ENSMUSG00000009079


Mus musculus

Features
Gene ID: ENSMUSG00000009079
  
Biological name :Ewsr1
  
Synonyms : Ewsr1 / Q61545 / RNA-binding protein EWS
  
Possible biological names infered from orthology : EWS RNA binding protein 1 / Q01844
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 5069689
Gene end: 5099266
  
Corresponding Affymetrix probe sets: 10383943 (MoGene1.0st)   1417238_at (Mouse Genome 430 2.0 Array)   1436884_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000091057
Ensembl peptide - ENSMUSP00000073034
Ensembl peptide - ENSMUSP00000078867
Ensembl peptide - ENSMUSP00000066827
Ensembl peptide - ENSMUSP00000099994
NCBI entrez gene - 14030     See in Manteia.
MGI - MGI:99960
RefSeq - XM_017314255
RefSeq - NM_001283061
RefSeq - NM_001283062
RefSeq - NM_001283063
RefSeq - NM_007968
RefSeq - XM_006514508
RefSeq - XM_006514509
RefSeq - XM_006514510
RefSeq - XM_006514511
RefSeq - XM_006514512
RefSeq Peptide - NP_001269992
RefSeq Peptide - NP_031994
RefSeq Peptide - NP_001269990
RefSeq Peptide - NP_001269991
swissprot - Q5SUT0
swissprot - Q5SUS9
swissprot - Q61545
swissprot - Q8BQU4
swissprot - Q5SUS8
Ensembl - ENSMUSG00000009079
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ewsr1aENSDARG00000020258Danio rerio
 ewsr1bENSDARG00000117011Danio rerio
 ewsr1bENSDARG00000020465Danio rerio
 EWSR1ENSGALG00000008149Gallus gallus
 EWSR1ENSG00000182944Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Fus / P56959 / RNA-binding protein FUS / P35637* / FUS RNA binding protein*ENSMUSG0000003079544
Taf15 / TATA-box binding protein associated factor 15 / Q92804*ENSMUSG0000002068037


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR001876  Zinc finger, RanBP2-type
 IPR033109  RNA-binding protein EWS
 IPR034869  EWS, RNA recognition motif
 IPR034870  TAF15/EWS/TLS family
 IPR035979  RNA-binding domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000160 kyphosis "forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001126 abnormal ovary morphology "malformed female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001134 absent corpora lutea "missing yellow endocrine body formed in the ovary after follicle rupture" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001146 abnormal testis morphology "anomalous structure of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001399 hyperactivity "general restlessness or excessive movement; more frequent movement from one place to another" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409, J:57125]
Show

Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0001658 increased mortality induced by gamma-irradiation "greater sensitivity to doses of ionizing radiation" [J:51834]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002024 T cell derived lymphoma "group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Cadpstm1Bros/Cadps+
Genetic Background: Not Specified

 MP:0002026 leukemia "progressive proliferation of abnormal leukocytes in hematopoietic tissues, organs and blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18542]
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Allelic Composition: Cadpstm1Bros/Cadps+
Genetic Background: Not Specified

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0002192 hydrops fetalis "an abnormal accumulation of serous fluid in fetal tissues" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

Allelic Composition: Ewsr1tm1b(EUCOMM)Wtsi/Ewsr1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ewsr1tm1b(EUCOMM)Wtsi/Tcp

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002764 short tibia " reduced length of the medial and larger bone of the lower leg" [J:12736, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002968 increased circulating alkaline phosphatase level "elevated activity of this enzyme, which hydrolyzes orthophosphoric monoesters, found in the blood" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0003111 abnormal nucleus morphology "abnormalities in the nucleus and/or its surrounding membrane" [J:91473, smb:Susan M. Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0004153 increased renal tubule apoptosis "increase in the number of renal tubule cells undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ewsr1tm1(ERG)Thr/Ewsr1+,Rag1tm1(cre)Thr/Rag1+
Genetic Background: involves: 129S/SvEv

 MP:0005092 decreased double-positive T cell count "less than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005169 abnormal male meiosis "malfunction in the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008008 early cellular replicative senescence "increase in the progression of the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008209 decreased pre-B cell number "reduced number of the cells in the B lymphocyte lineage that have undergone VDJ rearrangement of the immunoglobulin heavy chain and are in the process of V-J rearrangement of the light chain: these cells express mu heavy chain on the cell surface" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008215 decreased immature B cell number "reduced number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008843 absent subcutaneous adipose tissue "absence of adipose tissue beneath the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Ewsr1tm1b(EUCOMM)Wtsi/Ewsr1tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Ewsr1tm1b(EUCOMM)Wtsi/Tcp

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Lims2tm1Ref/Lims2tm1Ref
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Epas1tm1b(EUCOMM)Hmgu/Epas1+
Genetic Background: C57BL/6N-Epas1tm1b(EUCOMM)Hmgu/H

 MP:0013501 increased fibroblast apoptosis "increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]
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Allelic Composition: Klc1tm1Gsn/Klc1tm1Gsn
Genetic Background: B6.129-Klc1tm1Gsn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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