ENSMUSG00000030779


Mus musculus

Features
Gene ID: ENSMUSG00000030779
  
Biological name :Rbbp6
  
Synonyms : E3 ubiquitin-protein ligase RBBP6 / P97868 / Rbbp6
  
Possible biological names infered from orthology : Q7Z6E9 / RB binding protein 6, ubiquitin ligase
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F2
Gene start: 122965686
Gene end: 123002557
  
Corresponding Affymetrix probe sets: 10557206 (MoGene1.0st)   10557211 (MoGene1.0st)   10557213 (MoGene1.0st)   1425114_at (Mouse Genome 430 2.0 Array)   1425115_at (Mouse Genome 430 2.0 Array)   1426487_a_at (Mouse Genome 430 2.0 Array)   1453611_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000071519
Ensembl peptide - ENSMUSP00000145759
Ensembl peptide - ENSMUSP00000115530
Ensembl peptide - ENSMUSP00000095670
Ensembl peptide - ENSMUSP00000049528
NCBI entrez gene - 19647     See in Manteia.
MGI - MGI:894835
RefSeq - XM_006507470
RefSeq - NM_011247
RefSeq - NM_175023
RefSeq Peptide - NP_035377
RefSeq Peptide - NP_778188
swissprot - P97868
swissprot - D3YZU8
swissprot - A0A0R4J165
swissprot - A0A0U1RNZ1
Ensembl - ENSMUSG00000030779
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rbbp6ENSDARG00000037919Danio rerio
 RBBP6ENSGALG00000006043Gallus gallus
 RBBP6ENSG00000122257Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001841  Zinc finger, RING-type
 IPR001878  Zinc finger, CCHC-type
 IPR003613  U box domain
 IPR013083  Zinc finger, RING/FYVE/PHD-type
 IPR014891  DWNN domain
 IPR025829  Zinc knuckle CX2CX3GHX4C
 IPR033489  E3 ubiquitin-protein ligase RBBP6
 IPR036875  Zinc finger, CCHC-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006275 regulation of DNA replication ISS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISO
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0035264 multicellular organism growth IMP
 biological_processGO:0048568 embryonic organ development IGI
 biological_processGO:0061053 somite development IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISO
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity ISS


Pathways (from Reactome)
Pathway description
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk,Gas1tm2Fan/Gas1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Cdontm2Rsk/Cdontm2Rsk,Gas1tm2Fan/Gas1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0006042 increased apoptosis "greater than normal programmed cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk,Gas1tm2Fan/Gas1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Cdontm2Rsk/Cdontm2Rsk,Gas1tm2Fan/Gas1+
Genetic Background: involves: 129 * C57BL/6J

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Rbbp6tm1Xya/Rbbp6tm1Xya,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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