ENSMUSG00000030059


Mus musculus

Features
Gene ID: ENSMUSG00000030059
  
Biological name :Tmf1
  
Synonyms : B9EKI3 / TATA element modulatory factor / Tmf1
  
Possible biological names infered from orthology : P82094 / TATA element modulatory factor 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: D3
Gene start: 97152997
Gene end: 97179122
  
Corresponding Affymetrix probe sets: 10546586 (MoGene1.0st)   1442002_at (Mouse Genome 430 2.0 Array)   1442914_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000093325
Ensembl peptide - ENSMUSP00000120093
NCBI entrez gene - 232286     See in Manteia.
MGI - MGI:2684999
RefSeq - NM_001081111
RefSeq Peptide - NP_001074580
swissprot - D6RJK7
swissprot - B9EKI3
Ensembl - ENSMUSG00000030059
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tmf1ENSDARG00000057997Danio rerio
 TMF1ENSGALG00000013408Gallus gallus
 TMF1ENSG00000144747Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR022091  TATA element modulatory factor 1 TATA binding
 IPR022092  TATA element modulatory factor 1 DNA binding


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001675 acrosome assembly IMP
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007286 spermatid development IMP
 biological_processGO:0007289 spermatid nucleus differentiation IMP
 biological_processGO:0008584 male gonad development IMP
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0030317 flagellated sperm motility IMP
 biological_processGO:0032275 luteinizing hormone secretion IMP
 biological_processGO:0033327 Leydig cell differentiation IMP
 biological_processGO:0042742 defense response to bacterium IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IDA
 biological_processGO:0071407 cellular response to organic cyclic compound IMP
 biological_processGO:2000845 positive regulation of testosterone secretion IMP
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Retrograde transport at the Trans-Golgi-Network


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001919 abnormal reproductive system physiology "anomaly in the function of the organs associated with producing offspring " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002160 abnormal reproductive system morphology "structural or developmental anomaly of any of the tissues involved in the reproductive system" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002675 asthenozoospermia "loss or reduction of the mobility of the spermatozoa, frequently associated with infertility" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002686 globozoospermia "malformation of the acrosome resulting in a round sperm head" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:57312]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008839 absent acrosome "mature spermatozoa lack the cap-like structure at the anterior end of the sperm head that produces enzymes needed for egg penetration" [MESH:A05.360.490.890.820.100, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009831 abnormal sperm midpiece morphology "any structural abnormality of the highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece" [PMID:14581499]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0009832 abnormal sperm mitochondrial sheath morphology "any structural anomaly or impairment of the tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum" [PMID:14581499]
Show

Allelic Composition: Gsk3btm1.1Ypc/Gsk3btm1.1Ypc,Tg(Pitx2-cre)1Ych/0
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000030059 Tmf1 / B9EKI3 / TATA element modulatory factor / P82094* / TATA element modulatory factor 1*  / complex






 

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