation IEA
 cellular_componentGO:0000792 heterochromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0035861 site of double-strand break IEA
 cellular_componentGO:0043596 nuclear replication fork IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding ISO
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000154 rib fusion "appearance of one or more ribs as a single structure" [J:62022, J:62023]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000462 abnormal digestive system morphology "anomalous structure of the system dedicated to the mechanical, chemical, and enzymatic processing of food" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001625 cardiac hypertrophy "an increase in size of the cardiac tissue, not due to increased cell number " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001922 reduced male fertility "reduced ability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61340]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

Allelic Composition: Smarcad1tm1Gos/Smarcad1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0002161 abnormal fertility/fecundity "reduced ability or inability to produce live offspring" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Col14a1tm1Debi/Col14a1+
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003047 abnormal thoracic vertebrae morphology "malformation of any or all of the thirteen bony segments of the spine located anterior to the lumbar vertebrae and posterior to the cervical vertebrae" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0004174 abnormal spine curvature "deviation from the typical S-shape of the spine" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0004200 reduced fetal size "smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0004621 lumbar vertebral fusion "the union of one or more lumbar vertebrae into a single structure" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004678 split xiphoid process "the appearance of an abnormal division of the posterior tip of the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0008146 asymmetric rib-sternum attachment "loss of bilateral symmetry in rib attachments to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1+
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0008148 abnormal rib-sternum attachment "any anomaly in the in the normal joining of the ribs to the sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0009703 decreased birth body size "reduction in average body size at birth compared to controls" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0010103 small thoracic cage "reduced size of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Engtm1Hma/Engtm1Hma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011088 partial neonatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

 MP:0011090 partial perinatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Smarcad1tm1Gos/Smarcad1tm1Gos
Genetic Background: 129S2/SvPas-Smarcad1tm1Gos

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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