ENSMUSG00000030795


Mus musculus

Features
Gene ID: ENSMUSG00000030795
  
Biological name :Fus
  
Synonyms : Fus / P56959 / RNA-binding protein FUS
  
Possible biological names infered from orthology : FUS RNA binding protein / P35637
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 127967457
Gene end: 127985701
  
Corresponding Affymetrix probe sets: 10557843 (MoGene1.0st)   10557853 (MoGene1.0st)   1442354_at (Mouse Genome 430 2.0 Array)   1451285_at (Mouse Genome 430 2.0 Array)   1451286_s_at (Mouse Genome 430 2.0 Array)   1455831_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134447
Ensembl peptide - ENSMUSP00000076801
Ensembl peptide - ENSMUSP00000078054
Ensembl peptide - ENSMUSP00000101858
Ensembl peptide - ENSMUSP00000112721
Ensembl peptide - ENSMUSP00000133820
NCBI entrez gene - 233908     See in Manteia.
MGI - MGI:1353633
RefSeq - XM_017322218
RefSeq - NM_139149
RefSeq - XM_006507759
RefSeq - XM_006507760
RefSeq Peptide - NP_631888
RefSeq Peptide - NP_001334578
swissprot - Q564D0
swissprot - Q8BNR3
swissprot - Q8CFQ9
swissprot - Q91VQ2
swissprot - G3UZD2
swissprot - G3UXT7
swissprot - P56959
Ensembl - ENSMUSG00000030795
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 fusENSDARG00000037968Danio rerio
 FUSENSG00000089280Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ewsr1 / Q61545 / RNA-binding protein EWS / Q01844* / EWS RNA binding protein 1*ENSMUSG0000000907956
Taf15 / TATA-box binding protein associated factor 15 / Q92804*ENSMUSG0000002068053


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR001876  Zinc finger, RanBP2-type
 IPR034459  RNA-binding protein FUS
 IPR034870  TAF15/EWS/TLS family
 IPR035979  RNA-binding domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043197 dendritic spine IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0044327 dendritic spine head IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0030331 estrogen receptor binding IEA
 molecular_functionGO:0031489 myosin V binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0046965 retinoid X receptor binding IEA
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA


Pathways (from Reactome)
Pathway description
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000706 small thymus "reduced size of the thymus" [J:36561, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31167]
Show

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000938 motor neuron degeneration "retrogressive impairment of function or destruction of the cells that innervate an effector (muscle or glandular) tissue" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fustm1Emcf/Fus+
Genetic Background: involves: C3H * C57BL/6J * C57BL/6N

 MP:0000939 reduced motor neuron number "fewer than normal numbers of cells that innervate an effector (muscle or glandular) tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Fustm1Emcf/Fus+
Genetic Background: involves: C3H * C57BL/6J * C57BL/6N

 MP:0001053 abnormal neuromuscular synapse "malformed or absent membrane to membrane contact of a motor axon and a muscle myofiber resulting in aberrant transmission of nerve impulses" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159, J:47439]
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Allelic Composition: Fustm1a(EUCOMM)Wtsi/Fustm1c(EUCOMM)Wtsi,Mapttm3.1(FUS)Neas/Mapt+,Ndor1Tg(UBC-cre/ERT2)1Ejb/0
Genetic Background: involves: 129 * C3H * C57BL/6 * C57BL/6N

Allelic Composition: Fustm1Emcf/Fus+
Genetic Background: involves: C3H * C57BL/6J * C57BL/6N

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001406 abnormal gait "unusual or distinctive way of walking" [J:65038]
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Allelic Composition: Fustm1Emcf/Fus+
Genetic Background: involves: C3H * C57BL/6J * C57BL/6N

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001524 impaired limb coordination "reduced ability to organize limb movements to execute complex maneuvers, such as walking" [J:64962, MGI:CLS, J:17123]
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Allelic Composition: Fustm1Emcf/Fus+
Genetic Background: involves: C3H * C57BL/6J * C57BL/6N

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Ftsj1tm1b(EUCOMM)Wtsi/Ftsj1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ftsj1tm1b(EUCOMM)Wtsi/Bay

Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001923 reduced female fertility "reduced ability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Fustm1Emcf/Fus+
Genetic Background: involves: C3H * C57BL/6J * C57BL/6N

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mapttm3.1(FUS)Neas/Mapttm3.1(FUS)Neas
Genetic Background: B6J.129P2(129S)-Mapttm3.1(FUS)Neas

 MP:0002223 lymphoid hypoplasia "decreased cell number in lymphatic tissue" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Ftsj1tm1b(EUCOMM)Wtsi/Ftsj1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ftsj1tm1b(EUCOMM)Wtsi/Bay

 MP:0003702 abnormal chromosome morphology "anomalies in the structure of the compact, intertwined molecules of DNA found in the nucleus which carry genetic information " [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004024 aneuploidy "chromosome count is not an exact multiple of the haploid number " [llw2:Linda Washburn , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004028 chromosome breakage "chromosome instability in the from of increased frequency of spontaneous breakage with or without rearrangements" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tfamtm1Lrsn/Tfamtm1Lrsn,Tg(Camk2a-cre)1Lfr/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
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Allelic Composition: Ftsj1tm1b(EUCOMM)Wtsi/Ftsj1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ftsj1tm1b(EUCOMM)Wtsi/Bay

 MP:0009141 increased prepulse inhibition "increase in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ftsj1tm1b(EUCOMM)Wtsi/Ftsj1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ftsj1tm1b(EUCOMM)Wtsi/Bay

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cd80tm1Lbgn/Cd80tm1Lbgn
Genetic Background: C3.Cg-Cd80tm1Lbgn

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Juntm1Wag/Juntm1Wag,Tg(Junb)1598Angl/0
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Gab1tm1Wbm/Gab1tm1Wbm
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Fustm1d(EUCOMM)Wtsi/Fustm1d(EUCOMM)Wtsi
Genetic Background: involves: 129S4/SvJae * C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Fustm1.1(KOMP)Vlcg/Fustm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Fustm1.1(KOMP)Vlcg/Ucd

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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