ENSMUSG00000030491


Mus musculus

Features
Gene ID: ENSMUSG00000030491
  
Biological name :Tdrd12
  
Synonyms : Putative ATP-dependent RNA helicase TDRD12 / Q9CWU0 / Tdrd12
  
Possible biological names infered from orthology : Q587J7 / tudor domain containing 12
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: B2
Gene start: 35469098
Gene end: 35537745
  
Corresponding Affymetrix probe sets: 10562468 (MoGene1.0st)   1453219_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145609
Ensembl peptide - ENSMUSP00000032701
Ensembl peptide - ENSMUSP00000145652
Ensembl peptide - ENSMUSP00000118671
Ensembl peptide - ENSMUSP00000141796
Ensembl peptide - ENSMUSP00000140328
NCBI entrez gene - 71981     See in Manteia.
MGI - MGI:1919231
RefSeq - XM_017312318
RefSeq - XM_011250699
RefSeq - XM_011250704
RefSeq - XM_011250707
RefSeq - XM_017312314
RefSeq - XM_017312315
RefSeq - XM_017312316
RefSeq - XM_017312317
RefSeq - NM_028034
RefSeq - XM_011250698
RefSeq Peptide - NP_082310
swissprot - A0A0U1RNL0
swissprot - A0A0A6YX17
swissprot - A0A0U1RNP6
swissprot - D3YZI6
swissprot - Q9CWU0
swissprot - A0A087WQS9
Ensembl - ENSMUSG00000030491
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdrd12ENSDARG00000075217Danio rerio
 ENSGALG00000004704Gallus gallus
 Q587J7ENSG00000173809Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002999  Tudor domain
 IPR007052  CS domain
 IPR008978  HSP20-like chaperone
 IPR011545  DEAD/DEAH box helicase domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035437  SNase-like, OB-fold superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IMP
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:1903955 positive regulation of protein targeting to mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:1990923 PET complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Tdrd12tm1Yam/Tdrd12tm1Yam
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tdrd12tm1Yam/Tdrd12tm1Yam
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tdrd12tm1Yam/Tdrd12tm1Yam
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002216 abnormal seminiferous tubule morphology "malformation of the tubules in the testes where spermatogenesis occurs" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm2(CAG-Dsred2/EGFP)Luo/Gt(ROSA)26Sortm1(Notch3*)Sfr,Notch3tm1.1(cre/ERT2)Sat/Notch3+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Tdrd12tm1Yam/Tdrd12tm1Yam
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004543 abnormal sperm physiology "anomaly in the normal function of spermatozoa" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tdrd12tm1Yam/Tdrd12tm1Yam
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0004929 decreased epididymis weight "reduction in the average weight of the elongated structure connected to the posterior surface of the testis that transports, stores, and matures spermatozoa between testis and vas deferens" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tdrd12tm1Yam/Tdrd12tm1Yam
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

Allelic Composition: Tdrd12tm1Yam/Tdrd12tm1Yam
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Lhx4tm1Ssp/Lhx4tm1Ssp
Genetic Background: involves: 129S2/SvPas * CF1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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