ENSG00000182944


Homo sapiens

Features
Gene ID: ENSG00000182944
  
Biological name :EWSR1
  
Synonyms : EWSR1 / EWS RNA binding protein 1 / Q01844
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q12.2
Gene start: 29268009
Gene end: 29300525
  
Corresponding Affymetrix probe sets: 209214_s_at (Human Genome U133 Plus 2.0 Array)   210011_s_at (Human Genome U133 Plus 2.0 Array)   210012_s_at (Human Genome U133 Plus 2.0 Array)   229966_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000385726
Ensembl peptide - ENSP00000381031
Ensembl peptide - ENSP00000393637
Ensembl peptide - ENSP00000486709
Ensembl peptide - ENSP00000416171
Ensembl peptide - ENSP00000412670
Ensembl peptide - ENSP00000406824
Ensembl peptide - ENSP00000405947
Ensembl peptide - ENSP00000400142
Ensembl peptide - ENSP00000395200
Ensembl peptide - ENSP00000327456
Ensembl peptide - ENSP00000330516
Ensembl peptide - ENSP00000330896
Ensembl peptide - ENSP00000331699
Ensembl peptide - ENSP00000353204
NCBI entrez gene - 2130     See in Manteia.
OMIM - 133450
RefSeq - XM_017028666
RefSeq - XM_017028650
RefSeq - XM_017028651
RefSeq - XM_017028652
RefSeq - XM_017028653
RefSeq - XM_017028654
RefSeq - XM_017028655
RefSeq - XM_017028656
RefSeq - XM_017028657
RefSeq - XM_017028658
RefSeq - XM_017028659
RefSeq - XM_017028660
RefSeq - XM_017028661
RefSeq - XM_017028662
RefSeq - XM_017028663
RefSeq - XM_017028664
RefSeq - XM_017028665
RefSeq - NM_001163285
RefSeq - NM_001163286
RefSeq - NM_001163287
RefSeq - NM_005243
RefSeq - NM_013986
RefSeq - XM_005261389
RefSeq - XM_005261390
RefSeq - XM_011529995
RefSeq - XM_011529996
RefSeq - XM_011529997
RefSeq - XM_011529998
RefSeq - XM_011529999
RefSeq - XM_011530000
RefSeq - XM_011530001
RefSeq - XM_011530002
RefSeq - XM_017028644
RefSeq - XM_017028645
RefSeq - XM_017028646
RefSeq - XM_017028647
RefSeq - XM_017028648
RefSeq - XM_017028649
RefSeq Peptide - NP_053733
RefSeq Peptide - NP_001156759
RefSeq Peptide - NP_005234
RefSeq Peptide - NP_001156757
RefSeq Peptide - NP_001156758
swissprot - B0QYJ4
swissprot - B0QYJ3
swissprot - F8WC90
swissprot - C9JGE3
swissprot - Q01844
swissprot - A0A0D9SFL3
swissprot - H7BY36
swissprot - B0QYK0
swissprot - B0QYJ7
swissprot - B0QYJ6
swissprot - B0QYJ5
Ensembl - ENSG00000182944
  
Related genetic diseases (OMIM): 612219 - Ewing sarcoma, 612219
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ewsr1aENSDARG00000020258Danio rerio
 ewsr1bENSDARG00000117011Danio rerio
 ewsr1bENSDARG00000020465Danio rerio
 EWSR1ENSGALG00000008149Gallus gallus
 Ewsr1ENSMUSG00000009079Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FUS / P35637 / FUS RNA binding proteinENSG0000008928044
TAF15 / Q92804 / TATA-box binding protein associated factor 15ENSG0000027064736


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR001876  Zinc finger, RanBP2-type
 IPR033109  RNA-binding protein EWS
 IPR034869  EWS, RNA recognition motif
 IPR034870  TAF15/EWS/TLS family
 IPR035979  RNA-binding domain superfamily
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005516 calmodulin binding IEA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0001428 Somatic mutation 
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 HP:0001541 Ascites 
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 HP:0001903 Anemia 
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 HP:0002017 Nausea and vomiting 
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 HP:0002027 Abdominal pain 
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 HP:0002240 Hepatomegaly "An abnormal enlargment of the liver." [HPO:curators]
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 HP:0002585 Abnormality of the peritoneum 
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 HP:0002595 Ileus "Acute obstruction of the intestines preventing passage of the contents of the intestines." [HPO:sdoelken]
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 HP:0002894 Pancreatic cancer 
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 HP:0003270 Abdominal distention "Enlargement or distention of the abdomen, which can be a secondary feature associated with a number of conditions such as bowel obstruction." [HPO:curators]
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 HP:0004326 Cachexia 
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 HP:0010788 Testicular neoplasia 
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 HP:0012254 Ewing s sarcoma "A malignant tumor of the bone which always arises in the medullary tissue, occurring more often in cylindrical bones." [HPO:probinson, pmid:17272319]
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 HP:0100006 Neoplasia of the central nervous system 
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 HP:0100242 Sarcoma "The presence of a `sarcoma` (MPATH:551)." [HPO:sdoelken]
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 HP:0100526 Neoplasia of the lungs 
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 HP:0100615 Ovarian neoplasm "The presence of a `neoplasm` (MPATH:218) the `ovary` (FMA:7209)." [HPO:probinson]
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 HP:0100721 Mediastinal lymphadenopathy 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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