ENSMUSG00000030533


Mus musculus

Features
Gene ID: ENSMUSG00000030533
  
Biological name :Unc45a
  
Synonyms : Q99KD5 / Unc45a / unc-45 myosin chaperone A
  
Possible biological names infered from orthology : Q9H3U1
  
Species: Mus musculus
  
Chr. number: 7
Strand: -1
Band: D2
Gene start: 80325292
Gene end: 80341005
  
Corresponding Affymetrix probe sets: 10564888 (MoGene1.0st)   1415866_at (Mouse Genome 430 2.0 Array)   1455912_x_at (Mouse Genome 430 2.0 Array)   1458824_at (Mouse Genome 430 2.0 Array)   1459867_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000102991
Ensembl peptide - ENSMUSP00000145577
Ensembl peptide - ENSMUSP00000123399
Ensembl peptide - ENSMUSP00000119665
Ensembl peptide - ENSMUSP00000114428
Ensembl peptide - ENSMUSP00000032748
NCBI entrez gene - 101869     See in Manteia.
MGI - MGI:2142246
RefSeq - XM_006540542
RefSeq - XM_017321917
RefSeq - XM_011250775
RefSeq - XM_011250774
RefSeq - NM_133952
RefSeq Peptide - NP_598713
swissprot - Q99KD5
swissprot - D6RIN1
swissprot - A0A0U1RNI4
swissprot - D3YVI2
swissprot - D3YZN8
Ensembl - ENSMUSG00000030533
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 unc45aENSDARG00000103643Danio rerio
 UNC45AENSGALG00000029714Gallus gallus
 Q9H3U1ENSG00000140553Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CGY6 / Unc45b / unc-45 myosin chaperone B / Q8IWX7*ENSMUSG0000001884555
Rpap3 / Q9D706 / RNA polymerase II-associated protein 3 / Q9H6T3*ENSMUSG0000002246611
Q9CZW5 / Tomm70a / Mitochondrial import receptor subunit TOM70 / O94826* / TOMM70* / translocase of outer mitochondrial membrane 70*ENSMUSG000000227529
Spag1 / Q80ZX8 / Sperm-associated antigen 1 / Q07617*ENSMUSG000000376179
Ttc1 / Q91Z38 / tetratricopeptide repeat domain 1 / Q99614*ENSMUSG000000412786
Q9CYG7 / Tomm34 / Mitochondrial import receptor subunit TOM34 / Q15785* / translocase of outer mitochondrial membrane 34*ENSMUSG000000183226


Protein motifs (from Interpro)
Interpro ID Name
 IPR011989  Armadillo-like helical
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR013026  Tetratricopeptide repeat-containing domain
 IPR016024  Armadillo-type fold
 IPR019734  Tetratricopeptide repeat
 IPR024660  UNC-45/Cro1/She4, central domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0061077 chaperone-mediated protein folding IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0051879 Hsp90 protein binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Ube2ctm1.1(KOMP)Wtsi/Ube2c+
Genetic Background: C57BL/6N-Ube2ctm1.1(KOMP)Wtsi/J

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ube2ctm1.1(KOMP)Wtsi/Ube2c+
Genetic Background: C57BL/6N-Ube2ctm1.1(KOMP)Wtsi/J

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ube2ctm1.1(KOMP)Wtsi/Ube2c+
Genetic Background: C57BL/6N-Ube2ctm1.1(KOMP)Wtsi/J

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ube2ctm1.1(KOMP)Wtsi/Ube2c+
Genetic Background: C57BL/6N-Ube2ctm1.1(KOMP)Wtsi/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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