ENSMUSG00000030017


Mus musculus

Features
Gene ID: ENSMUSG00000030017
  
Biological name :Reg3g
  
Synonyms : O09049 / Reg3g / regenerating islet-derived 3 gamma
  
Possible biological names infered from orthology : Q06141 / Q6UW15 / REG3A / regenerating family member 3 alpha / regenerating family member 3 gamma
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: C3
Gene start: 78466269
Gene end: 78468872
  
Corresponding Affymetrix probe sets: 10545569 (MoGene1.0st)   1448872_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000032089
NCBI entrez gene - 19695     See in Manteia.
MGI - MGI:109406
RefSeq - NM_011260
RefSeq Peptide - NP_035390
swissprot - O09049
swissprot - Q545I1
Ensembl - ENSMUSG00000030017
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 REG3AENSG00000172016Homo sapiens
 REG3GENSG00000143954Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Reg3b / P35230 / Rerating islet-derived protein 3-beta Rerating islet-derived protein 3-beta 16.5 kDa form Rerating islet-derived protein 3-beta 15 kDa form / REG3G* / REG3A* / Q06141* / Q6...ENSMUSG0000007135671
Reg3a / O09037 / regenerating islet-derived 3 alpha / REG3G* / Q06141* / Q6UW15* / regenerating family member 3 alpha* / regenerating family member 3 gamma*ENSMUSG0000007951659
Reg3d / regenerating islet-derived 3 delta / REG3A* / REG3G* / Q6UW15* / Q06141* / regenerating family member 3 alpha* / regenerating family member 3 gamma*ENSMUSG0000006834150
Reg1 / P43137 / regenerating islet-derived 1 / REG1A* / REG1B* / P48304* / P05451* / regenerating family member 1 beta* / regenerating family member 1 alpha*ENSMUSG0000005965444
Reg2 / Q08731 / regenerating islet-derived 2 / REG1A* / REG1B* / P48304* / P05451* / regenerating family member 1 beta* / regenerating family member 1 alpha*ENSMUSG0000002314040
Reg4 / Q9D8G5 / Rerating islet-derived protein 4 / Q9BYZ8* / regenerating family member 4*ENSMUSG0000002787632


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IMP
 biological_processGO:0006953 acute-phase response IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0010838 positive regulation of keratinocyte proliferation IDA
 biological_processGO:0044278 cell wall disruption in other organism IDA
 biological_processGO:0045617 negative regulation of keratinocyte differentiation IDA
 biological_processGO:0050829 defense response to Gram-negative bacterium IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0051715 cytolysis in other organism IDA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 biological_processGO:0090303 positive regulation of wound healing IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0030141 secretory granule IDA
 cellular_componentGO:0044216 other organism cell IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042834 peptidoglycan binding ISO
 molecular_functionGO:0070492 oligosaccharide binding IDA


Pathways (from Reactome)
Pathway description
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000182 increased circulating LDL cholesterol level "greater than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0001556 increased circulating HDL cholesterol level "higher than average level of high density lipoprotein in the blood; this molecule transports cholesterol to the liver for excretion in bile" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47439]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Leprdb/Leprdb,Tg(SHBG)4-aGlha/0
Genetic Background: involves: C57BL/6 * C57BLKS/J * CBA

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

 MP:0003868 abnormal feces composition "increase or decrease in the amount of compunds normally found in the feces (fat, protein etc) or presence of material not normally seen in the feces" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

 MP:0008086 increased T-helper 1 cell number "greater number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [CL:0000545, ISBN:0781735149]
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Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

 MP:0010155 abnormal intestine physiology "any functional anomaly of the digestive tube passing from the stomach to the anus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

 MP:0010377 abnormal gut flora balance "anomaly in the ratio of microorganisms that live in the digestive tracts of animals, many of which perform symbiotic functions to the host" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Spo11tm1Nki/Spo11tm1Nki
Genetic Background: involves: 129P2/OlaHsd

 MP:0010850 increased effector memory CD8-positive, alpha-beta T cell number "increased number of CD8-positive, alpha beta memory T cells with the phenotype CCR7-negative, CD127-positive, CD45RO-positive, and CD25-negative" [CL:0000913, GO_REF:0000031, GOC:add, GOC:pam, PMID:20146720]
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Allelic Composition: Hsp90aa1tm1(KOMP)Wtsi/Hsp90aa1tm1(KOMP)Wtsi
Genetic Background: C57BL/6N-Hsp90aa1tm1(KOMP)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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